Protein detail

FCRLB

Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY)

Protein symbol FCRLB	UniProt ID Q6BAA4	EVMP score 0.25
Frequency 2	Transmembrane count	Protein classification

Basic Information

Protein Names

Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY)

Protein Function

CD markers

Ensembl

ENSG00000132704

Entrez Gene Symbol

FCRL2

Frequency

EVMP Score

0.25

Fluorescence & Localization

Brain Regional Specificchoroid plexusCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificintermediate monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

CD markers

Cellular Component

Molecular Function

Biological Process

Canonical Pathways

M247 Pid insulin glucose pathway
M249 Pid pi3kci akt pathway
M67 Pid arf6 trafficking pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

31 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MARH9	Q86YJ5	FCRL2	Q96LA5	Yes	No	Yes	SIGNOR	SIGNOR:19457934

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；Western blotting；ELISA；RNA Sequencing；Flow cytometry	2	41068253 41307968

Sequence, Structure & Domains

Sequences

Length

426

Mass

46,904

Sequence

MWPLTALLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLWYLGHLLLPSHKKSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIPVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDPASTTAPAPWAAALAPGNRPLSFRKPPVSRSVPLVTSVRNTTSTGLQFPASGAPTAGPPACAPPTPLEQSAGALKPDVDLLLREMQLLKGLLSRVVLELKEPQALRELRGTPETPTSHFAVSPGTPETTPVES

Alternative Products

Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q6BAA4-1; Sequence=Displayed; Name=2; Synonyms=FCRL2c1; IsoId=Q6BAA4-2; Sequence=VSP_033421, VSP_033422; Name=3; Synonyms=FCRL2c2; IsoId=Q6BAA4-3; Sequence=VSP_033419, VSP_033421, VSP_033422; Name=4; Synonyms=FCRL2b1; IsoId=Q6BAA4-4; Sequence=VSP_033420, VSP_033423; Name=5; Synonyms=FCRL2b2; IsoId=Q6BAA4-5; Sequence=VSP_033419, VSP_033420, VSP_033423

Alternative Sequence

11..17; Missing (in isoform 3 and isoform 5); 192..318; ELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDPASTTAPAPWAAALAPGNRPLSFRK -> AARCAASTGAPSTQSRSPRSRSSNRTGARRLPPPAVSGNAVRGCSSRGRVLPWTRPPPPPQLHGPQPWLLVIGRFPSESPRCPDRSRWSPPSGTPPPPGCSSRRAAPRLRGHPPALRRRPWNNRLEP (in isoform 4 and isoform 5); 193..275; LFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRS -> ARHAAAVRVLQVQPRGAPLRLGRRVHSPGARGRGARIVLVRGGYRHPQCPETQSVAAAPGAGFSPGPGLHHRPSSMGRSLGSW (in isoform 2 and isoform 3); 276..426; Missing (in isoform 2 and isoform 3); 319..426; Missing (in isoform 4 and isoform 5)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

406..426; Polar residues

Domain (FT)

23..101; Ig-like C2-type 1; 103..189; Ig-like C2-type 2

Region

400..426; Disordered

Clinical Relevance