Protein detail
S27A1
Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-)
Entry name S27A1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 11 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-)
Protein Function (4)
- Transporters
- Enzymes
- ENZYME proteins:Ligase
- Predicted intracellular proteins
Transmembrane
14..34; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
11
EVMP confidence score
0.72
Fluorescence & Localization4
Cell SpecificPlateletsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage SpecificB-cells
Function & Pathway7
Protein Function (4)
- Transporters
- Enzymes
- ENZYME proteins:Ligase
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (13)
- GO:0000166 nucleotide binding
- GO:0004467 long-chain fatty acid-CoA ligase activity
- GO:0005324 long-chain fatty acid transmembrane transporter activity
- GO:0005515 protein binding
- GO:0015225 biotin transmembrane transporter activity
- GO:0015245 fatty acid transmembrane transporter activity
- GO:0015562 efflux transmembrane transporter activity
- GO:0031957 very long-chain fatty acid-CoA ligase activity
- GO:0042802 identical protein binding
- GO:0043539 protein serine/threonine kinase activator activity
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Biological Process (3)
KEGG (4)
Reactome (8)
- R-hsa-2142753 arachidonate metabolism
- R-hsa-8978868 fatty acid metabolism
- R-hsa-556833 metabolism of lipids
- R-hsa-400206 regulation of lipid metabolism by pparalpha
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-804914 transport of fatty acids
- R-hsa-382551 transport of small molecules
- R-hsa-425397 transport of vitamins nucleosides and related molecules
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence19
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Protein Complex Composition (1)
Sequence, Structure & Domains8
Sequences
Length
646
Mass
71,108
Sequence
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PCB7-1; Sequence=Displayed; Name=2; IsoId=Q6PCB7-2; Sequence=VSP_055806, VSP_055807
Alternative Sequence
1..8; MRAPGAGA -> MTHVLGTT (in isoform 2); 9..187; Missing (in isoform 2)
Domain & Motif Annotations
Region
191..475; Sufficient for oligomerization
Protein Families
ATP-dependent AMP-binding enzyme family
Sequence Similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Clinical Relevance3
Interaction Protein
ENSG00000162735
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications11
| PMID | Title | Abstract |
|---|---|---|
| 26196085 | Identification of prostate cancer biomarkers in urinary exosomes. | No abstract available |
| 30451371 | Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance. | No abstract available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No abstract available |
| 39443544 | Profiling of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma in a cross-sectional study. | No abstract available |
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