Protein detail

RHG17

Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)

Protein symbol RHG17	UniProt ID Q68EM7	EVMP score 0.72
Frequency 15	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000140750

Entrez Gene Symbol

ARHGAP17

Gene Synonym

FLJ10308FLJ13219NADRINRICH1WBP15

Gene Description

Rho GTPase activating protein 17

Chromosome

Position

24919389-25015666

Frequency

EVMP Score

0.72

Fluorescence & Localization

Tissue SpecificepididymisCell SpecificEarly spermatidsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04530 Tight junction

Reactome

Canonical Pathways

M5193 Sig chemotaxis
M68 Pid rhoa reg pathway
M281 Pid fak pathway

Mediation Categories

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ARHGAP17	PRKACA	P17612	S	702	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No

Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KAPCA	P17612	RHG17	Q68EM7	Yes	No	Yes	iPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:26507661 SIGNOR:26507661
CIP4	Q15642	RHG17	Q68EM7	Yes	No	Yes	SIGNORHPRDHINTHuRILit-BM-17	Lit-BM-17:11431473 HPRD:11431473 HINT:11431473 SIGNOR:26507661
RHG17	Q68EM7	RAC1	P63000	Yes	Yes	Yes	WangSIGNOR	SIGNOR:26507661

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARHGAP17 OPA1	O60313 Q68EM7	0:0	hu.MAP
	ARHGAP17 SH3BP1	Q68EM7 Q9Y3L3	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	2	40222457 36114323

Sequence, Structure & Domains

Sequences

Length

881

Mass

95,437

Sequence

MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGTDAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q68EM7-1; Sequence=Displayed; Name=2; IsoId=Q68EM7-2; Sequence=VSP_023687; Name=3; IsoId=Q68EM7-3; Sequence=VSP_023683; Name=4; Synonyms=RICH1B; IsoId=Q68EM7-4; Sequence=VSP_023684, VSP_023685; Name=5; IsoId=Q68EM7-5; Sequence=VSP_023688; Name=6; IsoId=Q68EM7-6; Sequence=VSP_023689; Name=7; IsoId=Q68EM7-7; Sequence=VSP_023682, VSP_023686

Alternative Sequence

1..467; Missing (in isoform 7); 1..273; Missing (in isoform 3); 215..226; LLEAQADYHRKA -> ISGRKNQPLGLP (in isoform 4); 227..881; Missing (in isoform 4); 468..496; TGNDSDSGTLERKRPASMAVMEGDLVKKE -> MCGFNTCGPMGFCLSSLLAWCVDCFFSLC (in isoform 7); 497..574; Missing (in isoform 2); 839..881; DSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL -> GFQNRIAASFLKCTQTQPAKTCLAASCWI (in isoform 5); 840..881; SNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL -> V (in isoform 6)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

459..475; Polar residues; 592..617; Polar residues; 637..650; Pro residues; 653..664; Low complexity; 665..678; Pro residues; 679..698; Low complexity; 712..721; Pro residues; 752..764; Pro residues; 806..816; Pro residues; 822..844; Polar residues; 845..865; Basic and acidic residues; 872..881; Acidic residues

Motif

753..766; SH3-binding

Domain (CC)

The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions.

Domain (FT)

14..246; BAR; 252..442; Rho-GAP

Region

459..482; Disordered; 511..881; Disordered

Clinical Relevance

Antibody

HPA041703 HPA075891

Interaction Protein

ENSG00000006740ENSG00000077549ENSG00000100092ENSG00000124507ENSG00000125733ENSG00000126016

Interaction Count

Interaction Dataset

biogrid_opencell_bioplexbiogrid_opencellintact_biogrid_opencellintact_biogrid