Protein detail

CXG2

Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein)

Entry name CXG2	UniProt ID Q5T442	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein)

Protein Function (4)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of skin
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism

Transmembrane

26..46; Helical; 79..99; Helical; 217..237; Helical; 266..286; Helical

Transmembrane Count

Ensembl

ENSG00000198835

Entrez Gene Symbol

GJC2

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway6

Protein Function (4)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of skin
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism

Cellular Component (6)

Molecular Function (2)

Biological Process (3)

Reactome (4)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence23

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GJC2	CDK2	P24941	S	372	phosphorylation	KEA	KEA:17570479
GJC2	GSK3B	P49841	S	372	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	No	No
gap_junction	gap_junction	GO_Intercell	Yes	Yes	No	No	No
gap_junction	gap_junction	Ramilowski_location	Yes	Yes	No	No	No
gap_junction	gap_junction	UniProt_location	Yes	Yes	No	No	No
gap_junction	gap_junction	Almen2009	Yes	Yes	No	No	No
gap_junction	gap_junction	HGNC	Yes	Yes	No	No	No
gap_junction	gap_junction	UniProt_keyword	Yes	Yes	No	No	No
gap_junction	gap_junction	OmniPath	Yes	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No

Page 1 of 2Next

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	24196483

Sequence, Structure & Domains7

Sequences

Length

439

Mass

47,002

Sequence

MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPRAGSEKGSASSRDGKTTVWI

Domain & Motif Annotations

Compositional Bias

112..125; Basic residues; 140..174; Acidic residues; 378..393; Low complexity

Region

108..178; Disordered; 364..439; Disordered

Protein Families (2)

Connexin family
Gamma-type subfamily

Sequence Similarities

Belongs to the connexin family. Gamma-type subfamily.

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available