Protein detail

CLC2A

C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)

Entry name CLC2A	UniProt ID Q6UVW9	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)

Protein Class

Predicted membrane proteins

Transmembrane

28..48; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000188393

Entrez Gene Symbol

CLEC2A

Gene Synonym (4)

INPE5792KACLPILARUNQ5792

Gene Description

C-type lectin domain family 2 member A

Chromosome

Position

9898673-9932370

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificCardiomyocytes

Function & Pathway5

Cellular Component

GO:0005886 plasma membrane

Molecular Function (3)

Biological Process (3)

Canonical Pathways (3)

M209 Pid p38 gamma delta pathway
M238 Pid thrombin par1 pathway
M12 Pid rhoa pathway

Mediation Categories

Immune mediation

Relations & Evidence27

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CLEC2A KLRF2	D3W0D1 Q6UVW9	1:1	PDB	PDB:4iop

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Flow cytometry	1	39363010

Sequence, Structure & Domains10

Sequences

Length

174

Mass

19,972

Sequence

MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWFEIIGNGSFAFLSADGVHSSRGFIDIKWICSKPKYFL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CLEC2A1; IsoId=Q6UVW9-1; Sequence=Displayed; Name=2; Synonyms=CLEC2A2; IsoId=Q6UVW9-2; Sequence=VSP_035643

Alternative Sequence

138..174; FEIIGNGSFAFLSADGVHSSRGFIDIKWICSKPKYFL -> PSNSKWSCNWSLRQWLLLLGPLR (in isoform 2)

3D Structural Models

Turn

88..90; 108..111

Helix

79..87; 99..107

Beta Strand

60..65; 68..72; 114..121; 129..131; 143..149; 154..157; 163..170

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

65..174; C-type lectin

Clinical Relevance1

Antibody (2)

HPA048530 HPA072407

Supporting Publications1

PMID	Title	Abstract
34992371	EMT-Related Markers in Serum Exosomes are Potential Diagnostic Biomarkers for Invasive Pituitary Adenomas.	Compared with that in the noninvasive group, the expression of N-cad in the exosomes of the invasive group was significantly increased, and the expression of E-cad and Epcam was reduced. E-cadherin, N-cadherin, Epcam, TGF-β, Smad3, and Smad7 were detected in the tissues and exosomes in 10 cases of invasive PAs and 10 cases of noninvasive PAs by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blotting, and immunohistochemical analysis.