Protein detail
S6A19
Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)
Entry name S6A19 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
- Human disease related genes:Urinary system diseases:Kidney diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Transmembrane
42..62; Helical; Name=1; 68..88; Helical; Name=2; 121..141; Helical; Name=3; 193..213; Helical; Name=4; 222..242; Helical; Name=5; 269..289; Helical; Name=6; 305..325; Helical; Name=7; 414..434; Helical; Name=8; 457..477; Helical; Name=9; 491..511; Helical; Name=10; 532..552; Helical; Name=11; 582..602; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
B0AT1
Gene Description
Solute carrier family 6 member 19
Chromosome
5
Position
1201595-1225111
EVMP confidence score
0.38
Function & Pathway7
Protein Function (5)
- Human disease related genes:Urinary system diseases:Kidney diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
Reactome (6)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence25
Ligand-Receptor Signaling (23)
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellTalkDB | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc6 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
Sequence, Structure & Domains9
Sequences
Length
634
Mass
71,110
Sequence
MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
3D Structural Models
Turn
12..14; 25..27; 29..31; 65..70; 109..112; 177..180; 216..218; 346..349; 372..376; 399..402; 411..414; 445..447; 507..510
Helix
21..24; 38..48; 58..64; 71..80; 82..96; 101..104; 113..141; 149..151; 164..168; 173..176; 196..211; 219..241; 251..255; 259..263; 266..278; 285..290; 301..316; 318..345; 352..354; 360..370; 403..407; 415..429; 431..444; 455..469; 470..473; 478..506; 511..521; 528..535; 537..545; 547..553; 582..608
Beta Strand
9..11; 18..20; 49..57; 144..147; 157..162; 185..188; 212..215; 244..246; 248..250; 282..284; 357..359; 387..391; 395..398; 451..453; 554..556; 559..562; 567..569; 574..577
3D Structure
Electron microscopy (9)
Domain & Motif Annotations
Protein Families (2)
- Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
- SLC6A19 subfamily
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.