Protein detail

CAVN1

Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor)

Entry name CAVN1	UniProt ID Q6NZI2	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism

Ensembl

ENSG00000177469

Entrez Gene Symbol

CAVIN1

Gene Synonym (3)

cavin-1CGL4PTRF

Gene Description

Caveolae associated protein 1

Chromosome

Position

42402449-42423256

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells

Function & Pathway6

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism

Cellular Component (11)

Page 1 of 2

Molecular Function (4)

Biological Process (3)

Reactome (7)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence16

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CAVIN1	AURKB	Q96GD4	S	300	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cavin_caveolae	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CAVIN1 MAGI2 MAGI3 RHBDL1 TCL1B	O75783 O95988 Q5TCQ9 Q6NZI2 Q86UL8	0:0:0:0:0	hu.MAP2
CAVIN1 MAGI3 TCL1B	O95988 Q5TCQ9 Q6NZI2	0:0:0	hu.MAP2
CAVIN1 KCNJ6 MB21D2	P48051 Q6NZI2 Q8IYB1	0:0:0	hu.MAP2
CAV1 CAVIN1 GTF3C4 TMED10	P49755 Q03135 Q6NZI2 Q9UKN8	0:0:0:0	Havugimana2012	Havugimana2012:C_347
CAVIN1	Q6NZI2	3	PDB	PDB:9eg6
CAVIN1 FAM9A GOPC NAP1L3	Q6NZI2 Q8IZU1 Q99457 Q9HD26	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains13

Sequences

Length

390

Mass

43,476

Sequence

MEDPTLYIVERPLPGYPDAEAPEPSSAGAQAAEEPSGAGSEELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSISKSLKESEALPEKEGEELGEGERPEEDAAALELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPAERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGQVEVLKATEMVEVGADDDEGGAERGEAGDLRRGSSPDVHALLEITEESDAVLVDKSDSD

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NZI2-1; Sequence=Displayed; Name=2; IsoId=Q6NZI2-2; Sequence=VSP_051625; Name=3; IsoId=Q6NZI2-3; Sequence=VSP_051624

Alternative Sequence

1..193; MEDPTLYIVERPLPGYPDAEAPEPSSAGAQAAEEPSGAGSEELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSISKSLKESEALPEKEGEELGEGERPE -> M (in isoform 3); 96..185; Missing (in isoform 2)

3D Structural Models

Helix

57..94

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

22..40; Low complexity; 172..181; Basic and acidic residues; 182..201; Acidic residues; 352..365; Basic and acidic residues

Coiled Coil

199..282

Domain (CC)

The leucine-zipper domain 1 is essential for its localization in the caveolae.

Region

1..98; Required for homotrimerization and for interaction with CAVIN2 and CAVIN3; 1..40; Disordered; 52..62; Nuclear export signal; 53..75; Leucine-zipper 1; 136..152; Nuclear localization signal; 166..186; Leucine-zipper 2; 172..201; Disordered; 233..249; Nuclear localization signal; 257..297; Leucine-zipper 3; 344..366; Disordered

Protein Families

CAVIN family

Sequence Similarities

Belongs to the CAVIN family.

Clinical Relevance5

Disease Involvement (2)

Congenital generalized lipodystrophyDiabetes mellitus

Antibody (2)

HPA049838 HPA074213

Interaction Protein (6)

ENSG00000105974ENSG00000143756ENSG00000155329ENSG00000168497ENSG00000170955ENSG00000268988

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available