Protein detail

ZNG1E

Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5)

Entry name ZNG1E	UniProt ID Q5RIA9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc-regulated GTPase metalloprotein activator 1E (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 5) (COBW domain-containing protein 5)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000147996

Entrez Gene Symbol

ZNG1E

Gene Synonym

CBWD5

Gene Description

Zn regulated GTPase metalloprotein activator 1E

Chromosome

Position

65668805-65734041

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryR Sequencing	12	39290459 39443544 37702715 38731868 34341426 25471207 30071318 32927759 36635400 37686366 34131392 40091455

Sequence, Structure & Domains11

Sequences

Length

395

Mass

44,068

Sequence

MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVTSMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5RIA9-1; Sequence=Displayed; Name=2; IsoId=Q5RIA9-2; Sequence=VSP_033808; Name=3; IsoId=Q5RIA9-3; Sequence=VSP_040475, VSP_040476

Alternative Sequence

1..291; Missing (in isoform 2); 192..220; Missing (in isoform 3); 236..254; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

8..20; Acidic residues

Motif

17..24; psi-PxLVp motif; 107..110; CXCC motif

Domain (FT)

274..377; CobW C-terminal

Region

1..22; Disordered

Protein Families (2)

SIMIBI class G3E GTPase family
ZNG1 subfamily

Sequence Similarities

Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

Clinical Relevance1

Antibody (2)

HPA042759 HPA042813

Supporting Publications1

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available