Protein detail

TWF2

Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein)

Entry name TWF2	UniProt ID Q6IBS0	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000247596

Entrez Gene Symbol

TWF2

Gene Synonym (3)

A6rA6RPPTK9L

Gene Description

Twinfilin actin binding protein 2

Chromosome

Position

52228612-52246788

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization6

Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificdeep-layer near-projectingBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (9)

Molecular Function (8)

Biological Process (3)

Reactome (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence14

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
PPM1B PPP1R14C TWF2 UBL7	O75688 Q6IBS0 Q8TAE6 Q96S82	0:0:0:0	Havugimana2012	Havugimana2012:C_322
CAPZA2 CAPZA3 CAPZB DHFR INPP5E TWF2 UBC	P00374 P0CG48 P47755 P47756 Q6IBS0 Q96KX2 Q9NRR6	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9142
CAPZA1 CAPZB DHFR INPP5E TWF2 UBC	P00374 P0CG48 P47756 P52907 Q6IBS0 Q9NRR6	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5100
CDC37 CDK11B CDK4 CDK7 STK35 TWF2	P11802 P21127 P50613 Q16543 Q6IBS0 Q8TDR2	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7903
ACTB CAPZA1 CAPZB MAP1B NEB PPP2R2B TWF2	P20929 P46821 P47756 P52907 P60709 Q00005 Q6IBS0	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5431
CSNK1G3 FDXR PTK2 TWF2	P22570 Q05397 Q6IBS0 Q9Y6M4	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	38037300 40689422

Sequence, Structure & Domains12

Sequences

Length

349

Mass

39,548

Sequence

MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS

3D Structural Models

Turn

207..210

Helix

11..22; 49..57; 58..60; 95..112; 114..116; 126..129; 131..136; 184..194; 222..228; 261..263; 266..285; 300..302; 305..312

Beta Strand

26..33; 36..43; 67..77; 80..88; 117..125; 199..206; 211..216; 231..233; 235..245; 248..258; 291..298

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

330..339; Basic residues

Domain (FT)

4..139; ADF-H 1; 177..313; ADF-H 2

Region

322..349; Disordered

Protein Families (2)

Actin-binding proteins ADF family
Twinfilin subfamily

Sequence Similarities

Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.

Clinical Relevance4

Antibody

HPA053874

Interaction Protein (4)

ENSG00000075624ENSG00000077549ENSG00000159251ENSG00000198898

Interaction Count

Interaction Dataset (2)

biogrid_bioplexintact_biogrid

Supporting Publications3

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available
39408670	Proteomic Characterization of Corneal Epithelial and Stromal Cell-Derived Extracellular Vesicles.	No abstract available
40689422	Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.	No abstract available