Protein detail

TMED8

Protein TMED8

Entry name TMED8	UniProt ID Q6PL24	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein TMED8

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000100580

Entrez Gene Symbol

TMED8

Gene Synonym

FAM15B

Gene Description

Transmembrane p24 trafficking protein family member 8

Chromosome

Position

77335029-77377094

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell Specificmonocytes

Function & Pathway4

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence4

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster328	ACBD3 BLZF1 TMED8	Q6PL24 Q9H2G9 Q9H3P7	1:1:1	Compleat	Compleat:HC3208	22036573

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	6	32848136 34684727 36263165 37040507 39136603 39229506

Sequence, Structure & Domains6

Sequences

Length

325

Mass

35,740

Sequence

MSDLQAAEGPGSWSPTARPGSAGGVGDCQGVEGSQAAASENEDLENKDTSLLASATDPEPCSSPHRPQMVSPVSKDATEDLRKATGPLEAQALVKQDLLPADQAQVLNEMAKYQVPQRSGDIVMIQSEHTGAIDVLSADLESADLLGDHRKVSPPLMAPPCIWTFAKVKEFKSKLGKEKNSRLVVKRGEVVTIRVPTHPEGKRVCWEFATDDYDIGFGVYFDWTPVTSTDITVQVSDSSDDEDEEEEEEEEIEEPVPAGDVERGSRSSLRGRYGEVMPVYRRDSHRDVQAGSHDYPGEGIYLLKFDNSYSLLRNKTLYFHIYYTS

Domain & Motif Annotations

Compositional Bias

238..254; Acidic residues

Domain (FT)

159..323; GOLD

Region

1..78; Disordered; 232..267; Disordered

Clinical Relevance4

Antibody

HPA001205

Interaction Protein

ENSG00000106803

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications3

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available