Protein detail

KLC3

Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)

Entry name KLC3	UniProt ID Q6P597	EVMP confidence score 0.72
Supporting publications (n) 14	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)

Protein Class (4)

Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Ensembl

ENSG00000174996

Entrez Gene Symbol

KLC2

Gene Synonym

FLJ12387

Gene Description

Kinesin light chain 2

Chromosome

Position

66257294-66267860

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization8

Tissue Specificlymphoid tissueCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificintermediate monocyteBlood Lineage SpecificmonocytesSecretome LocationIntracellular and membraneSecretome FunctionReceptor

Function & Pathway7

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component (11)

Page 1 of 2

Molecular Function (3)

Biological Process (3)

KEGG (8)

Reactome (13)

Page 1 of 2

Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence24

Enzyme-Mediated Modification (10)

10 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
KLC2	PRKAA1	Q13131	S	582	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:21725060 ProtMapper:21725060
KLC2	PRKAA1	Q13131	S	545	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
KLC2	PRKAA2	P54646	S	582	phosphorylation	SIGNOR	SIGNOR:21725060
KLC2	PRKAG1	P54619	S	582	phosphorylation	SIGNOR	SIGNOR:21725060
KLC2	PRKAB2	O43741	S	582	phosphorylation	SIGNOR	SIGNOR:21725060
KLC2	PRKAG3	Q9UGI9	S	582	phosphorylation	SIGNOR	SIGNOR:21725060
KLC2	PRKAB1	Q9Y478	S	582	phosphorylation	SIGNOR	SIGNOR:21725060
KLC2	PRKAG2	Q9UGJ0	S	582	phosphorylation	SIGNOR	SIGNOR:21725060
KLC2	GSK3B	P49841	S	608	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
KLC2	RPS6KA3	P51812	S	582	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
	COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478	KLC2	Q9H0B6	Yes	Yes	No	SIGNOR	SIGNOR:21725060
AAPK1	Q13131	KLC2	Q9H0B6	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper	SIGNOR:21725060 ProtMapper:21725060
KLC2	Q9H0B6	FYCO1	Q9BQS8	Yes	Yes	No	DIPSIGNOR	DIP:25855459 SIGNOR:25855459
GSK3B	P49841	KLC2	Q9H0B6	Yes	No	Yes	PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:20534517

Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
KLC2-nKHC-uKHC kinesin complex	KIF5A KIF5B KIF5C KLC2	O60282 P33176 Q12840 Q9H0B6	1:1:1:1	Compleat	Compleat:HC2016	9624122
	AMPD2 ETF1 GSPT1 GSPT2 KLC2 LSM2	P15170 P62495 Q01433 Q8IYD1 Q9H0B6 Q9Y333	0:0:0:0:0:0	hu.MAP2
	KIF5B KLC2 KLC4	P33176 Q9H0B6 Q9NSK0	0:0:0	hu.MAP2
	KLC2	Q9H0B6	2	PDB	PDB:3edtPDB:3ceq

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass SpectrometryElisa	1	38071653

Sequence, Structure & Domains12

Sequences

Length

504

Mass

55,364

Sequence

MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAMSLNTLNVDAPRAPGTQFPSWHLDKAPRTLSASTQDLSPH

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P597-1; Sequence=Displayed; Name=2; IsoId=Q6P597-2; Sequence=VSP_017832; Name=3; IsoId=Q6P597-3; Sequence=VSP_017831

Alternative Sequence

1; M -> MIPQTPHHCSPGAAM (in isoform 3); 163; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

158..167; Low complexity; 494..504; Polar residues

Repeat

207..240; TPR 1; 249..282; TPR 2; 291..324; TPR 3; 333..366; TPR 4; 375..408; TPR 5

Coiled Coil

90..150

Domain (CC)

The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).

Region

153..197; Disordered; 411..438; Disordered; 472..504; Disordered

Protein Families

Kinesin light chain family

Sequence Similarities

Belongs to the kinesin light chain family.

Clinical Relevance5

Disease Involvement (3)

Hereditary spastic paraplegiaNeurodegenerationNeuropathy

Antibody (2)

HPA040416 HPA040434

Interaction Protein (11)

ENSG00000104892ENSG00000108953ENSG00000109971ENSG00000126214ENSG00000134308ENSG00000137171ENSG00000164924ENSG00000168280ENSG00000170027ENSG00000170759ENSG00000175793

Interaction Count

Interaction Dataset (3)

biogrid_opencellintact_biogridbiogrid_bioplex

Supporting Publications14

PMID	Title	Abstract
26538482	Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles.	No abstract available
27723984	Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection.	No abstract available
30071318	Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.	No abstract available
30451371	Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance.	No abstract available
30760538	Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
34071777	Proteome Characterization of BALF Extracellular Vesicles in Idiopathic Pulmonary Fibrosis: Unveiling Undercover Molecular Pathways.	No abstract available
36362114	Extracellular Vesicles in Diffuse Large B Cell Lymphoma: Characterization and Diagnostic Potential.	No abstract available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available

Page 1 of 2Next