Protein detail
FFAR4
Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)
Protein symbol FFAR4 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)
Protein Function
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Transporters
- FDA approved drug targets:Biotech drugs
Transmembrane
46..66; Helical; Name=1; 78..98; Helical; Name=2; 113..133; Helical; Name=3; 157..177; Helical; Name=4; 205..225; Helical; Name=5; 269..289; Helical; Name=6; 296..316; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificEpicardial cells
Function & Pathway
Protein Function
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Transporters
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-444209 free fatty acid receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-400508 incretin synthesis secretion and inactivation
- R-hsa-2980736 peptide hormone metabolism
- R-hsa-372790 signaling by gpcr
- R-hsa-381771 synthesis secretion and inactivation of glucagon like peptide 1 glp 1
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FFAR4 | GRK1 | Q15835 | S | 366 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | GRK1 | Q15835 | T | 363 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | GRK1 | Q15835 | S | 373 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | PRKCA | P17252 | S | 366 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | PRKCA | P17252 | T | 363 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP | |
| FFAR4 | PRKCA | P17252 | S | 373 | phosphorylation | MIMPPhosphoSitePhosphoSite_MIMP |
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FFAR4 | Q5NUL3 | GNAS1 | Q5JWF2 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | GNAS3 | O95467 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | ALEX | P84996 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | GNAS2 | P63092 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | GNAQ | P50148 | Yes | Yes | No | HINTSIGNOR | HINT:37286793SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | GNA14 | O95837 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| FFAR4 | Q5NUL3 | GNAI1 | P63096 | Yes | Yes | No | HINTSIGNOR | HINT:36862765SIGNOR:31160049 |
Page 1 of 2Next
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Western BlottingMass SpectrometryImmunoelectron Microscopy | 1 | 37620511 |
Sequence, Structure & Domains
Sequences
Length
361
Mass
40,494
Sequence
MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q5NUL3-2; Sequence=Displayed; Name=1; IsoId=Q5NUL3-1; Sequence=VSP_060543
Alternative Sequence
232; Q -> QTSEHLLDARAVVTHSE (in isoform 1)
3D Structural Models
Turn
37..39; 143..146; 185..187; 321..325
Helix
43..69; 78..90; 92..100; 110..141; 153..168; 169..171; 172..175; 202..243; 249..291; 300..320
Beta Strand
73..76; 101..103; 176..182; 191..196
3D Structure
Electron microscopy (12)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.