Protein detail

S6A19

Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)

Protein symbol S6A19	UniProt ID Q695T7	EVMP score 0.38
Frequency	Transmembrane count 12	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)

Protein Class

Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function

Human disease related genes:Urinary system diseases:Kidney diseases
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Transmembrane

42..62; Helical; Name=1; 68..88; Helical; Name=2; 121..141; Helical; Name=3; 193..213; Helical; Name=4; 222..242; Helical; Name=5; 269..289; Helical; Name=6; 305..325; Helical; Name=7; 414..434; Helical; Name=8; 457..477; Helical; Name=9; 491..511; Helical; Name=10; 532..552; Helical; Name=11; 582..602; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000174358

Entrez Gene Symbol

SLC6A19

Gene Synonym

B0AT1

Gene Description

Solute carrier family 6 member 19

Chromosome

Position

1201595-1225111

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

Human disease related genes:Urinary system diseases:Kidney diseases
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
B(0)AT1-Collectrin heteromeric amino acid transporter complex	CLTRN SLC6A19	Q695T7 Q9HBJ8	1:1	ComplexPortal		36830670 14755292 34880232 26240152

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	11	32795414 39290459 39949490 38871730 38731868 30071318 37686366 40098346 31320591 36982312 40091455

Sequence, Structure & Domains

Sequences

Length

634

Mass

71,110

Sequence

MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY

3D Structural Models

Turn

12..14; 25..27; 29..31; 65..70; 109..112; 177..180; 216..218; 346..349; 372..376; 399..402; 411..414; 445..447; 507..510

Helix

21..24; 38..48; 58..64; 71..80; 82..96; 101..104; 113..141; 149..151; 164..168; 173..176; 196..211; 219..241; 251..255; 259..263; 266..278; 285..290; 301..316; 318..345; 352..354; 360..370; 403..407; 415..429; 431..444; 455..469; 470..473; 478..506; 511..521; 528..535; 537..545; 547..553; 582..608

Beta Strand

9..11; 18..20; 49..57; 144..147; 157..162; 185..188; 212..215; 244..246; 248..250; 282..284; 357..359; 387..391; 395..398; 451..453; 554..556; 559..562; 567..569; 574..577

3D Structure

Electron microscopy (9)

Domain & Motif Annotations

Protein Families

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
SLC6A19 subfamily

Sequence Similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.

Clinical Relevance

Disease Involvement

Disease variant

Antibody

HPA037415 HPA043207

Interaction Protein

ENSG00000130234

Interaction Count

Interaction Dataset

intact_biogrid