Protein detail

FBX38

F-box only protein 38

Entry name
FBX38
UniProt ID
Q6PIJ6
EVMP confidence score
0.63
Supporting publications (n)
6
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteins
Basic Information
Protein Names
F-box only protein 38
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • Disease related genes
  • Predicted intracellular proteins
Ensembl
ENSG00000145868
Entrez Gene Symbol
FBXO38
Gene Synonym (4)
Fbx38FLJ13962MOKASP329
Gene Description
F-box protein 38
Chromosome
5
Position
148383935-148442836
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization
Cell SpecificNeutrophils
Function & Pathway
Protein Function (3)
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • Disease related genes
  • Predicted intracellular proteins
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationImmune mediation
Relations & Evidence16

Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
FBX38Q6PIJ6KLF7O75840YesYesHPRDLit-BM-17SIGNORLit-BM-17:14729953HPRD:14729953SIGNOR:14729953

Protein Complex Composition (9)

9 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
SCF E3 ubiquitin ligase complexFBXO38 variantCUL1FBXO38RBX1SKP1P62877P63208Q13616Q6PIJ61:1:1:1ComplexPortalPDB:1LDJintact:EBI-4445217434445249147552921552027735813202
ARB2AFBXO38FGL1LCMT2O60294Q08830Q6PIJ6Q8WUF80:0:0:0hu.MAP
ARB2AFBXO38FGL1PPIL2Q08830Q13356Q6PIJ6Q8WUF80:0:0:0hu.MAP
AARS2ARB2AFBXO38FGL1Q08830Q5JTZ9Q6PIJ6Q8WUF80:0:0:0hu.MAP
ARB2AFBXO38FGL1PTGR3Q08830Q6PIJ6Q8N4Q0Q8WUF80:0:0:0hu.MAP
ARB2AFBXO38FGL1LSG1Q08830Q6PIJ6Q8WUF8Q9H0890:0:0:0hu.MAP
ARB2AFBXO38FGL1TSR3Q08830Q6PIJ6Q8WUF8Q9UJK00:0:0:0hu.MAP
ARB2AFBXO38FGL1PRR12Q08830Q6PIJ6Q8WUF8Q9ULL50:0:0:0hu.MAP
ARB2AFBXO38FGL1KLF13Q08830Q6PIJ6Q8WUF8Q9Y2Y90:0:0:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyR SequencingMass spectrometry54018949740985879309150843614683438207106
Sequence, Structure & Domains

Sequences

Length
1,188
Mass
133,944
Sequence
MGPRKKSVKTCIMNNEIPEEMTADETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDASFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDDNNAQNNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDIVQEDGEVVAESGNNTPAHSQAIIPVDVDEEQAGPSGLQRVVKPTSITVHDSESDDEEDSLELQEVWIPKNGTRRYSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHNTASQSPDFVRTVNSGGSSEPSPTEVDVSRQCACSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVLLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PIJ6-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=Q6PIJ6-2; Sequence=VSP_011449; Name=3; IsoId=Q6PIJ6-3; Sequence=VSP_011448, VSP_011449
Alternative Sequence
640..809; Missing (in isoform 3); 810..884; Missing (in isoform 2 and isoform 3)

Domain & Motif Annotations

Compositional Bias
491..509; Low complexity; 621..630; Basic and acidic residues; 685..699; Basic and acidic residues; 703..740; Polar residues; 787..798; Basic and acidic residues; 849..861; Polar residues; 889..900; Basic residues
Motif
194..201; Nuclear export signal 1; 307..316; Nuclear export signal 2; 451..460; Nuclear export signal 3; 896..899; Nuclear localization signal
Domain (FT)
30..75; F-box
Region
59..119; Interaction with KLF7; 487..526; Disordered; 620..666; Disordered; 685..766; Disordered; 787..909; Disordered
Clinical Relevance
Disease Involvement (3)
Disease variantNeurodegenerationNeuropathy
Antibody
HPA034821
Supporting Publications6
PMIDTitleRelated sentences
28986585Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.No related sentences available
32089743Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.No related sentences available
33709510Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.No related sentences available
34817906Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.No related sentences available
37786918Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.No related sentences available
38321535Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.No related sentences available