Protein detail
TM63B
Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B)
Protein symbol TM63B | UniProt ID | EVMP score 0.72 |
Frequency 12 | Transmembrane count 11 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
41..65; Helical; Name=TM0; 146..178; Helical; Name=TM1; 203..227; Helical; Name=TM2; 428..457; Helical; Name=TM3; 473..502; Helical; Name=TM4; 507..543; Helical; Name=TM5; 567..599; Helical; Name=TM6; 620..638; Helical; Name=TM7; 642..666; Helical; Name=TM8; 674..702; Helical; Name=TM9; 708..728; Helical; Name=TM10
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
C6orf110dJ421H19.2DKFZp434P0531
Gene Description
Transmembrane protein 63B
Chromosome
6
Position
44126914-44155519
Frequency
12
EVMP Score
0.72
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| COA1CTDP1GPN1GPN2GPN3MCFD2MYZAPPOLR2APOLR2BPOLR2CPOLR2DPOLR2EPOLR2FPOLR2GPOLR2HPOLR2IPOLR2JPOLR2J2POLR2KPOLR2LRECQL5RNGTTRPAP2RPRD1ARPRD1BRPRD2TMEM63B | O15514O60942O94762P0CAP1P19387P19388P24928P30876P36954P52434P52435P53803P61218P62487P62875Q5T3F8Q5VT52Q8IXW5Q8NI22Q96P16Q9GZM3Q9GZY4Q9H9Y4Q9HCN4Q9NQG5Q9UHW5Q9Y5B0 | 0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
832
Mass
94,958
Sequence
MLPFLLATLGTTALNNSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADRLRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRPSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDPRSNGRPPTAAAVPKSAKYIAQVLQDSEVDGDGDGAPGSSGDEPPSSSSQDEELLMPPDALTDTDFQSCEDSLIENEIHQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5T3F8-1; Sequence=Displayed; Name=2; IsoId=Q5T3F8-2; Sequence=VSP_023889, VSP_023890; Name=3; IsoId=Q5T3F8-3; Sequence=VSP_023891, VSP_023892
Alternative Sequence
472..491; NPIITQFFPTLLLWCFSALL -> VRPHAPVTFHAGSQHTDTRP (in isoform 2); 492..832; Missing (in isoform 2); 704; G -> D (in isoform 3); 705..832; Missing (in isoform 3)
3D Structural Models
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
789..801; Low complexity
Motif
86..88; Mediates endoplasmic reticulum retention
Region
231..426; Intracellular linker IL2; confers mechanosensitivity; 567..599; Gating helix; 780..814; Disordered
Protein Families
CSC1 (TC 1.A.17) family
Sequence Similarities
Belongs to the CSC1 (TC 1.A.17) family.