Protein detail

RHG21

Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)

Entry name RHG21	UniProt ID Q5T5U3	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000107863

Entrez Gene Symbol

ARHGAP21

Gene Synonym (2)

ARHGAP10KIAA1424

Gene Description

Rho GTPase activating protein 21

Chromosome

Position

24583609-24723887

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificskeletal muscleCell SpecificEpicardial cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificneutrophil

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function (2)

Biological Process (3)

Reactome (15)

Page 1 of 2

Mediation Categories

Receptor-signaling mediation

Relations & Evidence8

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ARHGAP21	AURKB	Q96GD4	S	131	phosphorylation	MIMPPhosphoSitePhosphoSite_MIMP

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
RHG21	Q5T5U3	RHOA	P61586	Yes	No	Yes	HPRDSIGNOR	HPRD:15793564 SIGNOR:32203420

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARHGAP21 RPL13A RPL18A RPL27 RPL30 RPL36 RPS11 RPS14 RPS15A RPS17 RPS3A RPS7 RPS9 UBC	P08708 P0CG48 P40429 P46781 P61247 P61353 P62081 P62244 P62263 P62280 P62888 Q02543 Q5T5U3 Q9Y3U8	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5680

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	R SequencingMass spectrometry	13	40189497 37322475 36497184 41068253 33592500 32854315 38014595 31617158 36146834 33309826 37670049 38207106 39207047

Sequence, Structure & Domains11

Sequences

Length

1,958

Mass

217,462

Sequence

MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGFGFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQDAYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQPGRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEEVRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISSSRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSTTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGICERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQTTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSLLNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQEAETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIATVPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGDVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNVFFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPSEEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLARFSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEADDERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGSLTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKGKSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRRRHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTSTSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQINGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5T5U3-1; Sequence=Displayed; Name=3; IsoId=Q5T5U3-3; Sequence=VSP_028298, VSP_028300, VSP_028301

Alternative Sequence

166..175; Missing (in isoform 3); 1160..1175; YIPLIVDICCKLVEER -> VGDTSPPDFLKSLIQF (in isoform 3); 1176..1958; Missing (in isoform 3)

3D Structural Models

Helix

112..116; 137..145; 1025..1038; 1043..1063

Beta Strand

51..54; 57..59; 80..82; 109..111; 150..154; 934..944; 959..966; 969..974; 979..981; 984..986; 995..998; 1000..1002; 1006..1012; 1017..1021

3D Structure

NMR spectroscopy (2); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

13..32; Basic and acidic residues; 286..295; Polar residues; 306..325; Polar residues; 418..436; Polar residues; 448..458; Low complexity; 659..687; Polar residues; 729..742; Basic and acidic residues; 875..885; Basic and acidic residues; 1099..1122; Basic and acidic residues; 1349..1362; Polar residues; 1383..1401; Low complexity; 1441..1466; Basic and acidic residues; 1477..1493; Basic and acidic residues; 1544..1559; Low complexity; 1603..1612; Polar residues; 1624..1634; Basic and acidic residues; 1671..1686; Polar residues; 1874..1909; Polar residues; 1918..1931; Polar residues

Domain (FT)

50..159; PDZ; 931..1040; PH; 1147..1339; Rho-GAP

Region

1..42; Disordered; 286..325; Disordered; 418..458; Disordered; 659..751; Disordered; 859..885; Disordered; 930..1097; Interaction with ARF1 and ARF6; 1086..1133; Disordered; 1348..1401; Disordered; 1418..1575; Disordered; 1592..1861; Interaction with CTNNA1; 1598..1642; Disordered; 1655..1686; Disordered; 1860..1958; Disordered

Clinical Relevance4

Antibody (2)

HPA036610 HPA057861

Interaction Protein (3)

ENSG00000164924ENSG00000175793ENSG00000183248

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
40689422	Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.	No abstract available