Protein detail
VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1)
Entry name VIP1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1)
Protein Class
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
HISPPD2AIPS1KIAA0377VIP1
Gene Description
Diphosphoinositol pentakisphosphate kinase 1
Chromosome
15
Position
43533462-43590208
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
- GO:0000828 inositol hexakisphosphate kinase activity
- GO:0000829 diphosphoinositol pentakisphosphate kinase activity
- GO:0000832 inositol hexakisphosphate 5-kinase activity
- GO:0005524 ATP binding
- GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity
- GO:0052723 inositol hexakisphosphate 1-kinase activity
Biological Process
KEGG
Reactome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing | 16 | 27863537329441933994064137786918381689064074865834817906289865852789410430646616309501853391918339948040383215353955813432089743 |
Sequence, Structure & Domains
Sequences
Length
1,433
Mass
159,521
Sequence
MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVKHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDPQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTRSTSLLNSMTIIQNPVKVCDQVFALIENLTHQIRERMQDPRSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLCYLRYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALDYLSAISELNYMTQIVIMLYEDNTQDPLSEERFHVELHFSPGVKGVEEEGSAPAGCGFRPASSENEEMKTNQGSMENLCPGKASDEPDRALQTSPQPPEGPGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLSRVCQRHTDAQAQASAALFDSMHSSQASDNPFSPPRTLHSPPLQLQQRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSQFGFSDQPSLNSHVAEEHQGLGLLQETPGSGAQELSIEGEQELFEPNQSPQVPPMETSQPYEEVSQPCQEVPDISQPCQDISEALSQPCQKVPDISQQCQENHDNGNHTCQEVPHISQPCQKSSQLCQKVSEEVCQLCLENSEEVSQPCQGVSVEVGKLVHKFHVGVGSLVQETLVEVGSPAEEIPEEVIQPYQEFSVEVGRLAQETSAINLLSQGIPEIDKPSQEFPEEIDLQAQEVPEEIN
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q6PFW1-1; Sequence=Displayed; Name=2; IsoId=Q6PFW1-2; Sequence=VSP_030618, VSP_030622; Name=3; IsoId=Q6PFW1-3; Sequence=VSP_030618, VSP_030621; Name=4; IsoId=Q6PFW1-4; Sequence=VSP_030615, VSP_030618, VSP_030621; Name=5; IsoId=Q6PFW1-5; Sequence=VSP_030616, VSP_030619, VSP_030623; Name=6; IsoId=Q6PFW1-6; Sequence=VSP_030617; Name=7; IsoId=Q6PFW1-7; Sequence=VSP_030618, VSP_030620, VSP_030624
Alternative Sequence
653; Missing (in isoform 4); 810..821; Missing (in isoform 5); 818..1433; Missing (in isoform 6); 818..821; Missing (in isoform 2, isoform 3, isoform 4 and isoform 7); 865..957; Missing (in isoform 5); 1020..1082; Missing (in isoform 7); 1062..1082; Missing (in isoform 3 and isoform 4); 1082; N -> NG (in isoform 2); 1107..1240; Missing (in isoform 5); 1167; Y -> LETRFCHVGQAGLELLTSSDLPASASQSAGITGVSHRTQPD (in isoform 7)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1005..1020; Polar residues; 1134..1143; Polar residues; 1168..1186; Low complexity; 1187..1199; Polar residues; 1236..1250; Polar residues
Domain (CC)
The C-terminal acid phosphatase-like domain binds PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.
Region
382..453; Polyphosphoinositide-binding domain; 915..1020; Disordered; 1134..1199; Disordered; 1235..1257; Disordered
Protein Families
- Histidine acid phosphatase family
- VIP1 subfamily
Sequence Similarities
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Clinical Relevance
Antibody