Protein detail

KCC1B

Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase)

Protein symbol KCC1B	UniProt ID Q6P2M8	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase)

Protein Class

EnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CAMK Ser/Thr protein kinases

Ensembl

ENSG00000130822

Entrez Gene Symbol

PNCK

Gene Synonym

CaMK1bMGC45419

Gene Description

Pregnancy up-regulated nonubiquitous CaM kinase

Chromosome

Position

153669733-153689010

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificDecidual stromal cellsSingle-Nuclei Brain SpecificpericyteBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CAMK Ser/Thr protein kinases

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KCC1B	Q6P2M8	IF4G3	O43432	Yes	Yes	No	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:22514323 SIGNOR:22514323
KCC1B	Q6P2M8	HS90A	P07900	Yes	No	No	PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:21325639
KCC1B	Q6P2M8	HS90B	P08238	Yes	No	No	PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:30992362

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]Small R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing	35	40985879 26826536 36064647 26098714 32106990 38113368 28680152 40465195 37322475 33304478 36497184 34064677 40189497 41068253 33592500 32854315 34473505 38891077 32560723 31617158 32916986 41307968 36146834 33309826 40840701 31805958 38607062 32230970 38207106 34576246 37204515 39001700 39207047 37926756 40831280

Sequence, Structure & Domains

Sequences

Length

343

Mass

38,500

Sequence

MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6P2M8-1; Sequence=Displayed; Name=2; IsoId=Q6P2M8-2; Sequence=VSP_012635; Name=3; IsoId=Q6P2M8-3; Sequence=VSP_012634; Name=4; IsoId=Q6P2M8-5; Sequence=VSP_039091; Name=5; IsoId=Q6P2M8-6; Sequence=VSP_043373

Alternative Sequence

1..102; Missing (in isoform 3); 1; M -> MEAAFGQVAGSACPRRGGEGRDWKAESLADLWPKSSPGDSHRWCKGPGAGPAGPQLREAARASSGLGGGGRHPSRIPAIALQDM (in isoform 4); 1; M -> MWRRVCGGLAGRRPSGDM (in isoform 5); 179; V -> AEPVTLSGMAACVPVRASVCLWPP (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Domain (FT)

15..270; Protein kinase

Region

290..311; Calmodulin-binding; 319..343; Disordered

Protein Families

Protein kinase superfamily
CAMK Ser/Thr protein kinase family
CaMK subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Clinical Relevance

Antibody

HPA007458