Protein detail
S27A1
Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-)
Protein symbol S27A1 | UniProt ID | EVMP score 0.72 |
Frequency 11 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-)
Protein Function
- Transporters
- Enzymes
- ENZYME proteins:Ligase
- Predicted intracellular proteins
Transmembrane
14..34; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
11
EVMP Score
0.72
Fluorescence & Localization
Cell SpecificPlateletsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Transporters
- Enzymes
- ENZYME proteins:Ligase
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0000166 nucleotide binding
- GO:0004467 long-chain fatty acid-CoA ligase activity
- GO:0005324 long-chain fatty acid transmembrane transporter activity
- GO:0005515 protein binding
- GO:0015225 biotin transmembrane transporter activity
- GO:0015245 fatty acid transmembrane transporter activity
- GO:0015562 efflux transmembrane transporter activity
- GO:0031957 very long-chain fatty acid-CoA ligase activity
- GO:0042802 identical protein binding
- GO:0043539 protein serine/threonine kinase activator activity
- GO:0047676 arachidonate-CoA ligase activity
- GO:0090434 oleoyl-CoA ligase activity
- GO:1901480 oleate transmembrane transporter activity
Biological Process
KEGG
Reactome
- R-hsa-2142753 arachidonate metabolism
- R-hsa-8978868 fatty acid metabolism
- R-hsa-556833 metabolism of lipids
- R-hsa-400206 regulation of lipid metabolism by pparalpha
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-804914 transport of fatty acids
- R-hsa-382551 transport of small molecules
- R-hsa-425397 transport of vitamins nucleosides and related molecules
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
646
Mass
71,108
Sequence
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PCB7-1; Sequence=Displayed; Name=2; IsoId=Q6PCB7-2; Sequence=VSP_055806, VSP_055807
Alternative Sequence
1..8; MRAPGAGA -> MTHVLGTT (in isoform 2); 9..187; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Region
191..475; Sufficient for oligomerization
Protein Families
ATP-dependent AMP-binding enzyme family
Sequence Similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Clinical Relevance
Interaction Protein
ENSG00000162735
Interaction Count
1
Interaction Dataset
biogrid_bioplex