Protein detail

TM63B

Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B)

Entry name TM63B	UniProt ID Q5T3F8	EVMP confidence score 0.72
Supporting publications (n) 12	Transmembrane count 11	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

41..65; Helical; Name=TM0; 146..178; Helical; Name=TM1; 203..227; Helical; Name=TM2; 428..457; Helical; Name=TM3; 473..502; Helical; Name=TM4; 507..543; Helical; Name=TM5; 567..599; Helical; Name=TM6; 620..638; Helical; Name=TM7; 642..666; Helical; Name=TM8; 674..702; Helical; Name=TM9; 708..728; Helical; Name=TM10

Transmembrane Count

Ensembl

ENSG00000137216

Entrez Gene Symbol

TMEM63B

Gene Synonym (3)

C6orf110dJ421H19.2DKFZp434P0531

Gene Description

Transmembrane protein 63B

Chromosome

Position

44126914-44155519

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization5

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells

Function & Pathway5

Protein Function

Transporters:Transporter channels and pores

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence21

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
tmem63_osmosensitive_cation	ion_channel	Almen2009	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	COA1 CTDP1 GPN1 GPN2 GPN3 MCFD2 MYZAP POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J2 POLR2K POLR2L RECQL5 RNGTT RPAP2 RPRD1A RPRD1B RPRD2 TMEM63B	O15514 O60942 O94762 P0CAP1 P19387 P19388 P24928 P30876 P36954 P52434 P52435 P53803 P61218 P62487 P62875 Q5T3F8 Q5VT52 Q8IXW5 Q8NI22 Q96P16 Q9GZM3 Q9GZY4 Q9H9Y4 Q9HCN4 Q9NQG5 Q9UHW5 Q9Y5B0	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	2	32795414 37033249

Sequence, Structure & Domains11

Sequences

Length

832

Mass

94,958

Sequence

MLPFLLATLGTTALNNSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADRLRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRPSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDPRSNGRPPTAAAVPKSAKYIAQVLQDSEVDGDGDGAPGSSGDEPPSSSSQDEELLMPPDALTDTDFQSCEDSLIENEIHQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5T3F8-1; Sequence=Displayed; Name=2; IsoId=Q5T3F8-2; Sequence=VSP_023889, VSP_023890; Name=3; IsoId=Q5T3F8-3; Sequence=VSP_023891, VSP_023892

Alternative Sequence

472..491; NPIITQFFPTLLLWCFSALL -> VRPHAPVTFHAGSQHTDTRP (in isoform 2); 492..832; Missing (in isoform 2); 704; G -> D (in isoform 3); 705..832; Missing (in isoform 3)

3D Structural Models

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

789..801; Low complexity

Motif

86..88; Mediates endoplasmic reticulum retention

Region

231..426; Intracellular linker IL2; confers mechanosensitivity; 567..599; Gating helix; 780..814; Disordered

Protein Families

CSC1 (TC 1.A.17) family

Sequence Similarities

Belongs to the CSC1 (TC 1.A.17) family.

Clinical Relevance4

Antibody (3)

HPA029249 HPA029250 HPA029251

Interaction Protein

ENSG00000117479

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications12

PMID	Title	Abstract
39766158	A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.	No abstract available
39940923	NHERF2 as a Novel Biomarker for Distinguishing MAC Pulmonary Disease from Tuberculosis Based on Proteome Analysis of Serum Extracellular Vesicles.	No abstract available

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