Protein detail

AGRD1

Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-terminal fragment (ADGRD1 C-terminal fragment)]

Entry name
AGRD1
UniProt ID
Q6QNK2
EVMP confidence score
0.50
Supporting publications (n)
3
Transmembrane count
7
Protein classification
G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-terminal fragment (ADGRD1 C-terminal fragment)]
Protein Class (3)
G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
  • G-protein coupled receptors:Family 2 (B) receptors
  • Predicted intracellular proteins
  • G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
568..590; Helical; Name=1; 602..623; Helical; Name=2; 633..655; Helical; Name=3; 674..695; Helical; Name=4; 711..732; Helical; Name=5; 758..780; Helical; Name=6; 784..810; Helical; Name=7
Transmembrane Count
7
Ensembl
ENSG00000111452
Entrez Gene Symbol
ADGRD1
Gene Synonym (3)
DKFZp434B1272GPR133PGR25
Gene Description
Adhesion G protein-coupled receptor D1
Chromosome
12
Position
130953907-131141469
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway5
Protein Function (3)
  • G-protein coupled receptors:Family 2 (B) receptors
  • Predicted intracellular proteins
  • G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence44

Ligand-Receptor Signaling (43)

43 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorCellCellInteractionsNoYesNoYesNo
gpcrreceptorGPCRdbNoYesNoYesNo
transmembranetransmembrane_predictedPhobiusNoNoNoYesNo
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Mass spectrometry0
Sequence, Structure & Domains15

Sequences

Length
874
Mass
96,530
Sequence
MEKLLRLCCWYSWLLLFYYNFQVRGVYSRSQDHPGFQVLASASHYWPLENVDGIHELQDTTGDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGPEGVTFSFFWKTQGEQSRPIPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEASFSPPGPYWTHVLFTWKSKEGLKVYVNGTLSTSDPSGKVSRDYGESNVNLVIGSEQDQAKCYENGAFDEFIIWERALTPDEIAMYFTAAIGKHALLSSTLPSLFMTSTASPVMPTDAYHPIITNLTEERKTFQSPGVILSYLQNVSLSLPSKSLSEQTALNLTKTFLKAVGEILLLPGWIALSEDSAVVLSLIDTIDTVMGHVSSNLHGSTPQVTVEGSSAMAEFSVAKILPKTVNSSHYRFPAHGQSFIQIPHEAFHRHAWSTVVGLLYHSMHYYLNNIWPAHTKIAEAMHHQDCLLFATSHLISLEVSPPPTLSQNLSGSPLITVHLKHRLTRKQHSEATNSSNRVFVYCAFLDFSSGEGVWSNHGCALTRGNLTYSVCRCTHLTNFAILMQVVPLELARGHQVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTSNAKPFHSDLMNGTRPGMASTKLSPWDKSSHSAHRVDLSAV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6QNK2-1; Sequence=Displayed; Name=2; IsoId=Q6QNK2-2; Sequence=VSP_012788, VSP_012789; Name=3; IsoId=Q6QNK2-3; Sequence=VSP_012787, VSP_012790; Name=4; IsoId=Q6QNK2-4; Sequence=VSP_053678
Alternative Sequence
1..481; Missing (in isoform 3); 1..314; Missing (in isoform 2); 62; G -> GASRTHKLTVLPSRNATFVYSNDSAYSNLSATV (in isoform 4); 315..341; QTALNLTKTFLKAVGEILLLPGWIALS -> MEKGTELLVSPSQSGPGGDQPLLVKHR (in isoform 2); 482..491; LITVHLKHRL -> MHRVCFLSFQ (in isoform 3)

3D Structural Models

Turn
564..567; 665..668; 679..681; 721..725
Helix
547..551; 569..591; 600..614; 617..623; 630..661; 672..678; 682..692; 714..720; 726..743; 746..749; 754..768; 771..773; 774..777; 788..806; 813..826
Beta Strand
559..563; 593..597; 627..629; 695..699; 701..706; 708..712; 780..782; 807..809
3D Structure
Electron microscopy (8)

Domain & Motif Annotations

Compositional Bias
861..874; Basic and acidic residues
Domain (CC)
The Stachel sequence (also named stalk) in the C-terminal part of the extracellular domain (ECD) functions as a tethered agonist (PubMed:25533341). In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation (PubMed:35418678, PubMed:35418679). On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling (PubMed:35418678, PubMed:35418679).; DOMAIN: The N-terminal domain and autocatalytic activity of ADGRD1 at the GPCR proteolysis site (GPS) are not required for G-protein coupling activity.
Domain (FT)
79..276; Pentraxin (PTX); 371..557; GAIN-B
Region
510..557; GPS; 546..554; Stachel; 854..874; Disordered
Protein Families (2)
  • G-protein coupled receptor 2 family
  • Adhesion G-protein coupled receptor (ADGR) subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Clinical Relevance1
Antibody (2)
HPA042395HPA076279
Supporting Publications3
PMIDTitleAbstract
31805958Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.No abstract available
32854315Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
36146834Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.No abstract available