Protein detail
PI3R6
Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)
Protein symbol PI3R6 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
C17orf38FLJ34500HsT41028p87PIKAP
Gene Description
Phosphoinositide-3-kinase regulatory subunit 6
Chromosome
17
Position
8802722-8867677
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificMegakaryocyte progenitorsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell SpecificNK-cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa05145 Toxoplasmosis
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-389357 cd28 dependent pi3k akt signaling
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-389356 co stimulation by cd28
- R-hsa-9927354 co stimulation by icos
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-114604 gpvi mediated activation cascade
- R-hsa-392451 g beta gamma signalling through pi3kgamma
- R-hsa-397795 g protein beta gamma signalling
- R-hsa-109582 hemostasis
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-556833 metabolism of lipids
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-1483257 phospholipid metabolism
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-1483255 pi metabolism
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-372790 signaling by gpcr
- R-hsa-1660499 synthesis of pips at the plasma membrane
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PIK3R6 | AKT1 | P31749 | T | 607 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AKT1 | P31749 | PI3R6 | Q5UE93 | Yes | Yes | No | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:25753393SIGNOR:25753393 |
| PI3R6 | Q5UE93 | COMPLEX:P27986_P42336 | Yes | No | Yes | SIGNOR | SIGNOR:25753393 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
754
Mass
84,258
Sequence
MESSDVELDLQRSVQAVLRELSTQAPALQSNQGMWRWSLHKKVERDPGKSPVLVRILLRELEKAESQDLRHVIIPLLHTVMYVLTKATGITEELYQRIYAFCTRLLTLPTPYCTVALDCAIRLKTEMAVPGTLYQRMVIAEQNLTNELYPYQERVFLFVDPELVSASVCSALLLEIEAAQAQQTPETCMRHVVSHALQAALGEACHAGALHRKLQASPRRTLEHYFHAVVAALEQMASEASPSREGHVERLEEIYCSLLGPAAGRCGGDLVQERPPSIPLPSPYITFHLWTGEEQLWKELVLFLRPRSQLRLSADLEVLDLQGLRPDRELARVSVLSTDSGIERDLPTGADELPAPGSPEMERAGLQRKGGIKKRAWPLDFLMPGSWDGPPGLHRRTGRPSGDGEMLPGVSRLHTARVLVLGDDRMLGRLAQAYHRLRKRETQKFCLTPRLSLQLYYIPVLAPEKPAASRQPELGELATFLGRVDPWYQSNVNTLCPAIHKLAEMPPSLDTSRTVDPFILDVITYYIRMGTQPIYFQIYTVKIFFSDLSQDPTEDIFLIELKVKIQDSKFPKDGFSPRRRGVAEGPGAELSLCYQKALLSHRPREVTVSLRATGLILKAIPASDTEVSGSSHCPLPAAPVTDHTCLNVNVTEVVKSSNLAGKSFSTVTNTFRTNNIQIQSRDQRLLTLSLDKDDQRTFRDVVRFEVAPCPEPCSGAQKSKAPWLNLHGQQEVEAIKAKPKPLLMPINTFSGIVQ
3D Structural Models
Domain & Motif Annotations
Region
343..363; Disordered