Protein detail

RHG17

Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)

Entry name RHG17	UniProt ID Q68EM7	EVMP confidence score 0.72
Supporting publications (n) 15	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000140750

Entrez Gene Symbol

ARHGAP17

Gene Synonym (5)

FLJ10308FLJ13219NADRINRICH1WBP15

Gene Description

Rho GTPase activating protein 17

Chromosome

Position

24919389-25015666

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization5

Tissue SpecificepididymisCell SpecificEarly spermatidsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway8

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04530 Tight junction

Reactome (8)

Canonical Pathways (3)

M5193 Sig chemotaxis
M68 Pid rhoa reg pathway
M281 Pid fak pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence14

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ARHGAP17	PRKACA	P17612	S	702	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No

Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KAPCA	P17612	RHG17	Q68EM7	Yes	No	Yes	iPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:26507661 SIGNOR:26507661
CIP4	Q15642	RHG17	Q68EM7	Yes	No	Yes	SIGNORHPRDHINTHuRILit-BM-17	Lit-BM-17:11431473 HPRD:11431473 HINT:11431473 SIGNOR:26507661
RHG17	Q68EM7	RAC1	P63000	Yes	Yes	Yes	WangSIGNOR	SIGNOR:26507661

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARHGAP17 OPA1	O60313 Q68EM7	0:0	hu.MAP
	ARHGAP17 SH3BP1	Q68EM7 Q9Y3L3	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	2	40222457 36114323

Sequence, Structure & Domains10

Sequences

Length

881

Mass

95,437

Sequence

MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGTDAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q68EM7-1; Sequence=Displayed; Name=2; IsoId=Q68EM7-2; Sequence=VSP_023687; Name=3; IsoId=Q68EM7-3; Sequence=VSP_023683; Name=4; Synonyms=RICH1B; IsoId=Q68EM7-4; Sequence=VSP_023684, VSP_023685; Name=5; IsoId=Q68EM7-5; Sequence=VSP_023688; Name=6; IsoId=Q68EM7-6; Sequence=VSP_023689; Name=7; IsoId=Q68EM7-7; Sequence=VSP_023682, VSP_023686

Alternative Sequence

1..467; Missing (in isoform 7); 1..273; Missing (in isoform 3); 215..226; LLEAQADYHRKA -> ISGRKNQPLGLP (in isoform 4); 227..881; Missing (in isoform 4); 468..496; TGNDSDSGTLERKRPASMAVMEGDLVKKE -> MCGFNTCGPMGFCLSSLLAWCVDCFFSLC (in isoform 7); 497..574; Missing (in isoform 2); 839..881; DSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL -> GFQNRIAASFLKCTQTQPAKTCLAASCWI (in isoform 5); 840..881; SNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL -> V (in isoform 6)

Domain & Motif Annotations

Compositional Bias

459..475; Polar residues; 592..617; Polar residues; 637..650; Pro residues; 653..664; Low complexity; 665..678; Pro residues; 679..698; Low complexity; 712..721; Pro residues; 752..764; Pro residues; 806..816; Pro residues; 822..844; Polar residues; 845..865; Basic and acidic residues; 872..881; Acidic residues

Motif

753..766; SH3-binding

Domain (CC)

The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions.

Domain (FT)

14..246; BAR; 252..442; Rho-GAP

Region

459..482; Disordered; 511..881; Disordered

Clinical Relevance4

Antibody (2)

HPA041703 HPA075891

Interaction Protein (6)

ENSG00000006740ENSG00000077549ENSG00000100092ENSG00000124507ENSG00000125733ENSG00000126016

Interaction Count

Interaction Dataset (4)

biogrid_opencell_bioplexbiogrid_opencellintact_biogrid_opencellintact_biogrid

Supporting Publications15

PMID	Title	Abstract
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
34064677	Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.	No abstract available
35359923	TMT-Based Quantitative Proteomics Analysis of Synovial Fluid-Derived Exosomes in Inflammatory Arthritis.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
36497184	Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.	No abstract available
37563857	Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available

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