Protein detail

TBC9B

TBC1 domain family member 9B

Protein symbol TBC9B	UniProt ID Q66K14	EVMP score 0.50
Frequency 5	Transmembrane count 1	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

TBC1 domain family member 9B

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Transmembrane

668..688; Helical

Transmembrane Count

Ensembl

ENSG00000197226

Entrez Gene Symbol

TBC1D9B

Gene Synonym

GRAMD9BKIAA0676

Gene Description

TBC1 domain family member 9B

Chromosome

Position

179862066-179907897

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificgallbladderCell SpecificCholangiocytesSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0016020 membrane

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CHM CHML HSPA1B RAB1A RAB32 RAB3A RAB4A RAB5A RAB6A RAB7A RABAC1 RABGGTB TBC1D9B YIF1A	O95070 P0DMV9 P20336 P20338 P20339 P20340 P24386 P26374 P51149 P53611 P62820 Q13637 Q66K14 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8849
CPT1A PIP4P2 TBC1D9 TBC1D9B	P50416 Q66K14 Q6ZT07 Q8N4L2	0:0:0:0	hu.MAP2
TBC1D9 TBC1D9B	Q66K14 Q6ZT07	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	R Sequencing	1	30646616

Sequence, Structure & Domains

Sequences

Length

1,250

Mass

140,525

Sequence

MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLASDLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCATEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPSQLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q66K14-1; Sequence=Displayed; Name=2; IsoId=Q66K14-2; Sequence=VSP_025699

Alternative Sequence

955..971; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

414..443; Polar residues; 984..999; Basic and acidic residues

Domain (CC)

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.

Domain (FT)

142..209; GRAM 1; 288..356; GRAM 2; 508..695; Rab-GAP TBC; 879..914; EF-hand

Region

397..443; Disordered; 974..999; Disordered; 1069..1093; Disordered; 1128..1157; Disordered

Clinical Relevance

Antibody

HPA038350