Protein detail
CRTC1
CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)
Entry name CRTC1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)
Protein Class (4)
Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (4)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Head and neck cancers
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
FLJ14027KIAA0616MECT1TORC1
Gene Description
CREB regulated transcription coactivator 1
Chromosome
19
Position
18683678-18782333
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificCardiomyocytesSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function (4)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Head and neck cancers
- Disease related genes
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Reactome (8)
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9909396 circadian clock
- R-hsa-9931509 expression of bmal arntl clock and npas2
- R-hsa-9707616 heme signaling
- R-hsa-1592230 mitochondrial biogenesis
- R-hsa-1852241 organelle biogenesis and maintenance
- R-hsa-9931510 phosphorylated bmal1 clock arntl clock activates expression of core clock genes
- R-hsa-2151201 transcriptional activation of mitochondrial biogenesis
Mediation Categories
Other mediation
Relations & Evidence18
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CRTC1 | SIK1 | P57059 | S | 151 | phosphorylation | dbPTM | dbPTM:18669648dbPTM:16817901dbPTM:17525332 |
| CRTC1 | SIK1 | P57059 | S | 167 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:16817901SIGNOR:16817901 |
| CRTC1 | SIK2 | Q9H0K1 | S | 151 | phosphorylation | dbPTM | dbPTM:18669648dbPTM:16817901dbPTM:17525332 |
| CRTC1 | STK11 | Q15831 | S | 151 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (6)
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AAPK1 | Q13131 | CRTC1 | Q6UUV9 | Yes | Yes | SIGNOR | SIGNOR:21331044 | |
| COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478 | CRTC1 | Q6UUV9 | Yes | Yes | SIGNOR | SIGNOR:21331044 | ||
| SIR1 | Q96EB6 | CRTC1 | Q6UUV9 | Yes | Yes | SIGNOR | SIGNOR:22179316 | |
| M3K1 | Q13233 | CRTC1 | Q6UUV9 | Yes | Yes | WangSIGNOR | SIGNOR:18784253 | |
| SIK1 | P57059 | CRTC1 | Q6UUV9 | Yes | Yes | Yes | iPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperWang | ProtMapper:16817901dbPTM:17525332dbPTM:16817901dbPTM:18669648SIGNOR:16817901 |
| STK11 | Q15831 | CRTC1 | Q6UUV9 | Yes | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:31693893PhosphoSite:20010869 |
Protein Complex Composition (2)
2 records.
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
634
Mass
67,300
Sequence
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKRVLLLTVPGMEETTSEADKNLSKQAWDTKKTGSRPKSCEVPGINIFPSADQENTTALIPATHNTGGSLPDLTNIHFPSPLPTPLDPEEPTFPALSSSSSTGNLAANLTHLGIGGAGQGMSTPGSSPQHRPAGVSPLSLSTEARRQQASPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPASQQPPPPPPPQAPVRLPPGGPLLPSASLTRGPQPPPLAVTVPSSLPQSPPENPGQPSMGIDIASAPALQQYRTSAGSPANQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMAARQANALSHQLEQFNMMENAISSSSLYSPGSTLNYSQAAMMGLTGSHGSLPDSQQLGYASHSGIPNIILTVTGESPPSLSKELTSSLAGVGDVSFDSDSQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6UUV9-1; Sequence=Displayed; Name=2; IsoId=Q6UUV9-2; Sequence=VSP_051749; Name=3; IsoId=Q6UUV9-3; Sequence=VSP_051750, VSP_051751
Alternative Sequence
81; Q -> QPSGFLGEALAAAPVSL (in isoform 2); 475..503; Missing (in isoform 3); 580..634; SLAGVGDVSFDSDSQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL -> HRGHLPDGPPVSGHAGTLPLSRPDGASPARGRPCSVPRQRPSL (in isoform 3)
3D Structural Models
Helix
152..155
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
151..174; Polar residues; 194..208; Basic and acidic residues; 271..283; Polar residues; 296..305; Polar residues; 314..331; Polar residues; 362..397; Pro residues; 446..479; Polar residues
Motif
242..258; Nuclear export signal
Region
110..174; Disordered; 191..221; Disordered; 258..331; Disordered; 357..479; Disordered
Protein Families
TORC family
Sequence Similarities
Belongs to the TORC family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Interaction Protein (7)
ENSG00000108953ENSG00000118260ENSG00000128245ENSG00000134308ENSG00000164924ENSG00000166913ENSG00000170027
Interaction Count
7
Interaction Dataset (3)
intact_biogrid_opencellintact_biogridbiogrid_opencell
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 36114323 | Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment. | No related sentences available |
| 39363010 | Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons. | No related sentences available |
| 40222457 | Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement. | No related sentences available |
| 40595564 | Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome. | No related sentences available |