Protein detail

LMBD2

G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2)

Entry name LMBD2	UniProt ID Q68DH5	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 9	Protein classification Disease related genesPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2)

Protein Class (4)

Disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (3)

Disease related genes
Transporters
Potential drug targets

Transmembrane

6..21; Helical; 33..53; Helical; 106..126; Helical; 151..171; Helical; 187..207; Helical; 388..408; Helical; 433..453; Helical; 474..494; Helical; 522..542; Helical

Transmembrane Count

Ensembl

ENSG00000164187

Entrez Gene Symbol

LMBRD2

Gene Synonym

DKFZp434H2226

Gene Description

LMBR1 domain containing 2

Chromosome

Position

36098407-36151887

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway4

Protein Function (3)

Disease related genes
Transporters
Potential drug targets

Cellular Component (2)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence13

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Western blottingFlow cytometryMORPH	3	32795414 38731868 41216884

Sequence, Structure & Domains8

Sequences

Length

695

Mass

81,172

Sequence

MSGAALGLEIVFVFFLALFLLHRYGDFKKQHRLVIIGTLLAWYLCFLIVFILPLDVSTTIYNRCKHAAANSSPPENSNITGLYATANPVPSQHPCFKPWSYIPDGIMPIFWRVVYWTSQFLTWILLPFMQSYARSGGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPHLHLEWNQLQTIGIAAANTWGLFLLVLLLGYGLVEIPRSYWNGAKRGYLLMKTYFKAAKLMTEKADAEENLEDAMEEVRKVNESIKYNHPLRKCVDTILKKCPTEYQEKMGRNMDDYEDFDEKHSIYPSEKSLVKLHKQVIYSVQRHRRTQVQWQILLEQAFYLEDVAKNETSATHQFVHTFQSPEPENRFIQYFYNPTFEWYWECLLRPWFYKILAVVLSIFSVIVVWSECTFFSTTPVLSLFAVFIQLAEKTYNYIYIEIACFLSIFFLSICVYSTVFRIRVFNYYYLASHHQTDAYSLLFSGMLFCRLTPPLCLNFLGLTHMDSSISHKNTQPTAYTSIMGSMKVLSFIADGFYIYYPMLVVILCIATYFSLGTRCLNLLGFQQFMGDDDMTSDLVNEGKELIRKEKRKRQRQEEGENRRREWKERYGHNREDSTRNRNIHTDPKESNFSDVNTNRSAFKYTRANNRTERDRIELLQDAEPLDFNAETFTDDPLESESGRYQPGGRYLSMSRSDIFNDV

Domain & Motif Annotations

Compositional Bias

588..624; Basic and acidic residues

Coiled Coil

227..262; 571..603

Region

581..628; Disordered; 662..682; Disordered

Protein Families

LIMR family

Sequence Similarities

Belongs to the LIMR family.

Clinical Relevance2

Disease Involvement (2)

Disease variantIntellectual disability

Antibody

HPA012165

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available