Protein detail

PEXRP

Peroxisomal reductase activating PPAR-gamma (PexRAP) (EC 1.1.1.101) (Dehydrogenase/reductase SDR family member 7B) (Short-chain dehydrogenase/reductase family 32C member 1) (Protein SDR32C1)

Entry name PEXRP	UniProt ID Q6IAN0	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Peroxisomal reductase activating PPAR-gamma (PexRAP) (EC 1.1.1.101) (Dehydrogenase/reductase SDR family member 7B) (Short-chain dehydrogenase/reductase family 32C member 1) (Protein SDR32C1)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

18..38; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000109016

Entrez Gene Symbol

DHRS7B

Gene Synonym (4)

CGI-93DKFZp566O084MGC8916SDR32C1

Gene Description

Dehydrogenase/reductase 7B

Chromosome

Position

21123364-21193265

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificLate spermatids

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (4)

Biological Process (3)

Reactome (2)

Canonical Pathways (3)

M72 Pid nectin pathway
M156 Pid ecadherin nascent aj pathway
M232 Pid ecadherin stabilization pathway

Mediation Categories (2)

Immune mediationMetabolism mediation

Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ACIN1 ARMCX3 ATP7A BET1 CSGALNACT1 DHRS7B SNAP91	O15155 O60641 Q04656 Q6IAN0 Q8TDX6 Q9UH62 Q9UKV3	0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_534

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryR Sequencing	1	27605433

Sequence, Structure & Domains6

Sequences

Length

325

Mass

35,119

Sequence

MVSPATRKSLPKVKAMDFITSTAILPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMASRARKERKSKNS

Domain & Motif Annotations

Motif

255..287; Nuclear localization signal

Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Sequence Similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Clinical Relevance4

Antibody (2)

HPA012132 HPA016873

Interaction Protein

ENSG00000106688

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
40222457	Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement.	No abstract available