Protein detail
NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog)
Entry name NAA35 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog)
Protein Class (3)
Essential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
bA379P1.1FLJ21613FLJ22643MAK10
Gene Description
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Chromosome
9
Position
85941146-86025462
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSecretome LocationSecreted to bloodSecretome FunctionTransport
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function
Biological Process (3)
Reactome (4)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence10
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| NatC | NAA30NAA35NAA38 | Q147X3Q5VZE5Q9BRA0 | 1:1:1 | SIGNORCompleatComplexPortalPDB | Compleat:HC1408intact:EBI-26377596PDB:7mx2SIGNOR:SIGNOR-C417 | 36638802147552921050471019398576 |
| DNAJB9GTF2F1GTF2F2NAA35POLR2APOLR2BPOLR2CPOLR2DPOLR2EPOLR2GPOLR2HPOLR2JPOLR2KTCEA1TCEA2 | O15514P13984P19387P19388P23193P24928P30876P35269P52434P52435P53803P62487Q15560Q5VZE5Q9UBS3 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6095 | ||
| NAA30NAA35 | Q147X3Q5VZE5 | 1:1 | PDB | PDB:7rb3 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryMass spectrometry [LTQ-FT Ultra] | 1 | 40326690 |
Sequence, Structure & Domains
Sequences
Length
725
Mass
83,639
Sequence
MVMKASVDDDDSGWELSMPEKMEKSNTNWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAIKDGTIKIKDLTLPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEEDFQSMTYGFKMANSVTDLRVTGMLKDVEDDMQRRVKSTRSRQGEERDPEVELEHQQCLAVFSRVKFTRVLLTVLIAFTKKETSAVAEAQKLMVQAADLLSAIHNSLHHGIQAQNDTTKGDHPIMMGFEPLVNQRLLPPTFPRYAKIIKREEMVNYFARLIDRIKTVCEVVNLTNLHCILDFFCEFSEQSPCVLSRSLLQTTFLVDNKKVFGTHLMQDMVKDALRSFVSPPVLSPKCYLYNNHQAKDCIDSFVTHCVRPFCSLIQIHGHNRARQRDKLGHILEEFATLQDEAEKVDAALHTMLLKQEPQRQHLACLGTWVLYHNLRIMIQYLLSGFELELYSMHEYYYIYWYLSEFLYAWLMSTLSRADGSQMAEERIMEEQQKGRSSKKTKKKKKVRPLSREITMSQAYQNMCAGMFKTMVAFDMDGKVRKPKFELDSEQVRYEHRFAPFNSVMTPPPVHYLQFKEMSDLNKYSPPPQSPELYVAASKHFQQAKMILENIPNPDHEVNRILKVAKPNFVVMKLLAGGHKKESKVPPEFDFSAHKYFPVVKLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5VZE5-1; Sequence=Displayed; Name=2; IsoId=Q5VZE5-2; Sequence=VSP_056098, VSP_056099
Alternative Sequence
293..294; DH -> GL (in isoform 2); 295..725; Missing (in isoform 2)
3D Structural Models
Turn
91..93; 125..131; 383..385; 411..413; 415..417; 698..702
Helix
86..90; 102..120; 133..136; 138..140; 144..167; 190..210; 222..249; 256..259; 262..277; 323..340; 341..344; 348..360; 365..375; 388..399; 403..405; 418..440; 445..474; 488..509; 515..517; 518..527; 529..547; 573..599; 612..619; 621..625; 634..641; 652..670; 678..697
Beta Strand
252..254; 643..648; 710..712; 717..719; 721..723
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
558..571; Basic residues
Region
548..573; Disordered
Protein Families
MAK10 family
Sequence Similarities
Belongs to the MAK10 family.
Clinical Relevance
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |