Protein detail
FFAR4
Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)
Protein symbol FFAR4 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)
Protein Function
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Transporters
- FDA approved drug targets:Biotech drugs
Transmembrane
46..66; Helical; Name=1; 78..98; Helical; Name=2; 113..133; Helical; Name=3; 157..177; Helical; Name=4; 205..225; Helical; Name=5; 269..289; Helical; Name=6; 296..316; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificEpicardial cells
Function & Pathway
Protein Function
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Transporters
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-444209 free fatty acid receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-400508 incretin synthesis secretion and inactivation
- R-hsa-2980736 peptide hormone metabolism
- R-hsa-372790 signaling by gpcr
- R-hsa-381771 synthesis secretion and inactivation of glucagon like peptide 1 glp 1
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FFAR4 | GRK1 | Q15835 | S | 366 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | GRK1 | Q15835 | T | 363 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | GRK1 | Q15835 | S | 373 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | PRKCA | P17252 | S | 366 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | PRKCA | P17252 | T | 363 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | PRKCA | P17252 | S | 373 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP |
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_lipid | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_lipid_free_fatty_acid | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FFAR4 | Q5NUL3 | GNAL | P38405 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| KPCA | P17252 | FFAR4 | Q5NUL3 | Yes | No | No | MIMPiPTMnetPhosphoSitePhosphoSite_MIMP | PhosphoSite:24817122PhosphoSite:24412271 |
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Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Western BlottingMass SpectrometryImmunoelectron Microscopy | 1 | 37620511 |
Sequence, Structure & Domains
Sequences
Length
361
Mass
40,494
Sequence
MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q5NUL3-2; Sequence=Displayed; Name=1; IsoId=Q5NUL3-1; Sequence=VSP_060543
Alternative Sequence
232; Q -> QTSEHLLDARAVVTHSE (in isoform 1)
3D Structural Models
Turn
37..39; 143..146; 185..187; 321..325
Helix
43..69; 78..90; 92..100; 110..141; 153..168; 169..171; 172..175; 202..243; 249..291; 300..320
Beta Strand
73..76; 101..103; 176..182; 191..196
3D Structure
Electron microscopy (12)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.