Protein detail

KANK3

KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47)

Entry name KANK3	UniProt ID Q6NY19	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000186994

Entrez Gene Symbol

KANK3

Gene Synonym (2)

ANKRD47FLJ46061

Gene Description

KN motif and ankyrin repeat domains 3

Chromosome

Position

8322584-8343262

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificadrenal glandCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificlower rhombic lip

Function & Pathway4

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	7	38731868 24505114 28963552 30608700 40784529 40098346 31588238

Sequence, Structure & Domains9

Sequences

Length

821

Mass

85,893

Sequence

MAKFALNQNLPDLGGPRLCPVPAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPGLAGARSPGAWTSSESLASDDGGAPGILSQGAPSGLLMQPLSPRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRGSGRSSPAPNLAPASPGPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQPEPDGEAETRPDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQTREVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRASLEHQRGVSELLRGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAEAPSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREACVALQRQLSRPRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSESPPGSQTATPGEGECGDNGENPQVQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q6NY19-2; Sequence=Displayed; Name=1; IsoId=Q6NY19-1; Sequence=VSP_061119

Alternative Sequence

795..821; SESPPGSQTATPGEGECGDNGENPQVQ -> AGVQRHNLSSLQPPPPRFKKFSCLSLPSSWDYNSCEPSRLAQLTIF (in isoform 1)

Domain & Motif Annotations

Compositional Bias

1..10; Polar residues; 77..88; Low complexity; 128..150; Basic and acidic residues; 151..181; Low complexity; 237..261; Basic and acidic residues; 388..400; Low complexity; 494..507; Low complexity; 787..805; Polar residues

Repeat

622..652; ANK 1; 656..690; ANK 2; 695..724; ANK 3; 728..758; ANK 4; 762..785; ANK 5

Coiled Coil

181..230; 367..404

Region

1..36; Disordered; 58..184; Disordered; 224..333; Disordered; 385..547; Disordered; 784..821; Disordered

Clinical Relevance1

Antibody

HPA051153

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available