Protein detail

HYI

Putative hydroxypyruvate isomerase (EC 5.3.1.22) (Endothelial cell apoptosis protein E-CE1)

Entry name HYI	UniProt ID Q5T013	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Putative hydroxypyruvate isomerase (EC 5.3.1.22) (Endothelial cell apoptosis protein E-CE1)

Protein Class (3)

EnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function (3)

Enzymes
ENZYME proteins:Isomerase
Predicted intracellular proteins

Ensembl

ENSG00000178922

Entrez Gene Symbol

HYI

Gene Synonym

HT036

Gene Description

Hydroxypyruvate isomerase (putative)

Chromosome

Position

43450989-43453989

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway7

Protein Function (3)

Enzymes
ENZYME proteins:Isomerase
Predicted intracellular proteins

Cellular Component

GO:0005575 cellular_component

Molecular Function (3)

Biological Process (3)

KEGG (2)

Canonical Pathways (3)

M232 Pid ecadherin stabilization pathway
M71 Pid ilk pathway
M12 Pid rhoa pathway

Mediation Categories

Other mediation

Relations & Evidence11

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster115	ABHD14A ACY1 HYI PRKRA TARBP2	O75569 Q03154 Q15633 Q5T013 Q9BUJ0	1:1:1:1:1	Compleat	Compleat:HC1361	22036573
	C11orf54 HYI TIMM44	O43615 Q5T013 Q9H0W9	0:0:0	hu.MAP2
	HYI KYAT3 LACTB2 PGM3	O95394 Q53H82 Q5T013 Q6YP21	0:0:0:0	hu.MAP
	HYI ITPA KYAT3 LACTB2 PGM3	O95394 Q53H82 Q5T013 Q6YP21 Q9BY32	0:0:0:0:0	hu.MAP
	HYI KYAT3 PGM3	O95394 Q5T013 Q6YP21	0:0:0	hu.MAP
	HYI ITPA KYAT3	Q5T013 Q6YP21 Q9BY32	0:0:0	hu.MAP2
	HYI ITPA	Q5T013 Q9BY32	0:0	hu.MAP2
	C11orf54 HYI	Q5T013 Q9H0W9	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
NA	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	37340044

Sequence, Structure & Domains7

Sequences

Length

277

Mass

30,406

Sequence

MAPLRFSANLSWLFPELSGLPARVRAAGSSGFEAVEVAWPYAETPEALARAAREAGLRLVLINTPPGDQEKGEMGLGAVPGRQAAFREGLEQAVRYAKALGCPRIHLMAGRVPQGADRIAVKAEMEAVFLENLRHAAGVLAQEDLVGLLEPINTRITDPQYFLDTPQQAAAILQKVGRPNLQLQMDIFHWQIMDGNLTGNIREFLPIVGHVQVAQVPGRGEPSSPGELNFPYLFQLLEDEGYKGFVGCEYQPRGDTVEGLSWLRSYWDRRGHPEAGQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5T013-1; Sequence=Displayed; Name=2; IsoId=Q5T013-2; Sequence=VSP_025986, VSP_025987; Name=3; IsoId=Q5T013-3; Sequence=VSP_025987; Name=4; IsoId=Q5T013-4; Sequence=VSP_025986

Alternative Sequence

1..73; Missing (in isoform 2 and isoform 4); 248..277; Missing (in isoform 2 and isoform 3)

Domain & Motif Annotations

Protein Families

Hyi family

Sequence Similarities

Belongs to the hyi family.

Clinical Relevance4

Antibody

HPA040092

Interaction Protein

ENSG00000120498

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
37163338	Role of Gasdermin E in the Biogenesis of Apoptotic Cell-Derived Exosomes.	In apoptotic human HeLa and HEK293 cells, GSDMA, GSDMC, GSDMD, and GSDME increased the release of apoptotic exosomes.