Protein detail
CLC2A
C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)
Entry name CLC2A | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)
Protein Class
Predicted membrane proteins
Transmembrane
28..48; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
INPE5792KACLPILARUNQ5792
Gene Description
C-type lectin domain family 2 member A
Chromosome
12
Position
9898673-9932370
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificCardiomyocytes
Function & Pathway
Cellular Component
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
- M209 Pid p38 gamma delta pathway
- M238 Pid thrombin par1 pathway
- M12 Pid rhoa pathway
Mediation Categories
Immune mediation
Relations & Evidence27
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | Yes | ||||
| receptor | receptor | OmniPath | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | ||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | |||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Flow cytometry | 1 | 39363010 |
Sequence, Structure & Domains
Sequences
Length
174
Mass
19,972
Sequence
MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWFEIIGNGSFAFLSADGVHSSRGFIDIKWICSKPKYFL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CLEC2A1; IsoId=Q6UVW9-1; Sequence=Displayed; Name=2; Synonyms=CLEC2A2; IsoId=Q6UVW9-2; Sequence=VSP_035643
Alternative Sequence
138..174; FEIIGNGSFAFLSADGVHSSRGFIDIKWICSKPKYFL -> PSNSKWSCNWSLRQWLLLLGPLR (in isoform 2)
3D Structural Models
Turn
88..90; 108..111
Helix
79..87; 99..107
Beta Strand
60..65; 68..72; 114..121; 129..131; 143..149; 154..157; 163..170
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
65..174; C-type lectin
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 34992371 | EMT-Related Markers in Serum Exosomes are Potential Diagnostic Biomarkers for Invasive Pituitary Adenomas. | Compared with that in the noninvasive group, the expression of N-cad in the exosomes of the invasive group was significantly increased, and the expression of E-cad and Epcam was reduced. E-cadherin, N-cadherin, Epcam, TGF-\xce\xb2, Smad3, and Smad7 were detected in the tissues and exosomes in 10 cases of invasive PAs and 10 cases of noninvasive PAs by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blotting, and immunohistochemical analysis. |