Protein detail
KCC1B
Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase)
Entry name KCC1B | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
- Kinases:CAMK Ser/Thr protein kinases
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CaMK1bMGC45419
Gene Description
Pregnancy up-regulated nonubiquitous CaM kinase
Chromosome
X
Position
153669733-153689010
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificDecidual stromal cellsSingle-Nuclei Brain SpecificpericyteBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
- Kinases:CAMK Ser/Thr protein kinases
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence10
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| receptor | receptor | scConnect | Yes |
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KCC1B | Q6P2M8 | IF4G3 | O43432 | Yes | Yes | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:22514323SIGNOR:22514323 | |
| KCC1B | Q6P2M8 | HS90A | P07900 | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:21325639 | ||
| KCC1B | Q6P2M8 | HS90B | P08238 | Yes | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:30992362 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]Small R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing | 35 | 4098587926826536360646472609871432106990381133682868015240465195373224753330447836497184340646774018949741068253335925003285431534473505388910773256072331617158329169864130796836146834333098264084070131805958386070623223097038207106345762463720451539001700392070473792675640831280 |
Sequence, Structure & Domains
Sequences
Length
343
Mass
38,500
Sequence
MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6P2M8-1; Sequence=Displayed; Name=2; IsoId=Q6P2M8-2; Sequence=VSP_012635; Name=3; IsoId=Q6P2M8-3; Sequence=VSP_012634; Name=4; IsoId=Q6P2M8-5; Sequence=VSP_039091; Name=5; IsoId=Q6P2M8-6; Sequence=VSP_043373
Alternative Sequence
1..102; Missing (in isoform 3); 1; M -> MEAAFGQVAGSACPRRGGEGRDWKAESLADLWPKSSPGDSHRWCKGPGAGPAGPQLREAARASSGLGGGGRHPSRIPAIALQDM (in isoform 4); 1; M -> MWRRVCGGLAGRRPSGDM (in isoform 5); 179; V -> AEPVTLSGMAACVPVRASVCLWPP (in isoform 2)
Domain & Motif Annotations
Domain (FT)
15..270; Protein kinase
Region
290..311; Calmodulin-binding; 319..343; Disordered
Protein Families (3)
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- CaMK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Clinical Relevance
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |