Protein detail

LMOD2

Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin)

Entry name LMOD2	UniProt ID Q6P5Q4	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin)

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000170807

Entrez Gene Symbol

LMOD2

Gene Description

Leiomodin 2

Chromosome

Position

123655866-123664290

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificExtravillous trophoblasts

Function & Pathway6

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04820 Cytoskeleton in muscle cells

Mediation Categories

Fusion and delivery mediation

Relations & Evidence4

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains15

Sequences

Length

547

Mass

61,675

Sequence

MSTFGYRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVGLRQKSLTEKTPTGTFSREALMAYWEKESQKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEEEEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPPPPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P5Q4-1; Sequence=Displayed; Name=2; IsoId=Q6P5Q4-2; Sequence=VSP_029526, VSP_029528; Name=3; IsoId=Q6P5Q4-3; Sequence=VSP_029525, VSP_029527

Alternative Sequence

78..129; QKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEEE -> LLLLPLLHSQRKSSLPETLQKSSNNRRVPNGHYKMDKKRKKGKRSRNSQTVF (in isoform 3); 110..138; SEVSEEVYTEEEEEESQEEEEEEDSDEEE -> RRSPRRKRRKKTVTKRKEQLKLQKGLMEL (in isoform 2); 130..547; Missing (in isoform 3); 139..547; Missing (in isoform 2)

3D Structural Models

Turn

7..9; 12..15; 22..24; 236..238

Helix

3..6; 18..21; 27..40; 199..208; 226..235; 254..264; 282..291; 292..294; 313..321; 322..324; 338..362; 460..468; 490..493; 495..497; 520..530; 534..536

Beta Strand

215..217; 243..250; 272..278; 300..302; 330..332; 502..504

3D Structure

NMR spectroscopy (1); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

95..104; Acidic residues; 112..139; Acidic residues; 149..160; Polar residues; 352..367; Basic and acidic residues; 419..449; Pro residues; 465..475; Polar residues; 477..487; Basic residues; 494..512; Basic and acidic residues

Coiled Coil

16..41; 113..148

Domain (FT)

521..540; WH2

Region

1..161; Interaction with actin 1; 1..47; Interaction with tropomyosin alpha; 91..162; Disordered; 162..497; Interaction with actin 2; 352..533; Disordered; 521..540; Interaction with actin 3

Protein Families

Tropomodulin family

Sequence Similarities

Belongs to the tropomodulin family.

Clinical Relevance2

Disease Involvement (2)

CardiomyopathyDisease variant

Antibody (2)

HPA046370 HPA051039

Supporting Publications3

PMID	Title	Abstract
30550287	Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available