Protein detail

SE6L2

Seizure 6-like protein 2

Entry name SE6L2	UniProt ID Q6UXD5	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Seizure 6-like protein 2

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

845..865; Helical

Transmembrane Count

Ensembl

ENSG00000174938

Entrez Gene Symbol

SEZ6L2

Gene Synonym (2)

FLJ90517PSK-1

Gene Description

Seizure related 6 homolog like 2

Chromosome

Position

29871159-29899550

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Biological Process (3)

Canonical Pathways

M185 Pid alk1 pathway

Mediation Categories

Other mediation

Relations & Evidence25

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
other_receptor_family	receptor	HPMR	No	Yes	No	Yes	No
transferrin	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ECT2 KIF23 PLK1 PRC1 RACGAP1 SEZ6L2 SNW1	O43663 P53350 Q02241 Q13573 Q6UXD5 Q9H0H5 Q9H8V3	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4007

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	30	40189497 37926756 36064647 26098714 38113368 28680152 35119778 37322475 33304478 36497184 34064677 26826536 31382537 36686464 33592500 40985879 34473505 32560723 32916986 41307968 36146834 33309826 27821849 40840701 31805958 33893753 38607062 38207106 38716512 32854315

Sequence, Structure & Domains10

Sequences

Length

910

Mass

97,560

Sequence

MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6UXD5-1; Sequence=Displayed; Name=2; Synonyms=psk-3; IsoId=Q6UXD5-2; Sequence=VSP_033595; Name=3; Synonyms=psk-1; IsoId=Q6UXD5-3; Sequence=VSP_033595, VSP_033596; Name=4; Synonyms=psk-2; IsoId=Q6UXD5-4; Sequence=VSP_033595, VSP_033597; Name=5; IsoId=Q6UXD5-5; Sequence=VSP_044739, VSP_033596; Name=6; IsoId=Q6UXD5-6; Sequence=VSP_045702, VSP_045703

Alternative Sequence

27..70; Missing (in isoform 5); 72..141; Missing (in isoform 2, isoform 3 and isoform 4); 171..284; Missing (in isoform 6); 651..910; Missing (in isoform 4); 829; K -> KVAYEELLDNRKLE (in isoform 6); 830; V -> VAYEELLDNRKLEV (in isoform 3 and isoform 5)

Domain & Motif Annotations

Compositional Bias

123..145; Pro residues

Domain (FT)

173..286; CUB 1; 288..347; Sushi 1; 349..459; CUB 2; 462..525; Sushi 2; 527..638; CUB 3; 642..701; Sushi 3; 703..766; Sushi 4; 769..830; Sushi 5

Region

41..48; O-glycosylated at one site; 65..152; Disordered

Protein Families

SEZ6 family

Sequence Similarities

Belongs to the SEZ6 family.

Clinical Relevance1

Antibody

HPA064471

Supporting Publications1

PMID	Title	Abstract
39996590	Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.	No abstract available