Protein detail
CCD62
Coiled-coil domain-containing protein 62 (Protein TSP-NY) (Protein aaa)
Entry name CCD62 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Coiled-coil domain-containing protein 62 (Protein TSP-NY) (Protein aaa)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Reproductive system diseases:Reproductive system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CT109ERAP75FLJ40344TSP-NY
Gene Description
Coiled-coil domain containing 62
Chromosome
12
Position
122774526-122827528
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Secretome LocationIntracellular and membraneSecretome FunctionOther
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Reproductive system diseases:Reproductive system diseases
- Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingFlow cytometry | 1 | 38321535 |
Sequence, Structure & Domains
Sequences
Length
684
Mass
77,748
Sequence
MNPPAAFLAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIEPENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPSSKHPEKLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEAPGHMSDVEWMSIFKPSKMQRIVRLKSGCTCSESICGTQHDSPASELIAIQDSHSLGSSKSALREDETESSSNKKNSPTSLLIYKDAPAFNEKASIVLPSQDDFSPTSKLQRLLAESRQMVTDLELSTLLPISHENLTGSATNKSEVPEESAQKNTFVSY
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6P9F0-1; Sequence=Displayed; Name=2; IsoId=Q6P9F0-2; Sequence=VSP_019329; Name=3; IsoId=Q6P9F0-3; Sequence=VSP_019327, VSP_019328
Alternative Sequence
1..239; Missing (in isoform 3); 240..257; IIRLKQEKSCLHDELLFT -> MPNSSPKDPTTASGNGSK (in isoform 3); 668..684; KSEVPEESAQKNTFVSY -> ISHLCGRQKADTNTE (in isoform 2)
Domain & Motif Annotations
Compositional Bias
594..603; Polar residues; 659..669; Polar residues
Motif
634..638; LXXLL motif 1; 650..654; LXXLL motif 2
Coiled Coil
11..160; 199..322
Domain (CC)
Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The first one is essential for the association with ESR1 and ESR2.
Region
579..603; Disordered; 657..684; Disordered
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 39766158 | A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis. | No related sentences available |
| 39940923 | NHERF2 as a Novel Biomarker for Distinguishing MAC Pulmonary Disease from Tuberculosis Based on Proteome Analysis of Serum Extracellular Vesicles. | No related sentences available |