Protein detail

NAA35

N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog)

Entry name NAA35	UniProt ID Q5VZE5	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog)

Protein Class (3)

Essential proteinsPlasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000135040

Entrez Gene Symbol

NAA35

Gene Synonym (4)

bA379P1.1FLJ21613FLJ22643MAK10

Gene Description

N-alpha-acetyltransferase 35, NatC auxiliary subunit

Chromosome

Position

85941146-86025462

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSecretome LocationSecreted to bloodSecretome FunctionTransport

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (4)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence10

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
NatC	NAA30 NAA35 NAA38	Q147X3 Q5VZE5 Q9BRA0	1:1:1	SIGNORCompleatComplexPortalPDB	Compleat:HC1408intact:EBI-26377596PDB:7mx2SIGNOR:SIGNOR-C417	36638802 14755292 10504710 19398576
	DNAJB9 GTF2F1 GTF2F2 NAA35 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2G POLR2H POLR2J POLR2K TCEA1 TCEA2	O15514 P13984 P19387 P19388 P23193 P24928 P30876 P35269 P52434 P52435 P53803 P62487 Q15560 Q5VZE5 Q9UBS3	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6095
	NAA30 NAA35	Q147X3 Q5VZE5	1:1	PDB	PDB:7rb3

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	40326690

Sequence, Structure & Domains13

Sequences

Length

725

Mass

83,639

Sequence

MVMKASVDDDDSGWELSMPEKMEKSNTNWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAIKDGTIKIKDLTLPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEEDFQSMTYGFKMANSVTDLRVTGMLKDVEDDMQRRVKSTRSRQGEERDPEVELEHQQCLAVFSRVKFTRVLLTVLIAFTKKETSAVAEAQKLMVQAADLLSAIHNSLHHGIQAQNDTTKGDHPIMMGFEPLVNQRLLPPTFPRYAKIIKREEMVNYFARLIDRIKTVCEVVNLTNLHCILDFFCEFSEQSPCVLSRSLLQTTFLVDNKKVFGTHLMQDMVKDALRSFVSPPVLSPKCYLYNNHQAKDCIDSFVTHCVRPFCSLIQIHGHNRARQRDKLGHILEEFATLQDEAEKVDAALHTMLLKQEPQRQHLACLGTWVLYHNLRIMIQYLLSGFELELYSMHEYYYIYWYLSEFLYAWLMSTLSRADGSQMAEERIMEEQQKGRSSKKTKKKKKVRPLSREITMSQAYQNMCAGMFKTMVAFDMDGKVRKPKFELDSEQVRYEHRFAPFNSVMTPPPVHYLQFKEMSDLNKYSPPPQSPELYVAASKHFQQAKMILENIPNPDHEVNRILKVAKPNFVVMKLLAGGHKKESKVPPEFDFSAHKYFPVVKLV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5VZE5-1; Sequence=Displayed; Name=2; IsoId=Q5VZE5-2; Sequence=VSP_056098, VSP_056099

Alternative Sequence

293..294; DH -> GL (in isoform 2); 295..725; Missing (in isoform 2)

3D Structural Models

Turn

91..93; 125..131; 383..385; 411..413; 415..417; 698..702

Helix

86..90; 102..120; 133..136; 138..140; 144..167; 190..210; 222..249; 256..259; 262..277; 323..340; 341..344; 348..360; 365..375; 388..399; 403..405; 418..440; 445..474; 488..509; 515..517; 518..527; 529..547; 573..599; 612..619; 621..625; 634..641; 652..670; 678..697

Beta Strand

252..254; 643..648; 710..712; 717..719; 721..723

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

558..571; Basic residues

Region

548..573; Disordered

Protein Families

MAK10 family

Sequence Similarities

Belongs to the MAK10 family.

Clinical Relevance1

Antibody

HPA021547

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available