Protein detail
FCRLB
Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY)
Entry name FCRLB | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY)
Protein Function
CD markers
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization6
Brain Regional Specificchoroid plexusCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificintermediate monocyteBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function
CD markers
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
Canonical Pathways (3)
- M247 Pid insulin glucose pathway
- M249 Pid pi3kci akt pathway
- M67 Pid arf6 trafficking pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence33
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MARH9 | Q86YJ5 | FCRL2 | Q96LA5 | Yes | No | Yes | SIGNOR | SIGNOR:19457934 |
Sequence, Structure & Domains8
Sequences
Length
426
Mass
46,904
Sequence
MWPLTALLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLWYLGHLLLPSHKKSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIPVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDPASTTAPAPWAAALAPGNRPLSFRKPPVSRSVPLVTSVRNTTSTGLQFPASGAPTAGPPACAPPTPLEQSAGALKPDVDLLLREMQLLKGLLSRVVLELKEPQALRELRGTPETPTSHFAVSPGTPETTPVES
Alternative Products
Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q6BAA4-1; Sequence=Displayed; Name=2; Synonyms=FCRL2c1; IsoId=Q6BAA4-2; Sequence=VSP_033421, VSP_033422; Name=3; Synonyms=FCRL2c2; IsoId=Q6BAA4-3; Sequence=VSP_033419, VSP_033421, VSP_033422; Name=4; Synonyms=FCRL2b1; IsoId=Q6BAA4-4; Sequence=VSP_033420, VSP_033423; Name=5; Synonyms=FCRL2b2; IsoId=Q6BAA4-5; Sequence=VSP_033419, VSP_033420, VSP_033423
Alternative Sequence
11..17; Missing (in isoform 3 and isoform 5); 192..318; ELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDPASTTAPAPWAAALAPGNRPLSFRK -> AARCAASTGAPSTQSRSPRSRSSNRTGARRLPPPAVSGNAVRGCSSRGRVLPWTRPPPPPQLHGPQPWLLVIGRFPSESPRCPDRSRWSPPSGTPPPPGCSSRRAAPRLRGHPPALRRRPWNNRLEP (in isoform 4 and isoform 5); 193..275; LFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRS -> ARHAAAVRVLQVQPRGAPLRLGRRVHSPGARGRGARIVLVRGGYRHPQCPETQSVAAAPGAGFSPGPGLHHRPSSMGRSLGSW (in isoform 2 and isoform 3); 276..426; Missing (in isoform 2 and isoform 3); 319..426; Missing (in isoform 4 and isoform 5)
Domain & Motif Annotations
Compositional Bias
406..426; Polar residues
Domain (FT)
23..101; Ig-like C2-type 1; 103..189; Ig-like C2-type 2
Region
400..426; Disordered