Protein detail

FBX38

F-box only protein 38

Protein symbol FBX38	UniProt ID Q6PIJ6	EVMP score 0.50
Frequency 6	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

Basic Information

Protein Names

F-box only protein 38

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000145868

Entrez Gene Symbol

FBXO38

Gene Synonym

Fbx38FLJ13962MOKASP329

Gene Description

F-box protein 38

Chromosome

Position

148383935-148442836

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificNeutrophils

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Adhesion and uptake mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FBX38	Q6PIJ6	KLF7	O75840	Yes	Yes	No	HPRDLit-BM-17SIGNOR	Lit-BM-17:14729953 HPRD:14729953 SIGNOR:14729953

Protein Complex Composition

9 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
SCF E3 ubiquitin ligase complexFBXO38 variant	CUL1 FBXO38 RBX1 SKP1	P62877 P63208 Q13616 Q6PIJ6	1:1:1:1	ComplexPortal	PDB:1LDJintact:EBI-44452174	34445249 14755292 15520277 35813202
	ARB2A FBXO38 FGL1 LCMT2	O60294 Q08830 Q6PIJ6 Q8WUF8	0:0:0:0	hu.MAP
	ARB2A FBXO38 FGL1 PPIL2	Q08830 Q13356 Q6PIJ6 Q8WUF8	0:0:0:0	hu.MAP
	AARS2 ARB2A FBXO38 FGL1	Q08830 Q5JTZ9 Q6PIJ6 Q8WUF8	0:0:0:0	hu.MAP
	ARB2A FBXO38 FGL1 PTGR3	Q08830 Q6PIJ6 Q8N4Q0 Q8WUF8	0:0:0:0	hu.MAP
	ARB2A FBXO38 FGL1 LSG1	Q08830 Q6PIJ6 Q8WUF8 Q9H089	0:0:0:0	hu.MAP
	ARB2A FBXO38 FGL1 TSR3	Q08830 Q6PIJ6 Q8WUF8 Q9UJK0	0:0:0:0	hu.MAP
	ARB2A FBXO38 FGL1 PRR12	Q08830 Q6PIJ6 Q8WUF8 Q9ULL5	0:0:0:0	hu.MAP
	ARB2A FBXO38 FGL1 KLF13	Q08830 Q6PIJ6 Q8WUF8 Q9Y2Y9	0:0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	R SequencingMass spectrometry	5	40189497 40985879 30915084 36146834 38207106

Sequence, Structure & Domains

Sequences

Length

1,188

Mass

133,944

Sequence

MGPRKKSVKTCIMNNEIPEEMTADETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDASFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDDNNAQNNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDIVQEDGEVVAESGNNTPAHSQAIIPVDVDEEQAGPSGLQRVVKPTSITVHDSESDDEEDSLELQEVWIPKNGTRRYSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHNTASQSPDFVRTVNSGGSSEPSPTEVDVSRQCACSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVLLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PIJ6-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=Q6PIJ6-2; Sequence=VSP_011449; Name=3; IsoId=Q6PIJ6-3; Sequence=VSP_011448, VSP_011449

Alternative Sequence

640..809; Missing (in isoform 3); 810..884; Missing (in isoform 2 and isoform 3)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

491..509; Low complexity; 621..630; Basic and acidic residues; 685..699; Basic and acidic residues; 703..740; Polar residues; 787..798; Basic and acidic residues; 849..861; Polar residues; 889..900; Basic residues

Motif

194..201; Nuclear export signal 1; 307..316; Nuclear export signal 2; 451..460; Nuclear export signal 3; 896..899; Nuclear localization signal

Domain (FT)

30..75; F-box

Region

59..119; Interaction with KLF7; 487..526; Disordered; 620..666; Disordered; 685..766; Disordered; 787..909; Disordered

Clinical Relevance

Disease Involvement

Disease variantNeurodegenerationNeuropathy

Antibody

HPA034821