Protein detail
CAVN1
Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor)
Protein symbol CAVN1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Ensembl
Entrez Gene Symbol
Gene Synonym
cavin-1CGL4PTRF
Gene Description
Caveolae associated protein 1
Chromosome
17
Position
42402449-42423256
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CAVIN1 | AURKB | Q96GD4 | S | 300 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cavin_caveolae | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CAVIN1MAGI2MAGI3RHBDL1TCL1B | O75783O95988Q5TCQ9Q6NZI2Q86UL8 | 0:0:0:0:0 | hu.MAP2 | |||
| CAVIN1MAGI3TCL1B | O95988Q5TCQ9Q6NZI2 | 0:0:0 | hu.MAP2 | |||
| CAVIN1KCNJ6MB21D2 | P48051Q6NZI2Q8IYB1 | 0:0:0 | hu.MAP2 | |||
| CAV1CAVIN1GTF3C4TMED10 | P49755Q03135Q6NZI2Q9UKN8 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_347 | ||
| CAVIN1 | Q6NZI2 | 3 | PDB | PDB:9eg6 | ||
| CAVIN1FAM9AGOPCNAP1L3 | Q6NZI2Q8IZU1Q99457Q9HD26 | 0:0:0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
390
Mass
43,476
Sequence
MEDPTLYIVERPLPGYPDAEAPEPSSAGAQAAEEPSGAGSEELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSISKSLKESEALPEKEGEELGEGERPEEDAAALELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPAERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGQVEVLKATEMVEVGADDDEGGAERGEAGDLRRGSSPDVHALLEITEESDAVLVDKSDSD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NZI2-1; Sequence=Displayed; Name=2; IsoId=Q6NZI2-2; Sequence=VSP_051625; Name=3; IsoId=Q6NZI2-3; Sequence=VSP_051624
Alternative Sequence
1..193; MEDPTLYIVERPLPGYPDAEAPEPSSAGAQAAEEPSGAGSEELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSISKSLKESEALPEKEGEELGEGERPE -> M (in isoform 3); 96..185; Missing (in isoform 2)
3D Structural Models
Helix
57..94
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
22..40; Low complexity; 172..181; Basic and acidic residues; 182..201; Acidic residues; 352..365; Basic and acidic residues
Coiled Coil
199..282
Domain (CC)
The leucine-zipper domain 1 is essential for its localization in the caveolae.
Region
1..98; Required for homotrimerization and for interaction with CAVIN2 and CAVIN3; 1..40; Disordered; 52..62; Nuclear export signal; 53..75; Leucine-zipper 1; 136..152; Nuclear localization signal; 166..186; Leucine-zipper 2; 172..201; Disordered; 233..249; Nuclear localization signal; 257..297; Leucine-zipper 3; 344..366; Disordered
Protein Families
CAVIN family
Sequence Similarities
Belongs to the CAVIN family.