Protein detail

ELAP1

Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein)

Entry name
ELAP1
UniProt ID
Q6UXG2
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
1
Protein classification
Predicted intracellular proteinsPredicted membrane proteins
Basic Information
Protein Names
Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
911..931; Helical
Transmembrane Count
1
Ensembl
ENSG00000116299
Entrez Gene Symbol
ELAPOR1
Gene Synonym (3)
EIG121KIAA1324maba1
Gene Description
Endosome-lysosome associated apoptosis and autophagy regulator 1
Chromosome
1
Position
109113679-109206781
Supporting publications (n)
1
EVMP confidence score
0.53
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (2)
Biological Process (3)
Canonical Pathways (3)
  • M5880 Naba ecm affiliated
  • M5885 Naba matrisome associated
  • M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence20

Ligand-Receptor Signaling (19)

19 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularGO_IntercellYes
intracellularintracellularUniProt_locationYes
intracellularintracellularOmniPathYes
transmembranetransmembraneUniProt_locationYes
transmembranetransmembraneUniProt_topologyYes
transmembranetransmembraneUniProt_keywordYes
transmembrane_predictedtransmembraneOmniPathYes
transmembranetransmembraneTopDBYes
transmembranetransmembraneRamilowski_locationYes
transmembranetransmembraneOmniPathYes
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Polymer PrecipitationWestern blotting138731868
Sequence, Structure & Domains

Sequences

Length
1,013
Mass
111,382
Sequence
MAEPGHSHHLSARVRGRTERRIPRLWRLLLWAGTAFQVTQGTGPELHACKESEYHYEYTACDSTGSRWRVAVPHTPGLCTSLPDPIKGTECSFSCNAGEFLDMKDQSCKPCAEGRYSLGTGIRFDEWDELPHGFASLSANMELDDSAAESTGNCTSSKWVPRGDYIASNTDECTATLMYAVNLKQSGTVNFEYYYPDSSIIFEFFVQNDQCQPNADDSRWMKTTEKGWEFHSVELNRGNNVLYWRTTAFSVWTKVPKPVLVRNIAITGVAYTSECFPCKPGTYADKQGSSFCKLCPANSYSNKGETSCHQCDPDKYSEKGSSSCNVRPACTDKDYFYTHTACDANGETQLMYKWAKPKICSEDLEGAVKLPASGVKTHCPPCNPGFFKTNNSTCQPCPYGSYSNGSDCTRCPAGTEPAVGFEYKWWNTLPTNMETTVLSGINFEYKGMTGWEVAGDHIYTAAGASDNDFMILTLVVPGFRPPQSVMADTENKEVARITFVFETLCSVNCELYFMVGVNSRTNTPVETWKGSKGKQSYTYIIEENTTTSFTWAFQRTTFHEASRKYTNDVAKIYSINVTNVMNGVASYCRPCALEASDVGSSCTSCPAGYYIDRDSGTCHSCPTNTILKAHQPYGVQACVPCGPGTKNNKIHSLCYNDCTFSRNTPTRTFNYNFSALANTVTLAGGPSFTSKGLKYFHHFTLSLCGNQGRKMSVCTDNVTDLRIPEGESGFSKSITAYVCQAVIIPPEVTGYKAGVSSQPVSLADRLIGVTTDMTLDGITSPAELFHLESLGIPDVIFFYRSNDVTQSCSSGRSTTIRVRCSPQKTVPGSLLLPGTCSDGTCDGCNFHFLWESAAACPLCSVADYHAIVSSCVAGIQKTTYVWREPKLCSGGISLPEQRVTICKTIDFWLKVGISAGTCTAILLTVLTCYFWKKNQKLEYKYSKLVMNATLKDCDLPAADSCAIMEGEDVEDDLIFTSKKSLFGKIKSFTSKRTPDGFDSVPLKTSSGGLDMDL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6UXG2-1; Sequence=Displayed; Name=2; IsoId=Q6UXG2-2; Sequence=VSP_025116; Name=3; IsoId=Q6UXG2-3; Sequence=VSP_025115; Name=4; IsoId=Q6UXG2-4; Sequence=VSP_025117
Alternative Sequence
261..347; Missing (in isoform 3); 992..1013; RTPDGFDSVPLKTSSGGLDMDL -> FKDS (in isoform 2); 992..1013; RTPDGFDSVPLKTSSGGLDMDL -> QPAPVTISLSEDS (in isoform 4)

Domain & Motif Annotations

Domain (FT)
656..858; MRH
Protein Families
ELAPOR family
Sequence Similarities
Belongs to the ELAPOR family.
Clinical Relevance
Antibody (2)
HPA029869HPA070749
Supporting Publications1
PMIDTitleRelated sentences
30865381Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114.No related sentences available