Protein detail
FBX38
F-box only protein 38
Entry name FBX38 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 6 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
F-box only protein 38
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
Fbx38FLJ13962MOKASP329
Gene Description
F-box protein 38
Chromosome
5
Position
148383935-148442836
Supporting publications (n)
6
EVMP confidence score
0.50
Fluorescence & Localization1
Cell SpecificNeutrophils
Function & Pathway5
Protein Function (3)
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationImmune mediation
Relations & Evidence16
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FBX38 | Q6PIJ6 | KLF7 | O75840 | Yes | Yes | No | HPRDLit-BM-17SIGNOR | Lit-BM-17:14729953HPRD:14729953SIGNOR:14729953 |
Protein Complex Composition (9)
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SCF E3 ubiquitin ligase complexFBXO38 variant | CUL1FBXO38RBX1SKP1 | P62877P63208Q13616Q6PIJ6 | 1:1:1:1 | ComplexPortal | PDB:1LDJintact:EBI-44452174 | 34445249147552921552027735813202 |
| ARB2AFBXO38FGL1LCMT2 | O60294Q08830Q6PIJ6Q8WUF8 | 0:0:0:0 | hu.MAP | |||
| ARB2AFBXO38FGL1PPIL2 | Q08830Q13356Q6PIJ6Q8WUF8 | 0:0:0:0 | hu.MAP | |||
| AARS2ARB2AFBXO38FGL1 | Q08830Q5JTZ9Q6PIJ6Q8WUF8 | 0:0:0:0 | hu.MAP | |||
| ARB2AFBXO38FGL1PTGR3 | Q08830Q6PIJ6Q8N4Q0Q8WUF8 | 0:0:0:0 | hu.MAP | |||
| ARB2AFBXO38FGL1LSG1 | Q08830Q6PIJ6Q8WUF8Q9H089 | 0:0:0:0 | hu.MAP | |||
| ARB2AFBXO38FGL1TSR3 | Q08830Q6PIJ6Q8WUF8Q9UJK0 | 0:0:0:0 | hu.MAP | |||
| ARB2AFBXO38FGL1PRR12 | Q08830Q6PIJ6Q8WUF8Q9ULL5 | 0:0:0:0 | hu.MAP | |||
| ARB2AFBXO38FGL1KLF13 | Q08830Q6PIJ6Q8WUF8Q9Y2Y9 | 0:0:0:0 | hu.MAP |
Sequence, Structure & Domains9
Sequences
Length
1,188
Mass
133,944
Sequence
MGPRKKSVKTCIMNNEIPEEMTADETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDASFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDDNNAQNNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDIVQEDGEVVAESGNNTPAHSQAIIPVDVDEEQAGPSGLQRVVKPTSITVHDSESDDEEDSLELQEVWIPKNGTRRYSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHNTASQSPDFVRTVNSGGSSEPSPTEVDVSRQCACSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVLLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PIJ6-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=Q6PIJ6-2; Sequence=VSP_011449; Name=3; IsoId=Q6PIJ6-3; Sequence=VSP_011448, VSP_011449
Alternative Sequence
640..809; Missing (in isoform 3); 810..884; Missing (in isoform 2 and isoform 3)
Domain & Motif Annotations
Compositional Bias
491..509; Low complexity; 621..630; Basic and acidic residues; 685..699; Basic and acidic residues; 703..740; Polar residues; 787..798; Basic and acidic residues; 849..861; Polar residues; 889..900; Basic residues
Motif
194..201; Nuclear export signal 1; 307..316; Nuclear export signal 2; 451..460; Nuclear export signal 3; 896..899; Nuclear localization signal
Domain (FT)
30..75; F-box
Region
59..119; Interaction with KLF7; 487..526; Disordered; 620..666; Disordered; 685..766; Disordered; 787..909; Disordered
Clinical Relevance2
Disease Involvement (3)
Disease variantNeurodegenerationNeuropathy
Antibody
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |