Protein detail

HYI

Putative hydroxypyruvate isomerase (EC 5.3.1.22) (Endothelial cell apoptosis protein E-CE1)

Entry name HYI	UniProt ID Q5T013	EVMP confidence score 0.53
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins

Basic Information

Protein Names

Putative hydroxypyruvate isomerase (EC 5.3.1.22) (Endothelial cell apoptosis protein E-CE1)

Protein Class (3)

EnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function (3)

Enzymes
ENZYME proteins:Isomerase
Predicted intracellular proteins

Ensembl

ENSG00000178922

Entrez Gene Symbol

HYI

Gene Synonym

HT036

Gene Description

Hydroxypyruvate isomerase (putative)

Chromosome

Position

43450989-43453989

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Function & Pathway

Protein Function (3)

Enzymes
ENZYME proteins:Isomerase
Predicted intracellular proteins

Cellular Component

GO:0005575 cellular_component

Molecular Function (3)

Biological Process (3)

KEGG (2)

Canonical Pathways (3)

M232 Pid ecadherin stabilization pathway
M71 Pid ilk pathway
M12 Pid rhoa pathway

Mediation Categories

Other mediation

Relations & Evidence11

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI
intracellular	intracellular	OmniPath

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster115	ABHD14A ACY1 HYI PRKRA TARBP2	O75569 Q03154 Q15633 Q5T013 Q9BUJ0	1:1:1:1:1	Compleat	Compleat:HC1361	22036573
	C11orf54 HYI TIMM44	O43615 Q5T013 Q9H0W9	0:0:0	hu.MAP2
	HYI KYAT3 LACTB2 PGM3	O95394 Q53H82 Q5T013 Q6YP21	0:0:0:0	hu.MAP
	HYI ITPA KYAT3 LACTB2 PGM3	O95394 Q53H82 Q5T013 Q6YP21 Q9BY32	0:0:0:0:0	hu.MAP
	HYI KYAT3 PGM3	O95394 Q5T013 Q6YP21	0:0:0	hu.MAP
	HYI ITPA KYAT3	Q5T013 Q6YP21 Q9BY32	0:0:0	hu.MAP2
	HYI ITPA	Q5T013 Q9BY32	0:0	hu.MAP2
	C11orf54 HYI	Q5T013 Q9H0W9	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
NA	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	37340044

Sequence, Structure & Domains

Sequences

Length

277

Mass

30,406

Sequence

MAPLRFSANLSWLFPELSGLPARVRAAGSSGFEAVEVAWPYAETPEALARAAREAGLRLVLINTPPGDQEKGEMGLGAVPGRQAAFREGLEQAVRYAKALGCPRIHLMAGRVPQGADRIAVKAEMEAVFLENLRHAAGVLAQEDLVGLLEPINTRITDPQYFLDTPQQAAAILQKVGRPNLQLQMDIFHWQIMDGNLTGNIREFLPIVGHVQVAQVPGRGEPSSPGELNFPYLFQLLEDEGYKGFVGCEYQPRGDTVEGLSWLRSYWDRRGHPEAGQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5T013-1; Sequence=Displayed; Name=2; IsoId=Q5T013-2; Sequence=VSP_025986, VSP_025987; Name=3; IsoId=Q5T013-3; Sequence=VSP_025987; Name=4; IsoId=Q5T013-4; Sequence=VSP_025986

Alternative Sequence

1..73; Missing (in isoform 2 and isoform 4); 248..277; Missing (in isoform 2 and isoform 3)

Domain & Motif Annotations

Protein Families

Hyi family

Sequence Similarities

Belongs to the hyi family.

Clinical Relevance

Antibody

HPA040092

Interaction Protein

ENSG00000120498

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Related sentences
37163338	Role of Gasdermin E in the Biogenesis of Apoptotic Cell-Derived Exosomes.	In apoptotic human HeLa and HEK293 cells, GSDMA, GSDMC, GSDMD, and GSDME increased the release of apoptotic exosomes.