Protein detail
MRNIP
MRN complex-interacting protein (MRN-interacting protein)
Entry name MRNIP | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
MRN complex-interacting protein (MRN-interacting protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
C5orf45DKFZp686L2452LOC51149MGC65027MGC78537
Gene Description
MRN complex interacting protein
Chromosome
5
Position
179835133-179862173
Supporting publications (n)
4
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainCell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificdeep-layer near-projecting
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
343
Mass
37,743
Sequence
MASLQRSRVLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAYGEGSGADCRRHVQKLNLLQGQVSELPLRSLEETVSASEEENVGHQQAGNVKQQEKSQPSESRWLKYLEKDSQELELEGTGVCFSKQPSSKMEEPGPRFSQDLPRKRKWSRSTVQPPCSRGVQDSGGSEVAWGPQKGQAGLTWKVKQGSSPCLQENSADCSAGELRGPGKELWSPIQQVTATSSKWAQFVLPPRKSSHVDSEQPRSLQRDPRPAGPAQAKQGTPRAQASREGLSRPTAAVQLPRATHPVTSGSERPCGKTSWDARTPWAEGGPLVLEAQNPRPTRLCDLFITGEDFDDDV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NTE8-1; Sequence=Displayed; Name=2; IsoId=Q6NTE8-2; Sequence=VSP_032560, VSP_032561, VSP_032562; Name=3; IsoId=Q6NTE8-3; Sequence=VSP_047227
Alternative Sequence
1..42; MASLQRSRVLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQ -> MQSARAWLPGDCTSRDGVASAFSGATLLQLPPLPGAPGKKECQVDMQSLWREAVLFAEFPRHGAPASELPVPSGSEMDGAESGK (in isoform 2); 43..97; Missing (in isoform 3); 222..229; VTATSSKW -> DGYKEILF (in isoform 2); 230..343; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
87..104; Polar residues; 193..202; Polar residues; 240..255; Basic and acidic residues
Motif
148..151; Nuclear localization signal (NLS)
Region
75..104; Disordered; 128..178; Disordered; 193..212; Disordered; 213..237; Necessary for the association with the MRN complex; 230..324; Disordered
Protein Families
MRNIP family
Sequence Similarities
Belongs to the MRNIP family.
Clinical Relevance
Antibody
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No related sentences available |
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No related sentences available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |