Protein detail

ZDH20

Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20)

Entry name ZDH20	UniProt ID Q5W0Z9	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification EnzymesMetabolic proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20)

Protein Class (4)

EnzymesMetabolic proteinsPredicted membrane proteinsTransporters

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Transporters:Accessory Factors Involved in Transport

Transmembrane

15..35; Helical; 54..74; Helical; 170..190; Helical; 208..231; Helical

Transmembrane Count

Ensembl

ENSG00000180776

Entrez Gene Symbol

ZDHHC20

Gene Synonym (2)

DHHC20FLJ25952

Gene Description

Zinc finger DHHC-type palmitoyltransferase 20

Chromosome

Position

21348784-21459370

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway6

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Transporters:Accessory Factors Involved in Transport

Cellular Component (9)

Molecular Function (6)

Biological Process (3)

Reactome (7)

Mediation Categories

Clinical-translation mediation

Relations & Evidence17

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ALG11 ARF1 COPE SACM1L VAPB ZDHHC20	O14579 O95292 P84077 Q2TAA5 Q5W0Z9 Q9NTJ5	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4097
DKC1 NOP10 SHQ1 UBC WDR48 ZDHHC20	O60832 P0CG48 Q5W0Z9 Q6PI26 Q8TAF3 Q9NPE3	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7210
CAND1 COPS2 COPS3 COPS4 COPS6 COPS7B CUL1 CUL2 CUL3 CUL4A CUL4B DDB1 RBX1 ZDHHC20	P61201 P62877 Q13616 Q13617 Q13618 Q13619 Q13620 Q16531 Q5W0Z9 Q7L5N1 Q86VP6 Q9BT78 Q9H9Q2 Q9UNS2	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3679
ZDHHC20	Q5W0Z9	2	PDB	PDB:7khmPDB:6bmmPDB:6bmlPDB:6bmn

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	R Sequencing	6	32795414 38731868 26775013 33709510 27312428 38490958

Sequence, Structure & Domains13

Sequences

Length

365

Mass

42,278

Sequence

MAPWTLWRCCQRVVGWVPVLFITFVVVWSYYAYVVELCVFTIFGNEENGKTVVYLVAFHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQEILRRAARALPIYTTSASKTIRYCEKCQLIKPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLFLLYSLLYCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFISVLSLFSYHCWLVGKNRTTIESFRAPTFSYGPDGNGFSLGCSKNWRQVFGDEKKYWLLPIFSSLGDGCSFPTRLVGMDPEQASVTNQNEYARSSGSNQPFPIKPLSESKNRLLDSESQWLENGAEEGIVKSGTNNHVTVAIEN

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5W0Z9-1; Sequence=Displayed; Name=2; IsoId=Q5W0Z9-2; Sequence=VSP_016276, VSP_016277; Name=3; IsoId=Q5W0Z9-3; Sequence=VSP_040481, VSP_040482; Name=4; IsoId=Q5W0Z9-4; Sequence=VSP_056002

Alternative Sequence

124..130; TIRYCEK -> SLMQSTK (in isoform 2); 131..365; Missing (in isoform 2); 315..365; SSGSNQPFPIKPLSESKNRLLDSESQWLENGAEEGIVKSGTNNHVTVAIEN -> RSKLQR (in isoform 4); 315; Missing (in isoform 3); 355..365; TNNHVTVAIEN -> V (in isoform 3)

3D Structural Models

Turn

43..46; 112..115; 129..132; 143..146; 165..167; 256..259

Helix

7..14; 17..34; 35..42; 48..74; 82..84; 90..96; 100..111; 157..159; 168..197; 204..237; 241..245; 263..271; 275..277

Beta Strand

140..142; 147..149; 154..156; 161..164; 280..282; 295..297

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Domain (CC)

The DHHC domain is required for palmitoyltransferase activity.

Domain (FT)

126..176; DHHC

Protein Families

DHHC palmitoyltransferase family

Sequence Similarities

Belongs to the DHHC palmitoyltransferase family.

Clinical Relevance1

Antibody (2)

HPA014483 HPA014702

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available