Protein detail

KANK3

KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47)

Protein symbol
KANK3
UniProt ID
Q6NY19
EVMP score
0.38
Frequency
1
Transmembrane count
Protein classification
Predicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000186994
Entrez Gene Symbol
KANK3
Gene Synonym
ANKRD47FLJ46061
Gene Description
KN motif and ankyrin repeat domains 3
Chromosome
19
Position
8322584-8343262
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificlower rhombic lip
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

2 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryWestern blottingELISA738731868245051142896355230608700407845294009834631588238
Sequence, Structure & Domains

Sequences

Length
821
Mass
85,893
Sequence
MAKFALNQNLPDLGGPRLCPVPAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPGLAGARSPGAWTSSESLASDDGGAPGILSQGAPSGLLMQPLSPRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRGSGRSSPAPNLAPASPGPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQPEPDGEAETRPDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQTREVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRASLEHQRGVSELLRGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAEAPSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREACVALQRQLSRPRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSESPPGSQTATPGEGECGDNGENPQVQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q6NY19-2; Sequence=Displayed; Name=1; IsoId=Q6NY19-1; Sequence=VSP_061119
Alternative Sequence
795..821; SESPPGSQTATPGEGECGDNGENPQVQ -> AGVQRHNLSSLQPPPPRFKKFSCLSLPSSWDYNSCEPSRLAQLTIF (in isoform 1)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
1..10; Polar residues; 77..88; Low complexity; 128..150; Basic and acidic residues; 151..181; Low complexity; 237..261; Basic and acidic residues; 388..400; Low complexity; 494..507; Low complexity; 787..805; Polar residues
Repeat
622..652; ANK 1; 656..690; ANK 2; 695..724; ANK 3; 728..758; ANK 4; 762..785; ANK 5
Coiled Coil
181..230; 367..404
Region
1..36; Disordered; 58..184; Disordered; 224..333; Disordered; 385..547; Disordered; 784..821; Disordered
Clinical Relevance
Antibody
HPA051153