Protein detail
MUC17
Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3)
Protein symbol MUC17 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 1 | Protein classification Cancer-related genesPredicted membrane proteins |
Basic Information
Protein Names
Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3)
Protein Class
Cancer-related genesPredicted membrane proteins
Protein Function
Cancer-related genes:Mutated cancer genes
Transmembrane
4394..4414; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Mucin 17, cell surface associated
Chromosome
7
Position
101020072-101058859
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
Cancer-related genes:Mutated cancer genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-5621480 dectin 2 family
- R-hsa-5083632 defective c1galt1c1 causes tnps
- R-hsa-5083625 defective galnt3 causes hftc
- R-hsa-3906995 diseases associated with o glycosylation of proteins
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-168249 innate immune system
- R-hsa-5173105 o linked glycosylation
- R-hsa-913709 o linked glycosylation of mucins
- R-hsa-597592 post translational protein modification
- R-hsa-977068 termination of o glycan biosynthesis
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | Yes | No |
| ecm | ecm | GO_Intercell | Yes | No | Yes | Yes | No |
| ecm | ecm | CellCellInteractions | Yes | No | Yes | Yes | No |
| ecm | ecm | OmniPath | Yes | No | Yes | Yes | No |
| extracellular | extracellular | DGIdb | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
4,493
Mass
451,741
Sequence
MPRPGTMALCLLTLVLSLLPPQAAAEQDLSVNRAVWDGGGCISQGDVLNRQCQQLSQHVRTGSAANTATGTTSTNVVEPRMYLSCSTNPEMTSIESSVTSDTPGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLPTSFPGASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGSTPGTTIFIPSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTITSHTIPPTFPPAHSSTPPTTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPRTTTCFGDGCQNTASRCKNGGTWDGLKCQCPNLYYGELCEEVVSSIDIGPPETISAQMELTVTVTSVKFTEELKNHSSQEFQEFKQTFTEQMNIVYSGIPEYVGVNITKLRLGSVVVEHDVLLRTKYTPEYKTVLDNATEVVKEKITKVTTQQIMINDICSDMMCFNTTGTQVQNITVTQYDPEEDCRKMAKEYGDYFVVEYRDQKPYCISPCEPGFSVSKNCNLGKCQMSLSGPQCLCVTTETHWYSGETCNQGTQKSLVYGLVGAGVVLMLIILVALLMLVFRSKREVKRQKYRLSQLYKWQEEDSGPAPGTFQNIGFDICQDDDSIHLESIYSNFQPSLRHIDPETKIRIQRPQVMTTSF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Major, Mb-MUC17; IsoId=Q685J3-1; Sequence=Displayed; Name=2; Synonyms=Minor, s-MUC17; IsoId=Q685J3-2; Sequence=VSP_032648, VSP_032649
Alternative Sequence
4241..4262; RLGSVVVEHDVLLRTKYTPEYK -> HDVFQHHWHPSAKHYGDPVRP (in isoform 2); 4363..4493; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
88..105; Polar residues; 106..146; Low complexity; 148..159; Polar residues; 188..210; Low complexity; 211..223; Polar residues; 308..323; Low complexity; 324..344; Polar residues; 425..441; Low complexity; 442..483; Polar residues; 484..497; Low complexity; 498..528; Polar residues; 529..573; Low complexity; 584..618; Low complexity; 619..629; Polar residues; 644..660; Polar residues; 661..677; Low complexity; 678..705; Polar residues; 706..733; Low complexity; 737..754; Polar residues; 755..776; Low complexity; 777..832; Polar residues; 833..849; Low complexity; 854..868; Polar residues; 886..900; Low complexity; 901..944; Polar residues; 945..972; Low complexity; 973..1011; Polar residues; 1012..1021; Low complexity; 1029..1062; Polar residues; 1063..1090; Low complexity; 1091..1104; Polar residues; 1116..1132; Polar residues; 1133..1149; Low complexity; 1175..1198; Polar residues; 1205..1222; Polar residues; 1237..1279; Low complexity; 1310..1320; Polar residues; 1326..1338; Polar residues; 1360..1394; Polar residues; 1395..1415; Low complexity; 1423..1442; Low complexity; 1461..1483; Polar residues; 1484..1499; Low complexity; 