Protein detail
CARL1
F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)
Protein symbol CARL1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CARMILdJ501N12.1FLJ20048LRRC16LRRC16A
Gene Description
Capping protein regulator and myosin 1 linker 1
Chromosome
6
Position
25279078-25620530
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificAdipocytesSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
1,371
Mass
151,557
Sequence
MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSAERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLESMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEELTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSLRQEKRSSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMGRVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQEKRAACAQKKLGNDAVSQDSSSPALSGVERSDGGGAVPKLHPGLPENRFGLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKSNDSGEEAEKEFIFV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CARMIL1a; IsoId=Q5VZK9-1; Sequence=Displayed; Name=2; IsoId=Q5VZK9-2; Sequence=VSP_032420; Name=3; IsoId=Q5VZK9-3; Sequence=VSP_032418, VSP_032419; Name=4; IsoId=Q5VZK9-4; Sequence=VSP_032415, VSP_032416, VSP_032417
Alternative Sequence
1..161; Missing (in isoform 4); 292..337; GVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTAS -> ETTTKIKRQNVPTVLQTYLVVCPSDYQPCPLPLGKDNYYSDFSHDG (in isoform 4); 338..1371; Missing (in isoform 4); 486..499; SLDISDNGLESDLS -> QLGTRYRNAVLRVY (in isoform 3); 500..1371; Missing (in isoform 3); 1177..1221; Missing (in isoform 2)
3D Structural Models
Helix
985..988; 1026..1029
Beta Strand
978..980; 999..1002
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
977..986; Basic and acidic residues; 1036..1061; Basic and acidic residues; 1106..1130; Basic and acidic residues; 1139..1148; Basic and acidic residues; 1190..1199; Polar residues; 1231..1243; Basic and acidic residues; 1244..1265; Low complexity; 1313..1326; Polar residues; 1340..1353; Basic and acidic residues
Repeat
245..269; LRR 1; 275..298; LRR 2; 304..327; LRR 3; 336..363; LRR 4; 391..418; LRR 5; 423..447; LRR 6; 481..506; LRR 7; 543..566; LRR 8; 570..593; LRR 9; 654..678; LRR 10; 958..981; LRR 11
Coiled Coil
710..734
Domain (CC)
The C-terminus is necessary for localization to the cell membrane (PubMed:26578515).
Region
957..1000; Disordered; 958..1082; Inhibits capping activity of CAPZA2; 1036..1159; Disordered; 1055..1089; Necessary for localization at the cell membrane; 1172..1371; Disordered
Protein Families
CARMIL family
Sequence Similarities
Belongs to the CARMIL family.