Protein detail
LMOD2
Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin)
Entry name LMOD2 | UniProt ID | EVMP score 0.38 |
Frequency 3 | Transmembrane count | Protein classification Disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin)
Protein Class
Disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Leiomodin 2
Chromosome
7
Position
123655866-123664290
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificExtravillous trophoblasts
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
547
Mass
61,675
Sequence
MSTFGYRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVGLRQKSLTEKTPTGTFSREALMAYWEKESQKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEEEEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPPPPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P5Q4-1; Sequence=Displayed; Name=2; IsoId=Q6P5Q4-2; Sequence=VSP_029526, VSP_029528; Name=3; IsoId=Q6P5Q4-3; Sequence=VSP_029525, VSP_029527
Alternative Sequence
78..129; QKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEEE -> LLLLPLLHSQRKSSLPETLQKSSNNRRVPNGHYKMDKKRKKGKRSRNSQTVF (in isoform 3); 110..138; SEVSEEVYTEEEEEESQEEEEEEDSDEEE -> RRSPRRKRRKKTVTKRKEQLKLQKGLMEL (in isoform 2); 130..547; Missing (in isoform 3); 139..547; Missing (in isoform 2)
3D Structural Models
Turn
7..9; 12..15; 22..24; 236..238
Helix
3..6; 18..21; 27..40; 199..208; 226..235; 254..264; 282..291; 292..294; 313..321; 322..324; 338..362; 460..468; 490..493; 495..497; 520..530; 534..536
Beta Strand
215..217; 243..250; 272..278; 300..302; 330..332; 502..504
3D Structure
NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
95..104; Acidic residues; 112..139; Acidic residues; 149..160; Polar residues; 352..367; Basic and acidic residues; 419..449; Pro residues; 465..475; Polar residues; 477..487; Basic residues; 494..512; Basic and acidic residues
Coiled Coil
16..41; 113..148
Domain (FT)
521..540; WH2
Region
1..161; Interaction with actin 1; 1..47; Interaction with tropomyosin alpha; 91..162; Disordered; 162..497; Interaction with actin 2; 352..533; Disordered; 521..540; Interaction with actin 3
Protein Families
Tropomodulin family
Sequence Similarities
Belongs to the tropomodulin family.