Protein detail

MLIP

Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein)

Entry name MLIP	UniProt ID Q5VWP3	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein)

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000146147

Entrez Gene Symbol

MLIP

Gene Synonym (3)

C6orf142CIPMGC18257

Gene Description

Muscular LMNA interacting protein

Chromosome

Position

53929982-54266280

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecificliverCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence7

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry；Western blotting	2	40829696 40098346

Sequence, Structure & Domains7

Sequences

Length

993

Mass

105,914

Sequence

MLSEQGLLSDCGNNYFQMTSCILSGSIQTTPQVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNRSKSNDYLTLNAGSQQERDQAKLTCPSEVSGTILQEREFEANKLQGMQQSDLFKAEYVLIVDSEGEDEAASRKVEQGPPGGIGTAAVRPKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMAPQQKHGQLTSSPTTSEQLACKPPAFSFVSPTNPNTPPDPVNLEGASVLEEFHTRRLDVGGAVVEESATYFQTTAHSTPFSASKGTSSTLLFPHSTQLSGSNLPSSTAADPKPGLTSEVLKKTTLTSHVLSHGESPRTSSSPPSSSASLKSNSASYIPVRIVTHSLSPSPKPFTSSFHGSSSTICSQMSSSGNLSKSGVKSPVPSRLALLTAILKSNPSHQRPFSPASCPTFSLNSPASSTLTLDQKEKQTPPTPKKSLSSCSLRAGSPDQGELQVSELTQQSFHLPVFTKSTPLSQAPSLSPTKQASSSLASMNVERTPSPTLKSNTMLSLLQTSTSSSVGLPPVPPSSSLSSLKSKQDGDLRGPENPRNIHTYPSTLASSALSSLSPPINQRATFSSSEKCFHPSPALSSLINRSKRASSQLSGQELNPSALPSLPVSSADFASLPNLRSSSLPHANLPTLVPQLSPSALHPHCGSGTLPSRLGKSESTTPNHRSPVSTPSLPISLTRTEELISPCALSMSTGPENKKSKQYKTKSSYKAFAAIPTNTLLLEQKALDEPAKTESVSKDNTLEPPVELYFPAQLRQQTEELCATIDKVLQDSLSMHSSDSPSRSPKTLLGSDTVKTPTTLPRAAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKEEEVYEPNPFSKYLEDNSDLFSEQDVTVPPKPVSLHPLYQTKLYPPAKSLLHPQTLSHADCLAPGPFSHLSFSLSDEQENSHTLLSHNACNKLSHPMVAIPEHEALDSKEQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=3; IsoId=Q5VWP3-3; Sequence=Displayed; Name=1; IsoId=Q5VWP3-1; Sequence=VSP_061853, VSP_061855; Name=2; IsoId=Q5VWP3-2; Sequence=VSP_061852, VSP_061854, VSP_061857; Name=4; IsoId=Q5VWP3-4; Sequence=VSP_061853, VSP_061856

Alternative Sequence

1..84; MLSEQGLLSDCGNNYFQMTSCILSGSIQTTPQVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNR -> MCSWYLGFECS (in isoform 2); 1..32; MLSEQGLLSDCGNNYFQMTSCILSGSIQTTPQ -> MELEKREKRSLLNKNLEEKLT (in isoform 1 and isoform 4); 216..833; Missing (in isoform 2); 216..739; Missing (in isoform 1); 907..993; DVTVPPKPVSLHPLYQTKLYPPAKSLLHPQTLSHADCLAPGPFSHLSFSLSDEQENSHTLLSHNACNKLSHPMVAIPEHEALDSKEQ -> AAHSVDSYCNGSDTSGPWLL (in isoform 4); 907..974; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

80..90; Polar residues; 212..225; Polar residues; 300..315; Polar residues; 343..358; Low complexity; 500..532; Polar residues; 533..563; Low complexity; 564..574; Basic and acidic residues; 695..711; Polar residues; 811..822; Low complexity; 849..864; Polar residues

Region

1..51; Interaction with LMNA; 71..90; Disordered; 152..171; Disordered; 161..837; Required for interaction with ISL1; 186..225; Disordered; 231..250; Disordered; 300..322; Disordered; 334..358; Disordered; 443..481; Disordered; 500..582; Disordered; 677..711; Disordered; 811..864; Disordered

Clinical Relevance2

Disease Involvement

Disease variant

Antibody (3)

HPA029252 HPA046654 HPA077663

Supporting Publications2

PMID	Title	Abstract
36362114	Extracellular Vesicles in Diffuse Large B Cell Lymphoma: Characterization and Diagnostic Potential.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available