Protein detail

GFI1B

Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)

Entry name GFI1B	UniProt ID Q5VTD9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsTranscription factors

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)

Protein Class (4)

Disease related genesHuman disease related genesPredicted intracellular proteinsTranscription factors

Protein Function (4)

Disease related genes
Human disease related genes:Cardiovascular diseases:Hematologic diseases
Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Ensembl

ENSG00000165702

Entrez Gene Symbol

GFI1B

Gene Synonym

ZNF163B

Gene Description

Growth factor independent 1B transcriptional repressor

Chromosome

Position

132944000-132991687

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificbone marrowCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway5

Protein Function (4)

Disease related genes
Human disease related genes:Cardiovascular diseases:Hematologic diseases
Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Cellular Component (5)

Molecular Function (7)

Biological Process (3)

Mediation Categories

Immune mediation

Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Gata1-Gfi1b complex	GATA1 GFI1B	P15976 Q5VTD9	1:1	Compleat	Compleat:HC3384	15920471

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	9	40829696 38731868 24505114 26801919 27723984 33709510 40098346 31588238 37309723

Sequence, Structure & Domains8

Sequences

Length

330

Mass

37,492

Sequence

MPRSFLVKSKKAHTYHQPRVQEDEPLWPPALTPVPRDQAPSNSPVLSTLFPNQCLDWTNLKREPELEQDQNLARMAPAPEGPIVLSRPQDGDSPLSDSPPFYKPSFSWDTLATTYGHSYRQAPSTMQSAFLEHSVSLYGSPLVPSTEPALDFSLRYSPGMDAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=p37; IsoId=Q5VTD9-1; Sequence=Displayed; Name=2; Synonyms=p32; IsoId=Q5VTD9-2; Sequence=VSP_028459

Alternative Sequence

171..216; Missing (in isoform 2)

Domain & Motif Annotations

Zinc Finger

163..186; C2H2-type 1; 192..214; C2H2-type 2; 220..242; C2H2-type 3; 248..270; C2H2-type 4; 276..298; C2H2-type 5; 304..327; C2H2-type 6

Domain (CC)

The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.; DOMAIN: The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.

Region

1..42; Disordered; 1..20; SNAG domain; 91..330; Interaction with ARIH2; 164..330; Mediates interaction with GATA1

Clinical Relevance5

Disease Involvement

Proto-oncogene

Antibody (2)

CAB004420 HPA006291

Interaction Protein (3)

ENSG00000151849ENSG00000184613ENSG00000184916

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available