Protein detail

BEND6

BEN domain-containing protein 6

Entry name BEND6	UniProt ID Q5SZJ8	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

BEN domain-containing protein 6

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000151917

Entrez Gene Symbol

BEND6

Gene Synonym (3)

bA203B9.1C6orf65FLJ30162

Gene Description

BEN domain containing 6

Chromosome

Position

56955107-57027346

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Cell SpecificLate primary spermatocytesSecretome LocationSecreted to bloodSecretome FunctionOther

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005634 nucleus

Molecular Function (3)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence5

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	BEND6	Q5SZJ8	2	PDB	PDB:7yun

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Flow cytometryMORPHELISA	2	40784529 41216884

Sequence, Structure & Domains12

Sequences

Length

279

Mass

31,222

Sequence

MQKIVQTDEITNTQAFRKGKRKRTETMDSENANSDMDKGQRDPYSGNAFLPGESSSEDEEPLAELSKEELCAKIKSLKEKLTNTRKENSRLRQSLVMLQVLPQAVTQFEELVGMAEALLKGGGTMSTSASTLWRATNNSSPDSFASTCSNSNSNSSSPVSLKPEEEHQTDEKQFQIEKWQIARCNKSKPQKFINDLMQVLYTNEYMATHSLTGAKSSTSRDKAVKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNCTKKPNLSKNLNSQDIK

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5SZJ8-1; Sequence=Displayed; Name=2; IsoId=Q5SZJ8-2; Sequence=VSP_026963, VSP_026964; Name=3; IsoId=Q5SZJ8-3; Sequence=VSP_026961, VSP_026962; Name=4; IsoId=Q5SZJ8-4; Sequence=VSP_026965, VSP_026966

Alternative Sequence

1..98; Missing (in isoform 3); 99..100; QV -> ML (in isoform 3); 100..106; VLPQAVT -> AWSRELP (in isoform 2); 107..279; Missing (in isoform 2); 181..189; IARCNKSKP -> NPLLQGTKL (in isoform 4); 190..279; Missing (in isoform 4)

3D Structural Models

Helix

178..182; 189..200; 203..207; 230..243; 249..262

Beta Strand

210..212

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

1..15; Polar residues; 134..148; Polar residues; 162..172; Basic and acidic residues

Coiled Coil

62..99

Domain (FT)

171..271; BEN

Region

1..65; Disordered; 134..172; Disordered

Clinical Relevance1

Antibody (2)

HPA031605 HPA052973

Supporting Publications1

PMID	Title	Abstract
27487081	Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.	No abstract available