Protein detail
GFI1B
Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)
Protein symbol GFI1B | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsTranscription factors |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsTranscription factors
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Ensembl
Entrez Gene Symbol
Gene Synonym
ZNF163B
Gene Description
Growth factor independent 1B transcriptional repressor
Chromosome
9
Position
132944000-132991687
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Cellular Component
Molecular Function
- GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0005515 protein binding
- GO:0046872 metal ion binding
- GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
- GO:1990837 sequence-specific double-stranded DNA binding
Biological Process
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
330
Mass
37,492
Sequence
MPRSFLVKSKKAHTYHQPRVQEDEPLWPPALTPVPRDQAPSNSPVLSTLFPNQCLDWTNLKREPELEQDQNLARMAPAPEGPIVLSRPQDGDSPLSDSPPFYKPSFSWDTLATTYGHSYRQAPSTMQSAFLEHSVSLYGSPLVPSTEPALDFSLRYSPGMDAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=p37; IsoId=Q5VTD9-1; Sequence=Displayed; Name=2; Synonyms=p32; IsoId=Q5VTD9-2; Sequence=VSP_028459
Alternative Sequence
171..216; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Zinc Finger
163..186; C2H2-type 1; 192..214; C2H2-type 2; 220..242; C2H2-type 3; 248..270; C2H2-type 4; 276..298; C2H2-type 5; 304..327; C2H2-type 6
Domain (CC)
The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.; DOMAIN: The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.
Region
1..42; Disordered; 1..20; SNAG domain; 91..330; Interaction with ARIH2; 164..330; Mediates interaction with GATA1