Protein detail
FCRL6
Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)
Entry name FCRL6 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)
Protein Function
Predicted intracellular proteins
Transmembrane
308..328; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (5)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence33
Ligand-Receptor Signaling (32)
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | Yes | Yes | |||
| receptor | receptor | Surfaceome | Yes | Yes | |||
| fc | receptor | Almen2009 | Yes | Yes | |||
| ig_like | receptor | Almen2009 | Yes | Yes | |||
| fcr | receptor | Surfaceome | Yes | Yes | |||
| ig | receptor | Surfaceome | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | DGIdb | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes |
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Sequence, Structure & Domains
Sequences
Length
434
Mass
47,748
Sequence
MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=FCRL6v1; IsoId=Q6DN72-1; Sequence=Displayed; Name=2; IsoId=Q6DN72-2; Sequence=VSP_023565, VSP_023568, VSP_023570; Name=3; Synonyms=FCRL6v4; IsoId=Q6DN72-3; Sequence=VSP_023567, VSP_023569; Name=4; IsoId=Q6DN72-4; Sequence=VSP_023566, VSP_023568, VSP_023570
Alternative Sequence
1; M -> MLPSLGPM (in isoform 2); 105..199; Missing (in isoform 4); 383..397; ARSAEFTVGRKDSSI -> GQFYHLCGGEMPAAQ (in isoform 3); 394..406; DSSIICAEVRCLQ -> FYHLCGGEMPAAQ (in isoform 2 and isoform 4); 398..434; Missing (in isoform 3); 407..434; Missing (in isoform 2 and isoform 4)
Domain & Motif Annotations
Motif
369..374; ITIM motif
Domain (CC)
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
Domain (FT)
20..95; Ig-like C2-type 1; 111..197; Ig-like C2-type 2; 207..293; Ig-like C2-type 3
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 33304478 | The proteomic landscape of small urinary extracellular vesicles during kidney transplantation. | No related sentences available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |