Protein detail

DRC8

Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)

Protein symbol DRC8	UniProt ID Q5VUJ9	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000203666

Entrez Gene Symbol

EFCAB2

Gene Synonym

CFAP200DRC8MGC12458

Gene Description

EF-hand calcium binding domain 2

Chromosome

Position

244969682-245127164

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificadipose tissueCell SpecificConjunctival goblet cellsSecretome LocationSecreted in other tissuesSecretome FunctionNo annotated function

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Sac3-Thp	CETN2 CETN3 EFCAB2 ENY2 MCM3AP PCID2	O15182 O60318 P41208 Q5JVF3 Q5VUJ9 Q9NPA8	1:1:1:1:1:1	Compleat	Compleat:HC1316	15311284 12411502
	EFCAB2 IQCN KDM5C	P41229 Q5VUJ9 Q9H0B3	0:0:0	hu.MAP2
	EFCAB2 IQCN	Q5VUJ9 Q9H0B3	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingELISA	5	39290459 41227296 40784529 22106071 37686366

Sequence, Structure & Domains

Sequences

Length

269

Mass

29,714

Sequence

MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGISQATGSAARWRTRRTGKGLGYNSDEIRPRTLLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEILLERKYRPIPEDVLLRAFEVLDSAKRGFLTKDELIKYMTEEDGVSLRRPG

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5VUJ9-1; Sequence=Displayed; Name=2; IsoId=Q5VUJ9-2; Sequence=VSP_021055, VSP_021056, VSP_021057; Name=3; IsoId=Q5VUJ9-3; Sequence=VSP_043273, VSP_043274

Alternative Sequence

1..136; Missing (in isoform 2); 1..8; MLGPGQVR -> MADEKDRE (in isoform 3); 9..144; Missing (in isoform 3); 137..144; MTVLWGTQ -> MADEKDRE (in isoform 2); 261..269; DGVSLRRPG -> GEPFSQEEMEEMLSAAIDPESNSINYKDYITMMVIDEN (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

54..76; Low complexity

Domain (FT)

150..185; EF-hand 1; 228..263; EF-hand 2

Region

1..113; Disordered

Protein Families

DRC8 family

Sequence Similarities

Belongs to the DRC8 family.

Clinical Relevance

Antibody

HPA031206