Protein detail

LAIR1

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)

Entry name LAIR1	UniProt ID Q6GTX8	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)

Protein Class

CD markersPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins

Transmembrane

166..186; Helical

Transmembrane Count

Ensembl

ENSG00000167613

Entrez Gene Symbol

LAIR1

Gene Synonym

CD305LAIR-1

Gene Description

Leukocyte associated immunoglobulin like receptor 1

Chromosome

Position

54351384-54370558

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

Reactome

Canonical Pathways

M206 Pid pdgfra pathway
M166 Pid atf2 pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LAIR1	LYN	P07948	Y	281	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	FAM47A LAIR1	Q5JRC9 Q6GTX8	0:0	hu.MAP2
	LAIR1	Q6GTX8	3	PDB	PDB:3kgrPDB:3rp1

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	4	38014595 27487081 37223008 36982312

Sequence, Structure & Domains

Sequences

Length

287

Mass

31,469

Sequence

MSPHPTALLGLVLCLAQTIHTQEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHLYILIGVSVVFLFCLLLLVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSALAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARH

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=LAIR-1a; IsoId=Q6GTX8-1; Sequence=Displayed; Name=2; Synonyms=LAIR-1b; IsoId=Q6GTX8-2; Sequence=VSP_020711; Name=3; Synonyms=LAIR-1c; IsoId=Q6GTX8-3; Sequence=VSP_020710, VSP_020711; Name=4; Synonyms=LAIR-1d; IsoId=Q6GTX8-4; Sequence=VSP_020712

Alternative Sequence

23; Missing (in isoform 3); 122..138; Missing (in isoform 2 and isoform 3); 210..287; Missing (in isoform 4)

3D Structural Models

Helix

63..65; 93..95

Beta Strand

30..35; 37..40; 45..51; 57..62; 67..71; 75..78; 81..90; 97..105; 116..121

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

134..145; Polar residues; 198..208; Basic and acidic residues

Motif

249..254; ITIM motif 1; 279..284; ITIM motif 2

Domain (CC)

ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation.

Domain (FT)

29..117; Ig-like C2-type

Region

121..155; Disordered; 192..211; Disordered

Clinical Relevance

Related Diseases

Solid tumour/cancer

Biomarker

Phase 1/2

Antibody

HPA011155

Interaction Protein

ENSG00000111679

Interaction Count

Interaction Dataset

intact_biogrid