1504..1516; Polar residues; 1537..1547; Low complexity; 1548..1575; Polar residues; 1590..1604; Polar residues; 1605..1620; Low complexity; 1621..1673; Polar residues; 1679..1775; Polar residues; 1776..1797; Low complexity; 1798..1836; Polar residues; 1837..1852; Low complexity; 1856..1883; Polar residues; 1884..1900; Low complexity; 1901..1921; Polar residues; 1947..1976; Polar residues; 1984..2033; Low complexity; 2034..2043; Polar residues; 2051..2077; Polar residues; 2078..2091; Low complexity; 2092..2156; Polar residues; 2177..2196; Low complexity; 2197..2240; Polar residues; 2241..2268; Low complexity; 2269..2281; Polar residues; 2295..2307; Polar residues; 2308..2317; Low complexity; 2325..2358; Polar residues; 2359..2371; Low complexity; 2372..2395; Polar residues; 2396..2445; Low complexity; 2462..2499; Low complexity; 2524..2547; Polar residues; 2548..2563; Low complexity; 2564..2576; Polar residues; 2586..2617; Low complexity; 2618..2628; Polar residues; 2654..2681; Low complexity; 2682..2693; Polar residues; 2710..2740; Low complexity; 2741..2751; Polar residues; 2765..2816; Low complexity; 2829..2853; Low complexity; 2879..2900; Polar residues; 2901..2917; Low complexity; 2950..2976; Low complexity; 2988..3009; Polar residues; 3010..3031; Low complexity; 3037..3057; Polar residues; 3073..3089; Low complexity; 3104..3140; Low complexity; 3141..3166; Polar residues; 3185..3211; Low complexity; 3212..3253; Polar residues; 3254..3267; Low complexity; 3268..3288; Polar residues; 3289..3314; Low complexity; 3329..3357; Polar residues; 3358..3375; Low complexity; 3376..3401; Polar residues; 3405..3414; Low complexity; 3415..3441; Polar residues; 3447..3475; Polar residues; 3476..3501; Low complexity; 3502..3549; Polar residues; 3558..3571; Polar residues; 3589..3616; Low complexity; 3626..3635; Polar residues; 3667..3679; Low complexity; 3690..3701; Polar residues; 3785..3806; Polar residues; 3967..3988; Low complexity; 4008..4083; Low complexity; 4090..4129; Low complexity
Repeat
185..245; 1; 246..300; 2; 301..361; 3; 362..418; 4; 420..477; 5; 479..538; 6; 539..597; 7; 598..654; 8; 656..715; 9; 716..774; 10; 775..831; 11; 833..892; 12; 893..951; 13; 952..1010; 14; 1011..1069; 15; 1070..1121; 16; 1122..1187; 17; 1188..1246; 18; 1247..1305; 19; 1306..1364; 20; 1365..1423; 21; 1424..1482; 22; 1483..1541; 23; 1542..1600; 24; 1601..1656; 25; 1658..1717; 26; 1718..1776; 27; 1777..1835; 28; 1836..1895; 29; 1896..1951; 30; 1953..2012; 31; 2013..2071; 32; 2072..2127; 33; 2129..2188; 34; 2189..2247; 35; 2248..2306; 36; 2307..2365; 37; 2366..2424; 38; 2425..2483; 39; 2484..2540; 40; 2542..2601; 41; 2602..2653; 42; 2654..2719; 43; 2720..2770; 44; 2772..2837; 45; 2838..2896; 46; 2897..2955; 47; 2956..3014; 48; 3015..3073; 49; 3074..3132; 50; 3133..3191; 51; 3192..3247; 52; 3249..3308; 53; 3309..3367; 54; 3368..3426; 55; 3427..3485; 56; 3486..3544; 57; 3604..3662; 58; 3663..3727; 59
Domain (FT)
4131..4170; EGF-like; 4184..4291; SEA
Region
88..159; Disordered; 185..3727; 59 X approximate tandem repeats; 188..223; Disordered; 248..277; Disordered; 306..344; Disordered; 425..629; Disordered; 644..868; Disordered; 886..1104; Disordered; 1116..1163; Disordered; 1175..1279; Disordered; 1296..1338; Disordered; 1360..1516; Disordered; 1537..1575; Disordered; 1590..1930; Disordered; 1947..2163; Disordered; 2177..2281; Disordered; 2295..2501; Disordered; 2524..2630; Disordered; 2647..2693; Disordered; 2709..2751; Disordered; 2765..2853; Disordered; 2879..2925; Disordered; 2942..3167; Disordered; 3182..3577; Disordered; 3589..3635; Disordered; 3667..3701; Disordered; 3785..3812; Disordered; 3829..3849; Disordered; 3892..3914; Disordered; 3965..3988; Disordered; 4008..4129; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 1