Protein detail
KLC3
Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)
Protein symbol KLC3 | UniProt ID | EVMP score 0.72 |
Frequency 14 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)
Protein Class
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ12387
Gene Description
Kinesin light chain 2
Chromosome
11
Position
66257294-66267860
Frequency
14
EVMP Score
0.72
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificintermediate monocyteBlood Lineage SpecificmonocytesSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Biological Process
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-6811434 copi dependent golgi to er retrograde traffic
- R-hsa-983231 factors involved in megakaryocyte development and platelet production
- R-hsa-8856688 golgi to er retrograde transport
- R-hsa-109582 hemostasis
- R-hsa-6811442 intra golgi and retrograde golgi to er traffic
- R-hsa-983189 kinesins
- R-hsa-199991 membrane trafficking
- R-hsa-2132295 mhc class ii antigen presentation
- R-hsa-5625970 rho gtpases activate ktn1
- R-hsa-195258 rho gtpase effectors
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| KLC2 | PRKAA1 | Q13131 | S | 582 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:21725060ProtMapper:21725060 |
| KLC2 | PRKAA1 | Q13131 | S | 545 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| KLC2 | PRKAA2 | P54646 | S | 582 | phosphorylation | SIGNOR | SIGNOR:21725060 |
| KLC2 | PRKAG1 | P54619 | S | 582 | phosphorylation | SIGNOR | SIGNOR:21725060 |
| KLC2 | PRKAB2 | O43741 | S | 582 | phosphorylation | SIGNOR | SIGNOR:21725060 |
| KLC2 | PRKAG3 | Q9UGI9 | S | 582 | phosphorylation | SIGNOR | SIGNOR:21725060 |
| KLC2 | PRKAB1 | Q9Y478 | S | 582 | phosphorylation | SIGNOR | SIGNOR:21725060 |
| KLC2 | PRKAG2 | Q9UGJ0 | S | 582 | phosphorylation | SIGNOR | SIGNOR:21725060 |
| KLC2 | GSK3B | P49841 | S | 608 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| KLC2 | RPS6KA3 | P51812 | S | 582 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478 | KLC2 | Q9H0B6 | Yes | Yes | No | SIGNOR | SIGNOR:21725060 | |
| AAPK1 | Q13131 | KLC2 | Q9H0B6 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:21725060ProtMapper:21725060 |
| KLC2 | Q9H0B6 | FYCO1 | Q9BQS8 | Yes | Yes | No | DIPSIGNOR | DIP:25855459SIGNOR:25855459 |
| GSK3B | P49841 | KLC2 | Q9H0B6 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:20534517 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| KLC2-nKHC-uKHC kinesin complex | KIF5AKIF5BKIF5CKLC2 | O60282P33176Q12840Q9H0B6 | 1:1:1:1 | Compleat | Compleat:HC2016 | 9624122 |
| AMPD2ETF1GSPT1GSPT2KLC2LSM2 | P15170P62495Q01433Q8IYD1Q9H0B6Q9Y333 | 0:0:0:0:0:0 | hu.MAP2 | |||
| KIF5BKLC2KLC4 | P33176Q9H0B6Q9NSK0 | 0:0:0 | hu.MAP2 | |||
| KLC2 | Q9H0B6 | 2 | PDB | PDB:3edtPDB:3ceq |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass SpectrometryElisa | 1 | 38071653 |
Sequence, Structure & Domains
Sequences
Length
504
Mass
55,364
Sequence
MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAMSLNTLNVDAPRAPGTQFPSWHLDKAPRTLSASTQDLSPH
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P597-1; Sequence=Displayed; Name=2; IsoId=Q6P597-2; Sequence=VSP_017832; Name=3; IsoId=Q6P597-3; Sequence=VSP_017831
Alternative Sequence
1; M -> MIPQTPHHCSPGAAM (in isoform 3); 163; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
158..167; Low complexity; 494..504; Polar residues
Repeat
207..240; TPR 1; 249..282; TPR 2; 291..324; TPR 3; 333..366; TPR 4; 375..408; TPR 5
Coiled Coil
90..150
Domain (CC)
The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).
Region
153..197; Disordered; 411..438; Disordered; 472..504; Disordered
Protein Families
Kinesin light chain family
Sequence Similarities
Belongs to the kinesin light chain family.
Clinical Relevance
Disease Involvement
Hereditary spastic paraplegiaNeurodegenerationNeuropathy
Interaction Protein
ENSG00000104892ENSG00000108953ENSG00000109971ENSG00000126214ENSG00000134308ENSG00000137171ENSG00000164924ENSG00000168280ENSG00000170027ENSG00000170759ENSG00000175793
Interaction Count
11
Interaction Dataset
biogrid_opencellintact_biogridbiogrid_bioplex