Protein detail

TM63B

Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B)

Entry name TM63B	UniProt ID Q5T3F8	EVMP confidence score 0.72
Supporting publications (n) 12	Transmembrane count 11	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

41..65; Helical; Name=TM0; 146..178; Helical; Name=TM1; 203..227; Helical; Name=TM2; 428..457; Helical; Name=TM3; 473..502; Helical; Name=TM4; 507..543; Helical; Name=TM5; 567..599; Helical; Name=TM6; 620..638; Helical; Name=TM7; 642..666; Helical; Name=TM8; 674..702; Helical; Name=TM9; 708..728; Helical; Name=TM10

Transmembrane Count

Ensembl

ENSG00000137216

Entrez Gene Symbol

TMEM63B

Gene Synonym (3)

C6orf110dJ421H19.2DKFZp434P0531

Gene Description

Transmembrane protein 63B

Chromosome

Position

44126914-44155519

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization5

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells

Function & Pathway5

Protein Function

Transporters:Transporter channels and pores

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence21

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	GO_Intercell	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	COA1 CTDP1 GPN1 GPN2 GPN3 MCFD2 MYZAP POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J2 POLR2K POLR2L RECQL5 RNGTT RPAP2 RPRD1A RPRD1B RPRD2 TMEM63B	O15514 O60942 O94762 P0CAP1 P19387 P19388 P24928 P30876 P36954 P52434 P52435 P53803 P61218 P62487 P62875 Q5T3F8 Q5VT52 Q8IXW5 Q8NI22 Q96P16 Q9GZM3 Q9GZY4 Q9H9Y4 Q9HCN4 Q9NQG5 Q9UHW5 Q9Y5B0	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	2	32795414 37033249

Sequence, Structure & Domains11

Sequences

Length

832

Mass

94,958

Sequence

MLPFLLATLGTTALNNSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADRLRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRPSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDPRSNGRPPTAAAVPKSAKYIAQVLQDSEVDGDGDGAPGSSGDEPPSSSSQDEELLMPPDALTDTDFQSCEDSLIENEIHQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5T3F8-1; Sequence=Displayed; Name=2; IsoId=Q5T3F8-2; Sequence=VSP_023889, VSP_023890; Name=3; IsoId=Q5T3F8-3; Sequence=VSP_023891, VSP_023892

Alternative Sequence

472..491; NPIITQFFPTLLLWCFSALL -> VRPHAPVTFHAGSQHTDTRP (in isoform 2); 492..832; Missing (in isoform 2); 704; G -> D (in isoform 3); 705..832; Missing (in isoform 3)

3D Structural Models

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

789..801; Low complexity

Motif

86..88; Mediates endoplasmic reticulum retention

Region

231..426; Intracellular linker IL2; confers mechanosensitivity; 567..599; Gating helix; 780..814; Disordered

Protein Families

CSC1 (TC 1.A.17) family

Sequence Similarities

Belongs to the CSC1 (TC 1.A.17) family.

Clinical Relevance4

Antibody (3)

HPA029249 HPA029250 HPA029251

Interaction Protein

ENSG00000117479

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications12

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
29320704	Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
30950185	Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39569406	Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.	No abstract available

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