Protein detail

DRC8

Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)

Entry name DRC8	UniProt ID Q5VUJ9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000203666

Entrez Gene Symbol

EFCAB2

Gene Synonym (3)

CFAP200DRC8MGC12458

Gene Description

EF-hand calcium binding domain 2

Chromosome

Position

244969682-245127164

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificadipose tissueCell SpecificConjunctival goblet cellsSecretome LocationSecreted in other tissuesSecretome FunctionNo annotated function

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence8

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Sac3-Thp	CETN2 CETN3 EFCAB2 ENY2 MCM3AP PCID2	O15182 O60318 P41208 Q5JVF3 Q5VUJ9 Q9NPA8	1:1:1:1:1:1	Compleat	Compleat:HC1316	15311284 12411502
	EFCAB2 IQCN KDM5C	P41229 Q5VUJ9 Q9H0B3	0:0:0	hu.MAP2
	EFCAB2 IQCN	Q5VUJ9 Q9H0B3	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingELISA	5	39290459 41227296 40784529 22106071 37686366

Sequence, Structure & Domains11

Sequences

Length

269

Mass

29,714

Sequence

MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGISQATGSAARWRTRRTGKGLGYNSDEIRPRTLLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEILLERKYRPIPEDVLLRAFEVLDSAKRGFLTKDELIKYMTEEDGVSLRRPG

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5VUJ9-1; Sequence=Displayed; Name=2; IsoId=Q5VUJ9-2; Sequence=VSP_021055, VSP_021056, VSP_021057; Name=3; IsoId=Q5VUJ9-3; Sequence=VSP_043273, VSP_043274

Alternative Sequence

1..136; Missing (in isoform 2); 1..8; MLGPGQVR -> MADEKDRE (in isoform 3); 9..144; Missing (in isoform 3); 137..144; MTVLWGTQ -> MADEKDRE (in isoform 2); 261..269; DGVSLRRPG -> GEPFSQEEMEEMLSAAIDPESNSINYKDYITMMVIDEN (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

54..76; Low complexity

Domain (FT)

150..185; EF-hand 1; 228..263; EF-hand 2

Region

1..113; Disordered

Protein Families

DRC8 family

Sequence Similarities

Belongs to the DRC8 family.

Clinical Relevance1

Antibody

HPA031206

Supporting Publications1

PMID	Title	Abstract
30865381	Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114.	No abstract available