Protein detail

MLIP

Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein)

Protein symbol MLIP	UniProt ID Q5VWP3	EVMP score 0.50
Frequency 2	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein)

Protein Class

Disease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000146147

Entrez Gene Symbol

MLIP

Gene Synonym

C6orf142CIPMGC18257

Gene Description

Muscular LMNA interacting protein

Chromosome

Position

53929982-54266280

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificliverCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry；Western blotting	2	40829696 40098346

Sequence, Structure & Domains

Sequences

Length

993

Mass

105,914

Sequence

MLSEQGLLSDCGNNYFQMTSCILSGSIQTTPQVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNRSKSNDYLTLNAGSQQERDQAKLTCPSEVSGTILQEREFEANKLQGMQQSDLFKAEYVLIVDSEGEDEAASRKVEQGPPGGIGTAAVRPKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMAPQQKHGQLTSSPTTSEQLACKPPAFSFVSPTNPNTPPDPVNLEGASVLEEFHTRRLDVGGAVVEESATYFQTTAHSTPFSASKGTSSTLLFPHSTQLSGSNLPSSTAADPKPGLTSEVLKKTTLTSHVLSHGESPRTSSSPPSSSASLKSNSASYIPVRIVTHSLSPSPKPFTSSFHGSSSTICSQMSSSGNLSKSGVKSPVPSRLALLTAILKSNPSHQRPFSPASCPTFSLNSPASSTLTLDQKEKQTPPTPKKSLSSCSLRAGSPDQGELQVSELTQQSFHLPVFTKSTPLSQAPSLSPTKQASSSLASMNVERTPSPTLKSNTMLSLLQTSTSSSVGLPPVPPSSSLSSLKSKQDGDLRGPENPRNIHTYPSTLASSALSSLSPPINQRATFSSSEKCFHPSPALSSLINRSKRASSQLSGQELNPSALPSLPVSSADFASLPNLRSSSLPHANLPTLVPQLSPSALHPHCGSGTLPSRLGKSESTTPNHRSPVSTPSLPISLTRTEELISPCALSMSTGPENKKSKQYKTKSSYKAFAAIPTNTLLLEQKALDEPAKTESVSKDNTLEPPVELYFPAQLRQQTEELCATIDKVLQDSLSMHSSDSPSRSPKTLLGSDTVKTPTTLPRAAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKEEEVYEPNPFSKYLEDNSDLFSEQDVTVPPKPVSLHPLYQTKLYPPAKSLLHPQTLSHADCLAPGPFSHLSFSLSDEQENSHTLLSHNACNKLSHPMVAIPEHEALDSKEQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=3; IsoId=Q5VWP3-3; Sequence=Displayed; Name=1; IsoId=Q5VWP3-1; Sequence=VSP_061853, VSP_061855; Name=2; IsoId=Q5VWP3-2; Sequence=VSP_061852, VSP_061854, VSP_061857; Name=4; IsoId=Q5VWP3-4; Sequence=VSP_061853, VSP_061856

Alternative Sequence

1..84; MLSEQGLLSDCGNNYFQMTSCILSGSIQTTPQVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNR -> MCSWYLGFECS (in isoform 2); 1..32; MLSEQGLLSDCGNNYFQMTSCILSGSIQTTPQ -> MELEKREKRSLLNKNLEEKLT (in isoform 1 and isoform 4); 216..833; Missing (in isoform 2); 216..739; Missing (in isoform 1); 907..993; DVTVPPKPVSLHPLYQTKLYPPAKSLLHPQTLSHADCLAPGPFSHLSFSLSDEQENSHTLLSHNACNKLSHPMVAIPEHEALDSKEQ -> AAHSVDSYCNGSDTSGPWLL (in isoform 4); 907..974; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

80..90; Polar residues; 212..225; Polar residues; 300..315; Polar residues; 343..358; Low complexity; 500..532; Polar residues; 533..563; Low complexity; 564..574; Basic and acidic residues; 695..711; Polar residues; 811..822; Low complexity; 849..864; Polar residues

Region

1..51; Interaction with LMNA; 71..90; Disordered; 152..171; Disordered; 161..837; Required for interaction with ISL1; 186..225; Disordered; 231..250; Disordered; 300..322; Disordered; 334..358; Disordered; 443..481; Disordered; 500..582; Disordered; 677..711; Disordered; 811..864; Disordered

Clinical Relevance

Disease Involvement

Disease variant

Antibody

HPA029252 HPA046654 HPA077663