Protein detail
PPR18
Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)
Protein symbol PPR18 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1949phostensin
Gene Description
Protein phosphatase 1 regulatory subunit 18
Chromosome
6
Position
30676389-30687895
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificLoop of henle epithelial cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Biological Process
Canonical Pathways
- M103 Pid s1p s1p1 pathway
- M155 Pid s1p meta pathway
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 28986585 |
Sequence, Structure & Domains
Sequences
Length
613
Mass
67,943
Sequence
MATIPDWKLQLLARRRQEEASVRGREKAERERLSQMPAWKRGLLERRRAKLGLSPGEPSPVLGTVEAGPPDPDESAVLLEAIGPVHQNRFIRQERQQQQQQQQRSEELLAERKPGPLEARERRPSPGEMRDQSPKGRESREERLSPRETRERRLGIGGAQELSLRPLEARDWRQSPGEVGDRSSRLSEAWKWRLSPGETPERSLRLAESREQSPRRKEVESRLSPGESAYQKLGLTEAHKWRPDSRESQEQSLVQLEATEWRLRSGEERQDYSEECGRKEEWPVPGVAPKETAELSETLTREAQGNSSAGVEAAEQRPVEDGERGMKPTEGWKWTLNSGKAREWTPRDIEAQTQKPEPPESAEKLLESPGVEAGEGEAEKEEAGAQGRPLRALQNCCSVPSPLPPEDAGTGGLRQQEEEAVELQPPPPAPLSPPPPAPTAPQPPGDPLMSRLFYGVKAGPGVGAPRRSGHTFTVNPRRSVPPATPATPTSPATVDAAVPGAGKKRYPTAEEILVLGGYLRLSRSCLAKGSPERHHKQLKISFSETALETTYQYPSESSVLEELGPEPEVPSAPNPPAAQPDDEEDEEELLLLQPELQGGLRTKALIVDESCRR
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=110 kDa, phostensin-beta; IsoId=Q6NYC8-1; Sequence=Displayed; Name=2; IsoId=Q6NYC8-2; Sequence=VSP_014258, VSP_014259; Name=3; IsoId=Q6NYC8-3; Sequence=VSP_057118, VSP_057119; Name=4; Synonyms=26kDa, phostensin-alpha; IsoId=Q6NYC8-4; Sequence=VSP_057117
Alternative Sequence
1..448; Missing (in isoform 4); 1..325; Missing (in isoform 3); 337..377; NSGKAREWTPRDIEAQTQKPEPPESAEKLLESPGVEAGEGE -> IMSLAGKGNQHLVTCFPHPVSGGRANCPISTLIQSPWCGWG (in isoform 2); 378..613; Missing (in isoform 2); 562..582; ELGPEPEVPSAPNPPAAQPDD -> RRRAKLGLSPGEPSPVLGTVEAGPPDPDESAVLLEAIGPVHQNRFIRQERQQQQQQQQRSEELLAERKPGPLEARERRPSPGEMRDQSPKGRESR (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
18..33; Basic and acidic residues; 104..154; Basic and acidic residues; 167..191; Basic and acidic residues; 199..221; Basic and acidic residues; 266..282; Basic and acidic residues; 295..309; Polar residues; 314..327; Basic and acidic residues; 340..350; Basic and acidic residues; 357..366; Basic and acidic residues; 424..446; Pro residues; 476..499; Low complexity; 567..578; Pro residues; 580..589; Acidic residues
Region
18..231; Disordered; 266..500; Disordered; 552..595; Disordered
Clinical Relevance
Interaction Protein
ENSG00000100109ENSG00000136436ENSG00000172531
Interaction Count
3
Interaction Dataset
intact_biogridintact_biogrid_bioplex