Protein detail
ODR4
Protein odr-4 homolog (hODR-4) (LAG1-interacting protein) (Transactivated by transforming growth factor beta protein 1)
Entry name ODR4 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 7 | Transmembrane count 2 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Protein odr-4 homolog (hODR-4) (LAG1-interacting protein) (Transactivated by transforming growth factor beta protein 1)
Protein Class
Predicted membrane proteins
Transmembrane
82..102; Helical; 432..452; Helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
C1orf27FLJ20505odr-4TTG1
Gene Description
Odr-4 GPCR localization factor homolog
Chromosome
1
Position
186375838-186421378
Supporting publications (n)
7
EVMP confidence score
0.63
Fluorescence & Localization3
Tissue SpecificintestineCell SpecificColonocytes
Function & Pathway3
Cellular Component
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence13
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains7
Sequences
Length
454
Mass
51,103
Sequence
MGRTYIVEETVGQYLSNINLQGKAFVSGLLIGQCSSQKDYVILATRTPPKEEQSENLKHPKAKLDNLDEEWATEHACQVSRMLPGGLLVLGVFIITTLELANDFQNALRRLMFAVEKSINRKRLWNFTEEEVSERVTLHICASTKKIFCRTYDIHDPKSSARPADWKYQSGLSSSWLSLECTVHINIHIPLSATSVSYTLEKNTKNGLTRWAKEIENGVYLINGQVKDEDCDLLEGQKKSSRGNTQATSHSFDVRVLTQLLLNSDHRSTATVQICSGSVNLKGAVKCRAYIHSSKPKVKDAVQAVKRDILNTVADRCEMLFEDLLLNEIPEKKDSEKEFHVLPYRVFVPLPGSTVMLCDYKFDDESAEEIRDHFMEMLDHTIQIEDLEIAEETNTACMSSSMNSQASLDNTDDEQPKQPIKTTMLLKIQQNIGVIAAFTVAVLAAGISFHYFSD
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5SWX8-1; Sequence=Displayed; Name=2; IsoId=Q5SWX8-2; Sequence=VSP_028098; Name=3; IsoId=Q5SWX8-3; Sequence=VSP_028099, VSP_028100; Name=4; IsoId=Q5SWX8-4; Sequence=VSP_044478
Alternative Sequence
79..110; Missing (in isoform 4); 238..260; Missing (in isoform 2); 334..335; DS -> RF (in isoform 3); 336..454; Missing (in isoform 3)
Domain & Motif Annotations
Protein Families
ODR-4 family
Sequence Similarities
Belongs to the ODR-4 family.
Supporting Publications7
| PMID | Title | Abstract |
|---|---|---|
| 19190083 | Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. | Biochemical characterization further revealed typical surface, cytoskeletal, and cytoplasmic proteins characteristic of exosomes, including the multivesicular and late endosomal membrane markers Tsg101 and CD63. |
| 37423660 | Functionalized carbon nanotube field-effect transistor biosensor for highly sensitive detection of exosomal protein. | Here, we describe a polymer-sorted high-purity semiconducting carbon nanotubes (CNTs) films-based field-effect transistor (FET) biosensor for ultrasensitive and label-free detection of MUC1, a transmembrane protein highly expressed in breast cancer exosomes. |
| 37445655 | Lyophilization Based Isolation of Exosomes. | The expression of MUC1 protein on the exosomes isolated from MCF-7 cells also indicated that their potential diagnostic properties were intact. |
| 37547453 | Structural and molecular insight into antibody recognition of dynamic neoepitopes in membrane tethered MUC1 of pancreatic cancer cells and secreted exosomes. | No abstract available |
| 38006701 | DNA four-way junction-driven dual-rolling circle amplification sandwich-type aptasensor for ultra-sensitive and specific detection of tumor-derived exosomes. | The CD63 aptamer modified on a gold electrode captured exosomes, and then the sandwich-type aptasensor was formed with the addition of the MUC1 aptamer. |
| 39020428 | Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer. | No abstract available |
| 39243449 | Branched hybridization chain reaction and tetrahedral DNA-based trivalent aptamer powered SERS sensor for ultra-highly sensitive detection of cancer-derived exosomes. | Taking gastric cancer SGC-7901 cells-derived exosomes as a test model, the triApt-TDNs were constructed by conjugating aptamers specific to mucin 1 (MUC1) protein with tetrahedral DNAs and subsequently immobilized on the surface of silver nanorods (AgNRs) arrays to create SERS-active sensing chips capable of specifically capturing exosomes overexpressing MUC1 proteins. |