Protein detail
PPR18
Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)
Entry name PPR18 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
KIAA1949phostensin
Gene Description
Protein phosphatase 1 regulatory subunit 18
Chromosome
6
Position
30676389-30687895
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization3
Cell SpecificLoop of henle epithelial cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Canonical Pathways (2)
- M103 Pid s1p s1p1 pathway
- M155 Pid s1p meta pathway
Mediation Categories
Other mediation
Relations & Evidence6
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 28986585 |
Sequence, Structure & Domains7
Sequences
Length
613
Mass
67,943
Sequence
MATIPDWKLQLLARRRQEEASVRGREKAERERLSQMPAWKRGLLERRRAKLGLSPGEPSPVLGTVEAGPPDPDESAVLLEAIGPVHQNRFIRQERQQQQQQQQRSEELLAERKPGPLEARERRPSPGEMRDQSPKGRESREERLSPRETRERRLGIGGAQELSLRPLEARDWRQSPGEVGDRSSRLSEAWKWRLSPGETPERSLRLAESREQSPRRKEVESRLSPGESAYQKLGLTEAHKWRPDSRESQEQSLVQLEATEWRLRSGEERQDYSEECGRKEEWPVPGVAPKETAELSETLTREAQGNSSAGVEAAEQRPVEDGERGMKPTEGWKWTLNSGKAREWTPRDIEAQTQKPEPPESAEKLLESPGVEAGEGEAEKEEAGAQGRPLRALQNCCSVPSPLPPEDAGTGGLRQQEEEAVELQPPPPAPLSPPPPAPTAPQPPGDPLMSRLFYGVKAGPGVGAPRRSGHTFTVNPRRSVPPATPATPTSPATVDAAVPGAGKKRYPTAEEILVLGGYLRLSRSCLAKGSPERHHKQLKISFSETALETTYQYPSESSVLEELGPEPEVPSAPNPPAAQPDDEEDEEELLLLQPELQGGLRTKALIVDESCRR
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=110 kDa, phostensin-beta; IsoId=Q6NYC8-1; Sequence=Displayed; Name=2; IsoId=Q6NYC8-2; Sequence=VSP_014258, VSP_014259; Name=3; IsoId=Q6NYC8-3; Sequence=VSP_057118, VSP_057119; Name=4; Synonyms=26kDa, phostensin-alpha; IsoId=Q6NYC8-4; Sequence=VSP_057117
Alternative Sequence
1..448; Missing (in isoform 4); 1..325; Missing (in isoform 3); 337..377; NSGKAREWTPRDIEAQTQKPEPPESAEKLLESPGVEAGEGE -> IMSLAGKGNQHLVTCFPHPVSGGRANCPISTLIQSPWCGWG (in isoform 2); 378..613; Missing (in isoform 2); 562..582; ELGPEPEVPSAPNPPAAQPDD -> RRRAKLGLSPGEPSPVLGTVEAGPPDPDESAVLLEAIGPVHQNRFIRQERQQQQQQQQRSEELLAERKPGPLEARERRPSPGEMRDQSPKGRESR (in isoform 3)
Domain & Motif Annotations
Compositional Bias
18..33; Basic and acidic residues; 104..154; Basic and acidic residues; 167..191; Basic and acidic residues; 199..221; Basic and acidic residues; 266..282; Basic and acidic residues; 295..309; Polar residues; 314..327; Basic and acidic residues; 340..350; Basic and acidic residues; 357..366; Basic and acidic residues; 424..446; Pro residues; 476..499; Low complexity; 567..578; Pro residues; 580..589; Acidic residues
Region
18..231; Disordered; 266..500; Disordered; 552..595; Disordered
Clinical Relevance5
Drugs (2)
Interaction Protein (3)
ENSG00000100109ENSG00000136436ENSG00000172531
Interaction Count
3
Interaction Dataset (2)
intact_biogridintact_biogrid_bioplex
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |