Protein detail

DUS1L

tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.88) (tRNA-dihydrouridine synthase 1-like)

Entry name
DUS1L
UniProt ID
Q6P1R4
EVMP score
0.38
Frequency
2
Transmembrane count
Protein classification
EnzymesPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.88) (tRNA-dihydrouridine synthase 1-like)
Protein Class
EnzymesPredicted intracellular proteins
Protein Function
  • Enzymes
  • ENZYME proteins:Oxidoreductases
  • Predicted intracellular proteins
Ensembl
ENSG00000169718
Entrez Gene Symbol
DUS1L
Gene Synonym
DUS1PP3111
Gene Description
Dihydrouridine synthase 1 like
Chromosome
17
Position
82057506-82065887
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
DUS1L fluorescence
Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
  • Enzymes
  • ENZYME proteins:Oxidoreductases
  • Predicted intracellular proteins
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryWestern blotting3401894973871651241068253
Sequence, Structure & Domains

Sequences

Length
473
Mass
53,230
Sequence
MPKLQGFEFWSRTLRGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKENLYCEVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGAFLQDEWDLLQRMILLAHEKLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKEQKGPLSGAASWEHIKAVRKAVAIPVFANGNIQCLQDVERCLRDTGVQGVMSAEGNLHNPALFEGRSPAVWELAEEYLDIVREHPCPLSYVRAHLFKLWHHTLQVHQELREELAKVKTLEGIAAVSQELKLRCQEEISRQEGAKPTGDLPFHWICQPYIRPGPREGSKEKAGARSKRALEEEEGGTEVLSKNKQKKQLRNPHKTFDPSLKPKYAKCDQCGNPKGNRCVFSLCRGCCKKRASKETADCPGHGLLFKTKLEKSLAWKEAQPELQEPQPAAPGTPGGFSEVMGSALA

3D Structural Models

Domain & Motif Annotations

Compositional Bias
341..351; Basic and acidic residues; 371..381; Basic residues
Region
339..386; Disordered; 444..473; Disordered
Protein Families
  • Dus family
  • Dus1 subfamily
Sequence Similarities
Belongs to the Dus family. Dus1 subfamily.
Clinical Relevance
Drug Targets
Clinical trial target
Antibody
HPA023384