Protein detail
CXG2
Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein)
Protein symbol CXG2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein)
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Transmembrane
26..46; Helical; 79..99; Helical; 217..237; Helical; 266..286; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GJC2 | CDK2 | P24941 | S | 372 | phosphorylation | KEA | KEA:17570479 |
| GJC2 | GSK3B | P49841 | S | 372 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | No | No |
| gap_junction | gap_junction | GO_Intercell | Yes | Yes | No | No | No |
| gap_junction | gap_junction | Ramilowski_location | Yes | Yes | No | No | No |
| gap_junction | gap_junction | UniProt_location | Yes | Yes | No | No | No |
| gap_junction | gap_junction | Almen2009 | Yes | Yes | No | No | No |
| gap_junction | gap_junction | HGNC | Yes | Yes | No | No | No |
| gap_junction | gap_junction | UniProt_keyword | Yes | Yes | No | No | No |
| gap_junction | gap_junction | OmniPath | Yes | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 24196483 |
Sequence, Structure & Domains
Sequences
Length
439
Mass
47,002
Sequence
MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPRAGSEKGSASSRDGKTTVWI
3D Structural Models
Domain & Motif Annotations
Compositional Bias
112..125; Basic residues; 140..174; Acidic residues; 378..393; Low complexity
Region
108..178; Disordered; 364..439; Disordered
Protein Families
- Connexin family
- Gamma-type subfamily
Sequence Similarities
Belongs to the connexin family. Gamma-type subfamily.