Protein detail

CRTC1

CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)

Entry name CRTC1	UniProt ID Q6UUV9	EVMP confidence score 0.38
Supporting publications (n) 4	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)

Protein Class (4)

Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (4)

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Head and neck cancers
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000105662

Entrez Gene Symbol

CRTC1

Gene Synonym (4)

FLJ14027KIAA0616MECT1TORC1

Gene Description

CREB regulated transcription coactivator 1

Chromosome

Position

18683678-18782333

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization6

Tissue Specificlymphoid tissueCell SpecificCardiomyocytesSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cells

Function & Pathway7

Protein Function (4)

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Head and neck cancers
Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

KEGG

hsa05166 Human T-cell leukemia virus 1 infection

Reactome (8)

Mediation Categories

Other mediation

Relations & Evidence18

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CRTC1	SIK1	P57059	S	151	phosphorylation	dbPTM	dbPTM:18669648 dbPTM:16817901 dbPTM:17525332
CRTC1	SIK1	P57059	S	167	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:16817901 SIGNOR:16817901
CRTC1	SIK2	Q9H0K1	S	151	phosphorylation	dbPTM	dbPTM:18669648 dbPTM:16817901 dbPTM:17525332
CRTC1	STK11	Q15831	S	151	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
AAPK1	Q13131	CRTC1	Q6UUV9	Yes	No	Yes	SIGNOR	SIGNOR:21331044
	COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478	CRTC1	Q6UUV9	Yes	No	Yes	SIGNOR	SIGNOR:21331044
SIR1	Q96EB6	CRTC1	Q6UUV9	Yes	Yes	No	SIGNOR	SIGNOR:22179316
M3K1	Q13233	CRTC1	Q6UUV9	Yes	Yes	No	WangSIGNOR	SIGNOR:18784253
SIK1	P57059	CRTC1	Q6UUV9	Yes	Yes	Yes	iPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperWang	ProtMapper:16817901 dbPTM:17525332 dbPTM:16817901 dbPTM:18669648 SIGNOR:16817901
STK11	Q15831	CRTC1	Q6UUV9	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:31693893 PhosphoSite:20010869

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CRTC1 HOXB6 NAGK RAI1 RBM6 SCAF8 TAF15 TCF20 TTC23 ZBTB43 ZIC2	O43298 O95409 P17509 P78332 Q5W5X9 Q6UUV9 Q7Z5J4 Q92804 Q9UGU0 Q9UJ70 Q9UPN6	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	CRTC1 YWHAZ	P63104 Q6UUV9	2:2	PDB	PDB:7d8pPDB:7d9vPDB:7d8h

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains12

Sequences

Length

634

Mass

67,300

Sequence

MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKRVLLLTVPGMEETTSEADKNLSKQAWDTKKTGSRPKSCEVPGINIFPSADQENTTALIPATHNTGGSLPDLTNIHFPSPLPTPLDPEEPTFPALSSSSSTGNLAANLTHLGIGGAGQGMSTPGSSPQHRPAGVSPLSLSTEARRQQASPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPASQQPPPPPPPQAPVRLPPGGPLLPSASLTRGPQPPPLAVTVPSSLPQSPPENPGQPSMGIDIASAPALQQYRTSAGSPANQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMAARQANALSHQLEQFNMMENAISSSSLYSPGSTLNYSQAAMMGLTGSHGSLPDSQQLGYASHSGIPNIILTVTGESPPSLSKELTSSLAGVGDVSFDSDSQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6UUV9-1; Sequence=Displayed; Name=2; IsoId=Q6UUV9-2; Sequence=VSP_051749; Name=3; IsoId=Q6UUV9-3; Sequence=VSP_051750, VSP_051751

Alternative Sequence

81; Q -> QPSGFLGEALAAAPVSL (in isoform 2); 475..503; Missing (in isoform 3); 580..634; SLAGVGDVSFDSDSQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL -> HRGHLPDGPPVSGHAGTLPLSRPDGASPARGRPCSVPRQRPSL (in isoform 3)

3D Structural Models

Helix

152..155

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

151..174; Polar residues; 194..208; Basic and acidic residues; 271..283; Polar residues; 296..305; Polar residues; 314..331; Polar residues; 362..397; Pro residues; 446..479; Polar residues

Motif

242..258; Nuclear export signal

Region

110..174; Disordered; 191..221; Disordered; 258..331; Disordered; 357..479; Disordered

Protein Families

TORC family

Sequence Similarities

Belongs to the TORC family.

Clinical Relevance6

Disease Involvement

Cancer-related genes

Drugs (4)

DACTOLISIB XL765 SAPANISERTIB GEDATOLISIB

Antibody (2)

HPA022035 HPA063619

Interaction Protein (7)

ENSG00000108953ENSG00000118260ENSG00000128245ENSG00000134308ENSG00000164924ENSG00000166913ENSG00000170027

Interaction Count

Interaction Dataset (3)

intact_biogrid_opencellintact_biogridbiogrid_opencell

Supporting Publications4

PMID	Title	Abstract
36114323	Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment.	No abstract available
39363010	Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons.	No abstract available
40222457	Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement.	No abstract available
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No abstract available