Protein detail
KCNV1
Potassium voltage-gated channel subfamily V member 1 (Neuronal potassium channel alpha subunit HNKA) (Voltage-gated potassium channel subunit Kv8.1)
Protein symbol KCNV1 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 6 | Protein classification |
Basic Information
Protein Names
Potassium voltage-gated channel subfamily V member 1 (Neuronal potassium channel alpha subunit HNKA) (Voltage-gated potassium channel subunit Kv8.1)
Protein Function
Voltage-gated ion channels:Voltage-Gated Potassium Channels
Transmembrane
211..231; Helical; Name=Segment S1; 239..259; Helical; Name=Segment S2; 277..297; Helical; Name=Segment S3; 310..331; Helical; Voltage-sensor; Name=Segment S4; 346..366; Helical; Name=Segment S5; 407..427; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function
Voltage-gated ion channels:Voltage-Gated Potassium Channels
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| voltage_gated_potassium | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| potassium | ion_channel | Almen2009 | No | Yes | No | No | No |
| voltage_gated | ion_channel | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingFlow cytometry | 1 | 38321535 |
Sequence, Structure & Domains
Sequences
Length
500
Mass
56,304
Sequence
MPSSGRALLDSPLDSGSLTSLDSSVFCSEGEGEPLALGDCFTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMALMSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEMLRLKGRERASTRSSGGDDFWF
3D Structural Models
Domain & Motif Annotations
Compositional Bias
168..181; Basic and acidic residues
Motif
392..397; Selectivity filter
Domain (CC)
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Region
168..189; Disordered
Protein Families
- Potassium channel family
- V (TC 1.A.1.2) subfamily
- Kv8.1/KCNV1 sub-subfamily
Sequence Similarities
Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.