Protein detail

VIP1

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1)

Entry name VIP1	UniProt ID Q6PFW1	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein Class (3)

EnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000168781

Entrez Gene Symbol

PPIP5K1

Gene Synonym (4)

HISPPD2AIPS1KIAA0377VIP1

Gene Description

Diphosphoinositol pentakisphosphate kinase 1

Chromosome

Position

43533462-43590208

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (7)

Biological Process (3)

KEGG (3)

Reactome (2)

Mediation Categories

Metabolism mediation

Relations & Evidence8

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HMGN1 MIF4GD PDXDC1 PPIP5K1	A9UHW6 P05114 Q6P996 Q6PFW1	0:0:0:0	Havugimana2012	Havugimana2012:C_215

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing	16	27863537 32944193 39940641 37786918 38168906 40748658 34817906 28986585 27894104 30646616 30950185 33919183 39948040 38321535 39558134 32089743

Sequence, Structure & Domains10

Sequences

Length

1,433

Mass

159,521

Sequence

MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVKHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDPQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTRSTSLLNSMTIIQNPVKVCDQVFALIENLTHQIRERMQDPRSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLCYLRYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALDYLSAISELNYMTQIVIMLYEDNTQDPLSEERFHVELHFSPGVKGVEEEGSAPAGCGFRPASSENEEMKTNQGSMENLCPGKASDEPDRALQTSPQPPEGPGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLSRVCQRHTDAQAQASAALFDSMHSSQASDNPFSPPRTLHSPPLQLQQRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSQFGFSDQPSLNSHVAEEHQGLGLLQETPGSGAQELSIEGEQELFEPNQSPQVPPMETSQPYEEVSQPCQEVPDISQPCQDISEALSQPCQKVPDISQQCQENHDNGNHTCQEVPHISQPCQKSSQLCQKVSEEVCQLCLENSEEVSQPCQGVSVEVGKLVHKFHVGVGSLVQETLVEVGSPAEEIPEEVIQPYQEFSVEVGRLAQETSAINLLSQGIPEIDKPSQEFPEEIDLQAQEVPEEIN

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q6PFW1-1; Sequence=Displayed; Name=2; IsoId=Q6PFW1-2; Sequence=VSP_030618, VSP_030622; Name=3; IsoId=Q6PFW1-3; Sequence=VSP_030618, VSP_030621; Name=4; IsoId=Q6PFW1-4; Sequence=VSP_030615, VSP_030618, VSP_030621; Name=5; IsoId=Q6PFW1-5; Sequence=VSP_030616, VSP_030619, VSP_030623; Name=6; IsoId=Q6PFW1-6; Sequence=VSP_030617; Name=7; IsoId=Q6PFW1-7; Sequence=VSP_030618, VSP_030620, VSP_030624

Alternative Sequence

653; Missing (in isoform 4); 810..821; Missing (in isoform 5); 818..1433; Missing (in isoform 6); 818..821; Missing (in isoform 2, isoform 3, isoform 4 and isoform 7); 865..957; Missing (in isoform 5); 1020..1082; Missing (in isoform 7); 1062..1082; Missing (in isoform 3 and isoform 4); 1082; N -> NG (in isoform 2); 1107..1240; Missing (in isoform 5); 1167; Y -> LETRFCHVGQAGLELLTSSDLPASASQSAGITGVSHRTQPD (in isoform 7)

Domain & Motif Annotations

Compositional Bias

1005..1020; Polar residues; 1134..1143; Polar residues; 1168..1186; Low complexity; 1187..1199; Polar residues; 1236..1250; Polar residues

Domain (CC)

The C-terminal acid phosphatase-like domain binds PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.

Region

382..453; Polyphosphoinositide-binding domain; 915..1020; Disordered; 1134..1199; Disordered; 1235..1257; Disordered

Protein Families (2)

Histidine acid phosphatase family
VIP1 subfamily

Sequence Similarities

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Clinical Relevance1

Antibody

HPA039380

Supporting Publications1

PMID	Title	Abstract
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available