Protein detail
DRC8
Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)
Entry name DRC8 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CFAP200DRC8MGC12458
Gene Description
EF-hand calcium binding domain 2
Chromosome
1
Position
244969682-245127164
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificConjunctival goblet cellsSecretome LocationSecreted in other tissuesSecretome FunctionNo annotated function
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence8
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Sac3-Thp | CETN2CETN3EFCAB2ENY2MCM3APPCID2 | O15182O60318P41208Q5JVF3Q5VUJ9Q9NPA8 | 1:1:1:1:1:1 | Compleat | Compleat:HC1316 | 1531128412411502 |
| EFCAB2IQCNKDM5C | P41229Q5VUJ9Q9H0B3 | 0:0:0 | hu.MAP2 | |||
| EFCAB2IQCN | Q5VUJ9Q9H0B3 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
269
Mass
29,714
Sequence
MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGISQATGSAARWRTRRTGKGLGYNSDEIRPRTLLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEILLERKYRPIPEDVLLRAFEVLDSAKRGFLTKDELIKYMTEEDGVSLRRPG
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5VUJ9-1; Sequence=Displayed; Name=2; IsoId=Q5VUJ9-2; Sequence=VSP_021055, VSP_021056, VSP_021057; Name=3; IsoId=Q5VUJ9-3; Sequence=VSP_043273, VSP_043274
Alternative Sequence
1..136; Missing (in isoform 2); 1..8; MLGPGQVR -> MADEKDRE (in isoform 3); 9..144; Missing (in isoform 3); 137..144; MTVLWGTQ -> MADEKDRE (in isoform 2); 261..269; DGVSLRRPG -> GEPFSQEEMEEMLSAAIDPESNSINYKDYITMMVIDEN (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
54..76; Low complexity
Domain (FT)
150..185; EF-hand 1; 228..263; EF-hand 2
Region
1..113; Disordered
Protein Families
DRC8 family
Sequence Similarities
Belongs to the DRC8 family.
Clinical Relevance
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 30865381 | Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114. | No related sentences available |