Protein detail

CXG2

Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein)

Entry name
CXG2
UniProt ID
Q5T442
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
4
Protein classification
Basic Information
Protein Names
Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein)
Protein Function (4)
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Disease related genes
  • Human disease related genes:Congenital malformations:Congenital malformations of skin
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Transmembrane
26..46; Helical; 79..99; Helical; 217..237; Helical; 266..286; Helical
Transmembrane Count
4
Ensembl
ENSG00000198835
Entrez Gene Symbol
GJC2
Supporting publications (n)
1
EVMP confidence score
0.53
Function & Pathway
Protein Function (4)
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Disease related genes
  • Human disease related genes:Congenital malformations:Congenital malformations of skin
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Cellular Component (6)
Molecular Function (2)
Biological Process (3)
Reactome (4)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence23

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
GJC2CDK2P24941S372phosphorylationKEAKEA:17570479
GJC2GSK3BP49841S372phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling (20)

20 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
cell_surface_ligandcell_surface_ligandBaccin2019Yes
cell_surface_ligandcell_surface_ligandOmniPathYes
gap_junctiongap_junctionGO_IntercellYesYes
gap_junctiongap_junctionRamilowski_locationYesYes
gap_junctiongap_junctionUniProt_locationYesYes
gap_junctiongap_junctionAlmen2009YesYes
gap_junctiongap_junctionHGNCYesYes
gap_junctiongap_junctionUniProt_keywordYesYes
gap_junctiongap_junctionOmniPathYesYes
transmembranetransmembraneUniProt_location
Page 1 of 2Next

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry124196483
Sequence, Structure & Domains

Sequences

Length
439
Mass
47,002
Sequence
MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPRAGSEKGSASSRDGKTTVWI

Domain & Motif Annotations

Compositional Bias
112..125; Basic residues; 140..174; Acidic residues; 378..393; Low complexity
Region
108..178; Disordered; 364..439; Disordered
Protein Families (2)
  • Connexin family
  • Gamma-type subfamily
Sequence Similarities
Belongs to the connexin family. Gamma-type subfamily.
Supporting Publications1
PMIDTitleRelated sentences
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available