Protein detail

SPAT1

Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2)

Protein symbol SPAT1	UniProt ID Q5VX52	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000122432

Entrez Gene Symbol

SPATA1

Frequency

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0001669 acrosomal vesicle

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

7 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ALG5 AP3B2 CCDC126 EDA FITM2 GPM6A MFF MGAT5 SPATA19	P51674 Q09328 Q13367 Q7Z5L4 Q8N6M3 Q92838 Q96EE4 Q9GZY8 Q9Y673	0:0:0:0:0:0:0:0:0	hu.MAP2
CCDC126 FITM2 GPM6A MFF MGAT5 SPATA19	P51674 Q09328 Q7Z5L4 Q8N6M3 Q96EE4 Q9GZY8	0:0:0:0:0:0	hu.MAP2
CCDC126 GPM6A MFF SPATA19	P51674 Q7Z5L4 Q96EE4 Q9GZY8	0:0:0:0	hu.MAP2
SCYL2 SPATA1	Q5VX52 Q6P3W7	0:0	hu.MAP2
SCYL2 SPATA1 WNK1 WNK2	Q5VX52 Q6P3W7 Q9H4A3 Q9Y3S1	0:0:0:0	hu.MAP2
SCYL2 SPATA1 WNK2	Q5VX52 Q6P3W7 Q9Y3S1	0:0:0	hu.MAP2
CCDC126 MFF SPATA19	Q7Z5L4 Q96EE4 Q9GZY8	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	38225453

Sequence, Structure & Domains

Sequences

Length

459

Mass

52,946

Sequence

MKKDKKRNKIPIDNYPIQTLVNMSLNPSRPSSSELVELHVFYVPEGSWNYKLNTISTEVVNKFISAGFLRVSPQLTLRALRERLGEFLGEDAIAEKFLFLKCIGNNLAVVKEKQESELKLKSFAPPYALQPELYLLPVMDHLGNVYSPSTVILDERQTNNGVNEADGTIHRPISVTLFKEELGRDPSLLENTLKELPNKNQEEAGGKATAEKSQIAKNQIGNSELPGSLEDSNNDCFGTKKSQCLWENEDDTAISRRQDNQTAEKEYITLPDHPSLPCQPVLSSGITDISLLQTEREKIIKQMKQVKEERRYLERNREELVKTVEKLFEQSKLKRYHAYNGWKKKYLETKKVTASMEEVLTKLREDLELYYKKLLMQLEAREIKMRPKNLANITDSKNYLIIQITEVQHAIDQLKRKLDTDKMKLIVEVKMRKQAVSDLRTLKTELAQKKKIIHLYNLN

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5VX52-1; Sequence=Displayed; Name=2; IsoId=Q5VX52-2; Sequence=VSP_035223, VSP_035224; Name=3; IsoId=Q5VX52-4; Sequence=VSP_039875

Alternative Sequence

243..284; QCLWENEDDTAISRRQDNQTAEKEYITLPDHPSLPCQPVLSS -> VFGKMKMIQLSVEDRTIRQLKKSTSPYQITLHFLVNLFFLQE (in isoform 2); 285..459; Missing (in isoform 2); 359..459; Missing (in isoform 3)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

193..205; Basic and acidic residues

Coiled Coil

287..374; 400..453

Region

193..213; Disordered

Clinical Relevance