Protein detail

TIGD7

Tigger transposable element-derived protein 7

Entry name TIGD7	UniProt ID Q6NT04	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Tigger transposable element-derived protein 7

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000140993

Entrez Gene Symbol

TIGD7

Gene Synonym

Sancho

Gene Description

Tigger transposable element derived 7

Chromosome

Position

3298808-3305729

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005634 nucleus

Molecular Function (2)

Biological Process (3)

Canonical Pathways (2)

M14 Pid aurora b pathway
M164 Pid erbb1 downstream pathway

Mediation Categories

Other mediation

Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	6	38225453 26801919 28242843 33709510 41201090 31320591

Sequence, Structure & Domains10

Sequences

Length

549

Mass

63,236

Sequence

MNKRGKYTTLNLEEKMKVLSRIEAGRSLKSVMDEFGISKSTFYDIKKNKKLILDFVLKQDMPLVGAEKRKRTTGAKYGDVDDAVYMWYQQKRSAGVPVRGVELQAAAERFARCFGRTDFKASTGWLFRFRNRHAIGNRKGCGEQVLSSVSENVEPFRQKLSMIIKEEKLCLAQLYSGDETDLFWKSMPENSQASRKDICLPGKKINKERLSAFLCANADGTHKLKSIIIGKSKLPKSVKEDTSTLPVIYKPSKDVWFTRELFSEWFFQNFVPEVRHFQLNVLRFHDEDVRALLLLDSCPAHPSSESLTSEDGRIKCMFFPHNTSTLIQPMNQGVILSCKRLYRWKQLEESLVIFEESDDEQEKGDKGVSKIKIYNIKSAIFNWAKSWEEVKQITIANAWENLLYKKEPEYDFQGLEHGDYREILEKCGELETKLDDDRVWLNGDEEKGCLLKTKGGITKEVVQKGGEAEKQTAEFKLSAVRESLDYLLDFVDATPEFQRFHFTLKEMQQEIVKKQFQSKIHSRIGSFLKPRPHNIKDSFSGPSTSGSNH

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NT04-1; Sequence=Displayed; Name=2; IsoId=Q6NT04-2; Sequence=VSP_022453

Alternative Sequence

505..549; KEMQQEIVKKQFQSKIHSRIGSFLKPRPHNIKDSFSGPSTSGSNH -> CEFSDDS (in isoform 2)

Domain & Motif Annotations

Compositional Bias

540..549; Polar residues

Domain (FT)

1..52; HTH psq-type; 68..139; HTH CENPB-type; 169..399; DDE-1

Region

527..549; Disordered

Protein Families

Tigger transposable element derived protein family

Sequence Similarities

Belongs to the tigger transposable element derived protein family.

Clinical Relevance1

Antibody (2)

HPA041357 HPA041474

Supporting Publications1

PMID	Title	Abstract
37968711	Human umbilical cord mesenchymal stem cell-derived exosomes promote microcirculation in aged diabetic mice by TGF-β1 signaling pathway.	The mechanism may be associated with exosomes rich in TGF-β1, which is likely to promote endothelial cell proliferation and improve permeability through binding to the endothelial CD105/TβR-II receptor complex, while promoting angiogenesis and protecting skeletal muscle cells from apoptosis. Therefore, this study verified the changes of CD105 in the exosome group, and it was used as the mechanism study of this study. Western blot analysis showed that the expression of CD105 protein in lower limb muscle tissue of exosome group was significantly increased compared with that of PBS group. Western blot showed positive expression of specific proteins CD9, CD81 and TSG101 on exosomes.2.