Protein detail

LMBD2

G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2)

Protein symbol LMBD2	UniProt ID Q68DH5	EVMP score 0.25
Frequency 2	Transmembrane count 9	Protein classification Disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Basic Information

Protein Names

G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2)

Protein Class

Disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function

Disease related genes
Transporters
Potential drug targets

Transmembrane

6..21; Helical; 33..53; Helical; 106..126; Helical; 151..171; Helical; 187..207; Helical; 388..408; Helical; 433..453; Helical; 474..494; Helical; 522..542; Helical

Transmembrane Count

Ensembl

ENSG00000164187

Entrez Gene Symbol

LMBRD2

Gene Synonym

DKFZp434H2226

Gene Description

LMBR1 domain containing 2

Chromosome

Position

36098407-36151887

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Disease related genes
Transporters
Potential drug targets

Cellular Component

Biological Process

Mediation Categories

Receptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Western blottingFlow cytometryMORPH	3	32795414 38731868 41216884

Sequence, Structure & Domains

Sequences

Length

695

Mass

81,172

Sequence

MSGAALGLEIVFVFFLALFLLHRYGDFKKQHRLVIIGTLLAWYLCFLIVFILPLDVSTTIYNRCKHAAANSSPPENSNITGLYATANPVPSQHPCFKPWSYIPDGIMPIFWRVVYWTSQFLTWILLPFMQSYARSGGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPHLHLEWNQLQTIGIAAANTWGLFLLVLLLGYGLVEIPRSYWNGAKRGYLLMKTYFKAAKLMTEKADAEENLEDAMEEVRKVNESIKYNHPLRKCVDTILKKCPTEYQEKMGRNMDDYEDFDEKHSIYPSEKSLVKLHKQVIYSVQRHRRTQVQWQILLEQAFYLEDVAKNETSATHQFVHTFQSPEPENRFIQYFYNPTFEWYWECLLRPWFYKILAVVLSIFSVIVVWSECTFFSTTPVLSLFAVFIQLAEKTYNYIYIEIACFLSIFFLSICVYSTVFRIRVFNYYYLASHHQTDAYSLLFSGMLFCRLTPPLCLNFLGLTHMDSSISHKNTQPTAYTSIMGSMKVLSFIADGFYIYYPMLVVILCIATYFSLGTRCLNLLGFQQFMGDDDMTSDLVNEGKELIRKEKRKRQRQEEGENRRREWKERYGHNREDSTRNRNIHTDPKESNFSDVNTNRSAFKYTRANNRTERDRIELLQDAEPLDFNAETFTDDPLESESGRYQPGGRYLSMSRSDIFNDV

3D Structural Models

Domain & Motif Annotations

Compositional Bias

588..624; Basic and acidic residues

Coiled Coil

227..262; 571..603

Region

581..628; Disordered; 662..682; Disordered

Protein Families

LIMR family

Sequence Similarities

Belongs to the LIMR family.

Clinical Relevance

Disease Involvement

Disease variantIntellectual disability

Antibody

HPA012165