Protein detail
CL12A
C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)
Protein symbol CL12A | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 1 | Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)
Protein Class
CD markersPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Transporter channels and pores
- CD markers
- Predicted intracellular proteins
Transmembrane
44..64; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD371CLL-1DCAL-2MICL
Gene Description
C-type lectin domain family 12 member A
Chromosome
12
Position
9951316-9995694
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
39 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| scavenger | receptor | Almen2009 | No | Yes | No | Yes | No |
| other_receptor_family | receptor | HPMR | No | Yes | No | Yes | No |
| scavenger | receptor | HPMR | No | Yes | No | Yes | No |
| c_lectinn_containing_scavenger_scavenger | receptor | HPMR | No | Yes | No | Yes | No |
| class_e | receptor | Surfaceome | No | Yes | No | Yes | No |
| scar | receptor | Surfaceome | No | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryWestern blottingR SequencingFlow cytometryELISA | 12 | 392904593887173034817906327954143873186825471207300713182210607137686366383215353849095840098346 |
Sequence, Structure & Domains
Sequences
Length
265
Mass
30,762
Sequence
MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVLASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRELYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFIKSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHCTYKKRMICEKMANPVQLGSTYFREA
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=2; Synonyms=Alpha; IsoId=Q5QGZ9-2; Sequence=Displayed; Name=1; IsoId=Q5QGZ9-1; Sequence=VSP_039854; Name=3; Synonyms=Gamma; IsoId=Q5QGZ9-3; Sequence=VSP_030031, VSP_030032; Name=4; Synonyms=Beta; IsoId=Q5QGZ9-4; Sequence=VSP_030030; Name=5; IsoId=Q5QGZ9-5; Sequence=VSP_030033
Alternative Sequence
1; M -> MWIDFFTYSSM (in isoform 1); 31..64; APPAPSHVWRPAALFLTLLCLLLLIGLGVLASMF -> V (in isoform 4); 64..81; FHVTLKIEMKKMNKLQNI -> CMYCPCFGQEEVSRISNI (in isoform 3); 82..265; Missing (in isoform 3); 214..265; Missing (in isoform 5)
3D Structural Models
Helix
101..124; 154..163; 174..183; 205..207; 212..214; 222..224
Beta Strand
138..140; 143..147; 186..190; 196..198; 225..231; 234..239; 244..251
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Motif
5..10; ITIM motif
Domain (CC)
The immunoreceptor tyrosine-based inhibitor motif (ITIM) is involved in modulation of cellular responses (PubMed:14739280). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing protein phosphatases, such as PTPN6 and PTPN11 (PubMed:14739280).
Domain (FT)
140..249; C-type lectin